Pair Name	Biochanin A, SB590885
Phytochemical Name	Biochanin A
Anticancer drug Name	SB590885
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The results identify an effective combination therapy for the most aggressive form of HCC and provide the possibility of therapeutic improvement for patients with advanced HCC.

Pair Name	Mahanine, Cisplatin
Phytochemical Name	Mahanine
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our results revealed that mahanine may be a prospective agent to reduce the concentration of cisplatin in adjunct for the treatment of cancer and thereby decreasing its toxicity.

Pair Name	Paeonol, Epirubicin
Phytochemical Name	Paeonol
Anticancer drug Name	Epirubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings suggest that combination of Paeonol and Epirubicin is potentially applicable for breast cancer treatment.

Pair Name	Polydatin, 2-Deoxy-d-glucose
Phytochemical Name	Polydatin
Anticancer drug Name	2-Deoxy-d-glucose
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Our study demonstrates that PD synergised with 2-DG to enhance its anti-cancer efficacy by inhibiting the ROS/PI3K/AKT/HIF-1α/HK2 signalling axis, providing a potential anti-cancer strategy.

Pair Name	Umbelliferone, Cisplatin
Phytochemical Name	Umbelliferone
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Combination of 7-hydroxycoumarin in a platinum(IV) complex derived from cisplatin enhanced cytotoxicity with multiple mechanisms of action.

Pair Name	10-Gingerol, Paclitaxel
Phytochemical	10-Gingerol
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This data suggests that 10-G may be used as a new chemotherapeutic synergist in combination with paclitaxel to enhance anticancer activity. The potential value of ADRB2 as a target for improving chemotherapy sensitivity was also emphasized.

Pair Name	20(s)-ginsenoside Rh2, TNF-related apoptosis inducing ligand
Phytochemical	20(s)-ginsenoside Rh2
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our study indicates that Rh2 may act as a sensitizer in combination with TRAIL to increase the efficacy of its anti-tumor activity.

Pair Name	Allicin, Fluorouracil
Phytochemical	Allicin
Drug	Fluorouracil
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway

Pair Name	All-trans retinoic acid, Decitabine
Phytochemical	All-trans-retinoic acid
Drug	Decitabine
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results demonstrate that combining DAC and ATRA has potential for the clinical treatment of HR-MDS/AML and merits further exploration.

Pair Name	Aloin, Irinotecan
Phytochemical	Aloin
Drug	Irinotecan
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our findings suggests that CPT-11 and Aloin are potential combination treatment partners against colorectal cancer. MicroRNA-133b may serve as a co-therapeutic target with IGF1R against colorectal cancer, which might overcome the existing treatment limitations.

Pair Name	Alpha-Hederin, Paclitaxel
Phytochemical	Alpha-Hederin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our findings suggest that α-Hed can increase the killing effect of Tax on NSCLC cells by promoting ROS accumulation, and that combining α-Hed with classical Tax represents a novel strategy for treating NSCLC.

Pair Name	Anacardic Acid, Bortezomib
Phytochemical	Anacardic Acid
Drug	Bortezomib
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The results of the present study suggest that AA/Bor combination may be a potential therapeutic strategy for MM treatment.

Pair Name	Apigenin, TNF-related apoptosis inducing ligand
Phytochemical	Apigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Apigenin sensitizes cells to TRAIL-induced apoptosis by activating both intrinsic and extrinsic apoptotic pathway-related caspases. The augmented apoptotic effect by TRAIL/apigenin combination was accompanied by triggering mitochondria-dependent signaling pathway, as indicated by Bax/Bcl-2 ratio up-regulation

Pair Name	Apigenin, TNF-related apoptosis inducing ligand
Phytochemical	Apigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2D10.Z]	Thyroid cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Apigenin synergizes with TRAIL through regulation of Bcl2 family proteins in inducing cytotoxicity, and suppression of AKT potentiates synergistic cytotoxicity of apigenin with TRAIL in ATC cells

Pair Name	Artesunate, Sorafenib
Phytochemical	Artesunate
Drug	Sorafenib
Disease Info	[ICD-11: XH50P3]	Non‑hodgkin lymphoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑Hodgkin lymphoma cells through inhibition of the STAT3 pathway

Pair Name	Astragaloside IV, Carboplatin
Phytochemical	Astragaloside IV
Drug	Carboplatin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our results suggested that AgIV enhanced carboplatin sensitivity in prostate cancer cell lines by suppressing AKT/NF-κB signaling, thus suppressed epithelial-mesenchymal transition induced by carboplatin. Our findings provided a new mechanism for AgIV in overcoming drug resistance of platinum-based chemotherapy and suggested a potential combination therapy of AgIV and carboplatin in prostate cancer.

Pair Name	Atractylenolide I, Cabozantinib
Phytochemical	Atractylenolide I
Drug	Cabozantinib
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Silencing Hsp27 inhibits EMT. ATL-1 can inhibit the malignant evolution of prostate cancer cells by inhibiting Hsp27/eIF4E. ATL-1 also enhanced chemosensitization of cabozantinib in prostate cancer.

Pair Name	Bakuchiol, TNF-related apoptosis inducing ligand
Phytochemical	Bakuchiol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The collective results suggest that bakuchiol facilitates TRAIL-induced apoptosis in colon cancer cells through up-regulation of the TRAIL receptors; DR4 and DR5 via ROS/JNK pathway signals.

Pair Name	Berbamine, Arcyriaflavin A
Phytochemical	Berbamine
Drug	Arcyriaflavin A
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our findings suggest that a novel combination therapy involving berbamine and ArcA could effectively eradicate glioblastoma stem-like cells.

Pair Name	Berbamine, Cisplatin
Phytochemical	Berbamine
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings indicate that Ber might be a promising adjuvant for enhancing the cancer cell killing effect of chemotherapy via the inhibition of autophagy. In this process, Nox2 might be a significant mediator of Ber-induced aberrant lysosomal acidification.

Pair Name	Berbamine, Sorafenib
Phytochemical	Berbamine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings identify a new type of natural STAT3 inhibitor and provide a novel approach to the enhancement of SORA efficacy by blocking the activation of STAT3.

Pair Name	Berbamine, Sorafenib
Phytochemical	Berbamine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Targeting Na+/K+-ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma

Pair Name	Beta-Elemene, Cisplatin
Phytochemical	Beta-Elemene
Drug	Cisplatin
Disease Info	[ICD-11: 2C94]	Bladder cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The results of the present study suggested that β-ELE inhibited the proliferation of bladder cancer cells in vitro and enhanced cisplatin-induced mitochondria-dependent apoptosis via the ROS-AMPK signaling pathway. Combination therapy with β-ELE requires further investigation as a potential treatment of bladder cancer.

Pair Name	Beta-Elemene, Etoposide
Phytochemical	Beta-Elemene
Drug	Etoposide
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results suggest that the combination of β-elemene and VP-16 may be a promising therapeutic option for lung cancer.

Pair Name	Beta-Elemene, TNF-related apoptosis inducing ligand
Phytochemical	Beta-Elemene
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Our results suggest that β-elemene increases the sensitivity of gastric cancer cells to TRAIL partially by promoting the formation of DISC in lipid rafts.

Pair Name	Betulinic acid, Imatinib
Phytochemical	Betulinic acid
Drug	Imatinib
Disease Info	[ICD-11: 2B33.2]	Chronic myeloid leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our findings demonstrated that HDAC3 is an essential factor in BCR-ABL1 kinase-independent IM resistance, and that BA in combination with IM may be a novel treatment strategy for overcoming IM resistance in CML.

Pair Name	Bisdemethoxycucurmin, Icotinib
Phytochemical	Bisdemethoxycucurmin
Drug	Icotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our data indicate that BMDC has the potential to improve the treatment of primary EGFR-TKI resistant NISCLC that cannot be controlled with single-target agent, such as icotinib.

Pair Name	Caffeic acid, Paclitaxel
Phytochemical	Caffeic acid
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our results indicated that CA inhibited NSCLC H1299 cell growth by inducing apoptosis and CA and PTX combined produced a synergistic anti-cancer effect in H1299 cells.

Pair Name	Capsaicin, Sorafenib
Phytochemical	Capsaicin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	These data confirm that capsaicin and sorafenib combination treatment inhibits the growth, invasion and metastasis of HCC cells and induces autophagy in a synergistic manner, supporting its potential as a therapeutic option for HCC.

Pair Name	Carnosic acid, Tamoxifen
Phytochemical	Carnosic acid
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our study supplies a novel therapeutic strategy to induce apoptosis for suppressing breast cancer, which was relied on Caspase-3/TRAIL activation.

Pair Name	Casticin, Fluorouracil
Phytochemical	Casticin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	We may suggest that 5-FU combined with casticin treatment increased apoptotic cell death in WEHI-3 mouse leukemia cells that may undergo mitochondria and caspases signaling pathways in vitro.

Pair Name	Celastrol, TNF-related apoptosis inducing ligand
Phytochemical	Celastrol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The results of our study demonstrate that celastrol sensitizes glioma cells to TRAIL via the death receptor pathway and that DR5 plays an important role in the effects of this cotreatment. The results indicate that this cotreatment is a promising tumor-killing therapeutic strategy with high efficacy and low toxicity.

Pair Name	Cepharanthine, Epirubicin
Phytochemical	Cepharanthine
Drug	Epirubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis

Pair Name	Chlorogenic acid, Doxorubicin
Phytochemical	Chlorogenic acid
Drug	Doxorubicin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings firstly propose CGA as a promising chemosensitizer and cardioprotective agent in OS therapy, suggesting the p44/42 MAPK pathway as relevantly involved in CGA-mediated Doxo susceptibility.

Pair Name	Chrysin, Cisplatin
Phytochemical	Chrysin
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The combination of Chrysin and Cisplatin Induces Apoptosis in HepG2 through Down-regulation of cFLIP and Activity of Caspase.

Pair Name	Chrysin, Cisplatin
Phytochemical	Chrysin
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Our results suggest that combination of chrysin and cisplatin is a promising strategy for chemotherapy of human cancers that are resistant to cisplatin.

Pair Name	Cianidanol, Fluorouracil
Phytochemical	Cianidanol
Drug	Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	We suggest catechin as a candidate for the development of a novel adjuvant drug that reduces chemoresistance to 5FU by restricting LDHA.

Pair Name	Cordycepin, Cisplatin
Phytochemical	Cordycepin
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This study provides comprehensive evidence that cordycepin inhibits osteosarcoma cell growth and invasion and induces osteosarcoma cell apoptosis by activating AMPK and inhibiting the AKT/mTOR signaling pathway and enhances the sensitivity of osteosarcoma cells to cisplatin, suggesting that cordycepin is a promising treatment for osteosarcoma.

Pair Name	Crocin, Sorafenib
Phytochemical	Crocin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	CR potentiates the suppressive effects of SB on tumor growth and provides the opportunity to strengthen the therapeutic effects of SB in the treatment of HCC.

Pair Name	Cucurbitacin B, Doxorubicin
Phytochemical	Cucurbitacin B
Drug	Doxorubicin
Disease Info	[ICD-11: 2D10.Z]	Thyroid cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Synergistic cytotoxicity of doxorubicin with cucurbitacin B is mediated by B-cell chronic lymphocytic leukemia/lymphoma 2 family proteins, survivin, and reactive oxygen species and modulated by Janus kinase 2/signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2 in anaplastic thyroid carcinoma cells.

Pair Name	Curcumenol, Cisplatin
Phytochemical	Curcumenol
Drug	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Curcumenol can enhance cisplatin to inhibit cancer cell proliferation, migration, and invasion and promote tumor cell apoptosis. The combination of drugs may promote the apoptosis of cervical cancer cells through the YWHAG pathway.

Pair Name	Curcumin, Fenretinide
Phytochemical	Curcumin
Drug	Fenretinide
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our findings suggest that the 2 small molecules, when used in combination, can potentially be effective therapeutic agents for treating NSCLC, at least in part, by regulating endoplasmic reticulum (ER) chaperone protein GRP78.

Pair Name	Curcumin, Olaparib
Phytochemical	Curcumin
Drug	Olaparib
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	The present study reveals that Cur + Ola treatment increased oral cancer cell death not only through catalytic inhibition of PARP-1 but also predominantly through PARP-1 trapping and indirect inhibition of chromatin remodeling.

Pair Name	Curcumol, Cisplatin
Phytochemical	Curcumol
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings suggest that curcumol inhibits the polarization of M2-like macrophages and could be a promising combination strategy to synergize with CDDP in the osteosarcoma.

Pair Name	Daurinoline, Sorafenib
Phytochemical	Daurinoline
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our study provides insights into the molecular mechanisms underlying DS-induced inhibition of VM, which may facilitate the development of a novel clinical anti-HCC drug. Moreover, our findings suggest that the combination of DS and sorafenib constitutes a potential therapeutic strategy for HCC.

Pair Name	Decursin, Doxorubicin
Phytochemical	Decursin
Drug	Doxorubicin
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The combination treatment of decursin and doxorubicin can enhance apoptotic activity via mTOR and/or STAT3 signaling pathway in multiple myeloma cells.

Pair Name	Dehydrobruceine B, Cisplatin
Phytochemical	Dehydrobruceine B
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results generated a rationale for further investigation of DHB combined with CDDP as a potential therapeutic strategy in lung cancer.

Pair Name	Delta-Tocotrienol, Cisplatin
Phytochemical	Delta-Tocotrienol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	δ-Tocotrienol sensitizes and re-sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK-mediated apoptosis

Pair Name	Dihydroartemisinin, Doxorubicin
Phytochemical	Dihydroartemisinin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This study presented a new opportunity to enhance the effectiveness of future treatment regimens of breast cancer using DOX.

Pair Name	Dihydrotanshinone I, Cisplatin
Phytochemical	Dihydrotanshinone I
Drug	Cisplatin
Disease Info	[ICD-11: 2D10.Z]	Thyroid cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	The present study is the first to demonstrate that DHT exerts antitumor effects on ATC cells by reducing MAD2 expression levels. Moreover, a synergistic effect of DHT with cisplatin was shown. Further in vivo studies are required to assess this phytochemical compound as a potential adjuvant for the treatment of ATC.

Pair Name	Emodin, Doxorubicin
Phytochemical	Emodin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Emodin Interferes With AKT1-Mediated DNA Damage and Decreases Resistance of Breast Cancer Cells to Doxorubicin

Pair Name	Epigallocatechin gallate, Fluorouracil
Phytochemical	Epigallocatechin gallate
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU.

Pair Name	Epigallocatechin gallate, TNF-related apoptosis inducing ligand
Phytochemical	Epigallocatechin gallate
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis

Pair Name	Epigallocatechin gallate, TNF-related apoptosis inducing ligand
Phytochemical	Epigallocatechin gallate
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis

Pair Name	Epsilon-Viniferin, alpha-Viniferin
Phytochemical	Epsilon-Viniferin
Drug	alpha-Viniferin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	ε-viniferin and α-viniferin may prove to be new approaches and effective therapeutic agents for osteosarcoma and lung cancer treatment.

Pair Name	Eriocalyxin B, Gemcitabine
Phytochemical	Eriocalyxin B
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Gem and EriB (or Isodon extract) taken together in combination regulated PDK1/AKT1/caspase and JNK signaling and promoted apoptosis synergistically, which may contribute to the much increased anti-proliferative activity compared to either agent alone.

Pair Name	Eugenol, Cisplatin
Phytochemical	Eugenol
Drug	Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results provide strong preclinical justification for combining cisplatin with eugenol as therapeutic approach for triple-negative breast cancers through targeting the resistant ALDH-positive cells and inhibiting the NF-κB pathway.

Pair Name	Eurycomalactone, Cisplatin
Phytochemical	Eurycomalactone
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Activity
Result	This finding provides a rationale for the combined use of chemotherapy drugs with ECL to improve their efficacy in NSCLC treatment.

Pair Name	Evodiamine, Doxorubicin
Phytochemical	Evodiamine
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Activity
Result	Our results indicated that EVO enhanced the apoptotic action of DOX by inhibiting the Ras/MEK/ERK cascade and the expression of IAPs without inhibiting the expression and activity of P-glycoprotein (P-gp). Taken together, our data indicate that EVO, a natural product, may be useful applied alone or in combination with DOX for the treatment of resistant breast cancer.

Pair Name	Fangchinoline, Everolimus
Phytochemical	Fangchinoline
Drug	Everolimus
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Firstly link CHOP to Notch 3/c-MYC axis-dependent apoptosis and provide the Notch 3/c-MYC/CHOP activation as a promising strategy for mTOR-targeted combination therapy in lung cancer treatment.

Pair Name	Fisetin, Sorafenib
Phytochemical	Fisetin
Drug	Sorafenib
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	The combination of fisetin and sorafenib exerted better synergistic effects in vitro and in vivo than either agent used alone against human cervical cancer, and this synergism was based on apoptotic potential through a mitochondrial- and DR5-dependent caspase-8/caspase-3 signaling pathway

Pair Name	Fisetin, Sorafenib
Phytochemical	Fisetin
Drug	Sorafenib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Fisetin potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells.

Pair Name	Flavokawain B, Bortezomib
Phytochemical	Flavokawain B
Drug	Bortezomib
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		cleavage
Result	These findings provide a rationale for further investigating combination of FKB and Bortezomib for treatment of RB deficient, castration-resistant prostate cancer.

Pair Name	Forskolin, Paclitaxel
Phytochemical	Forskolin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our findings encourage the design of future studies aimed at further exploring the Forskolin employment in NSCLC treatment.

Pair Name	Furanodiene, Doxorubicin
Phytochemical	Furanodiene
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results indicate that furanodiene may be a promising and safety natural agent for cancer adjuvant therapy in the future.

Pair Name	Gambogic Acid, Chloroquine
Phytochemical	Gambogic Acid
Drug	Chloroquine
Disease Info	[ICD-11: 2C10.0]	Pancreatic ductal adenocarcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

Pair Name	Gambogic Acid, Doxorubicin
Phytochemical	Gambogic Acid
Drug	Doxorubicin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings indicate that GA sensitizes lung cancer cells to ADM in vitro and in vivo, providing a rationale for the combined use of GA and ADM in lung cancer chemotherapy.

Pair Name	Gambogic Acid, Fluorouracil
Phytochemical	Gambogic Acid
Drug	Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Our data showed that GA attenuated 5-FU-induced apoptosis by modulating metabolic enzymes of 5-FU and the antigastric cancer effect of two drugs combination was much stronger than that of GA or 5-FU alone.

Pair Name	Gambogic Acid, Gemcitabine
Phytochemical	Gambogic Acid
Drug	Gemcitabine
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results offer a rationale to evaluate the clinical translational possibility of GA as adjuvant therapy to overcome Gem resistance. This combination regimen can be a new therapeutic concept to eradicate this devastating disease.

Pair Name	Gambogic Acid, Gemcitabine
Phytochemical	Gambogic Acid
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	These results demonstrate that gambogic acid sensitizes pancreatic cancer cells to gemcitabine in vitro and in vivo by inhibiting the activation of the ERK/E2F1/RRM2 signaling pathway. The results also indicate that gambogic acid treatment combined with gemcitabine might be a promising chemotherapy strategy for pancreatic cancer.

Pair Name	Gambogic Acid, MG132
Phytochemical	Gambogic Acid
Drug	MG132
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The combination of natural product gambogic acid and the proteasome inhibitor MG132 or MG262 results in a synergistic inhibitory effect on growth of malignant cells and tumors in allograft animal models and there was no apparent systemic toxicity observed in the animals treated with the combination

Pair Name	Gambogic Acid, TNF-related apoptosis inducing ligand
Phytochemical	Gambogic Acid
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings may open a new window in the treatment of breast cancer using TRAIL in combination with GA.

Pair Name	Gamma-Tocotrienol, Capecitabine
Phytochemical	Gamma-Tocotrienol
Drug	Capecitabine
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Our results show that γ-tocotrienol can potentiate the effects of capecitabine through suppression of NF-κB-regulated markers of proliferation, invasion, angiogenesis, and metastasis.

Pair Name	Gamma-Tocotrienol, Docetaxel
Phytochemical	Gamma-Tocotrienol
Drug	Docetaxel
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings suggest that the combination treatment with these agents may provide enhanced therapeutic response in oral cancer patients, while avoiding the toxicity associated with high-dose β-tubulin stabilization monotherapy.

Pair Name	Garcinol, Cisplatin
Phytochemical	Garcinol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our data demonstrated that garcinol has the potential to be used as an anticancer agent and may synergize the effect of DDP. These actions are most likely through the regulation of the PI3K/AKT and NF-κB pathways.

Pair Name	Ginsenoside Rg3, Tamoxifen
Phytochemical	Ginsenoside Rg3
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This study highlights the contribution of Rg3 in enhancing the therapeutic efficacy of TAM in breast cancer, and suggests that targeting TAM-resistant PFKFB3 overexpression may represent a promising strategy to improve the response to combination therapy in breast cancer.

Pair Name	Glucosinalbate, Doxorubicin
Phytochemical	Glucosinalbate
Drug	Doxorubicin
Disease Info	[ICD-11: 2C90]	Ehrlich ascites carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The present study clearly suggested therapeutic benefit of I3C in combination with DOX by augmenting anticancer efficacy and diminishing toxicity to the host.

Pair Name	Gossypol, Fluorouracil
Phytochemical	Gossypol
Drug	Fluorouracil
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings suggest that gossypol-mediated down-regulation of TS, cyclin D1, and the mTOR/p70S6K1 signaling pathways enhances the anti-tumor effect of 5-FU. Ultimately, our data exposed a new action for gossypol as an enhancer of 5-FU-induced cell growth suppression.

Pair Name	Gossypol, Idarubicin
Phytochemical	Gossypol
Drug	Idarubicin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings suggest that combinatorial therapy with AT-101 and IDA selectively eliminates leukemia stem-like cells both in vitro and in vivo, representing a potent and alternative salvage therapy for the treatment of relapsed and refractory patients with AML.

Pair Name	Gynostemma Extract, Fluorouracil
Phytochemical	Gynostemma Extract
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation

Pair Name	Halofuginone, Cisplatin
Phytochemical	Halofuginone
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways

Pair Name	Hederagenin, Cisplatin
Phytochemical	Hederagenin
Drug	Cisplatin
Disease Info	Head and neck cancer
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Hederagenin effectively targets cisplatin-resistant HNC cells in vitro and in vivo. Consistent with its effects in other types of cancer, hederagenin markedly induces apoptosis in HNC cells by activating the mitochondria-driven intrinsic apoptotic pathway. We demonstrated that the apoptosis-inducing effects of hederagenin are mediated by the inhibition of the Nrf2-ARE antioxidant pathway.

Pair Name	Helichrysetin, Tumor necrosis factor-alpha
Phytochemical	Helichrysetin
Drug	Tumor necrosis factor-alpha
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Activity
Result	Helichrysetin and TNF‑α synergistically promoted apoptosis by inhibiting TAK1/IKK/NF‑κB and TAK1/EGFR signaling pathways in HeLa and T98G cells, indicating a potential therapeutic strategy for cancer.

Pair Name	Hispidin, Gemcitabine
Phytochemical	Hispidin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Hispidin might be a novel chemosensitizer for gemcitabine and a potential synergistic agent for increasing the therapeutic index of gemcitabine as a treatment for pancreatic cancer.

Pair Name	Homoharringtonine, ACC010
Phytochemical	Homoharringtonine
Drug	ACC010
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	ACC010 and HHT cooperatively downregulated MYC and inhibited FLT3 activation. Further, when HHT was added, ACC010-resistant cells demonstrated a good synergy. We also extended our study to the mouse BaF3 cell line with FLT3-inhibitor-resistant FLT3-ITD/tyrosine kinase domain mutations and AML cells without FLT3-ITD. Collectively, our results suggested that the combination treatment of ACC010 and HHT might be a promising strategy for AML patients, especially those carrying FLT3-ITD.

Pair Name	Homoharringtonine, Suberoylanilide hydroxamic acid (SAHA)
Phytochemical	Homoharringtonine
Drug	Suberoylanilide hydroxamic acid (SAHA)
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Activity
Result	The synergistic effect between HHT and SAHA was blocked partially using a specific anti‑TRAIL antibody. The combination therapy was also found to significantly inhibit the growth of leukemia xenografts in vivo with enhanced apoptosis. These results indicate that, by regulating the induction of TRAIL and activation of the TRAIL apoptotic pathway, it is possible to administer HHT at low concentrations in combination with SAHA as an effective therapeutic approach for the treatment of AML.

Pair Name	Hypericin, Gemcitabine
Phytochemical	Hypericin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	We demonstrated that Gem combined HY-PDT could inhibit the proliferation of Capan-2 cells and induce cell apoptosis. HY-PDT combined with Gem had a great potential on pancreatic cancer treatment clinically.

Pair Name	Icariin, Arsenic oxide (As2O3)
Phytochemical	Icariin
Drug	Arsenic oxide (As2O3)
Disease Info	[ICD-11: XH1A50]	Acute promyelocytic leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our results showed that Icariin, by increasing intracellular ROS, exhibited antitumor activity and potentiated the antitumor activity of ATO against APL. Therefore, combination treatment with Icariin and ATO might offer a novel therapeutic option for patients with APL, although further studies are needed.

Pair Name	Icariin, Fluorouracil
Phytochemical	Icariin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	We suggest that combination of icariin with 5-FU might offer a therapeutic benefit to the patients with CRC; however, further studies are required to ascertain this proposition.

Pair Name	Icariin, Gemcitabine
Phytochemical	Icariin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C94]	Bladder cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Icariin, by suppressing NF-κB activity, exerts antitumor activity, and potentiates the antitumor activity of gemcitabine in gallbladder cancer. Combined administration of gemcitabine and icariin may offer a better therapeutic option for the patients with gallbladder cancer.

Pair Name	Icaritin, TNF-related apoptosis inducing ligand
Phytochemical	Icaritin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These data suggest that icaritin sensitizes TRAIL-induced tumor cell apoptosis via suppression of NF-κB-dependent c-FLIP expression, providing in vitro evidence supporting the notion that icaritin is a potential sensitizer of TRAIL in anticancer therapy against human GBM.

Pair Name	Irigenin, TNF-related apoptosis inducing ligand
Phytochemical	Irigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our present study gave new insights into the effects of Iri on potentiating TRAIL-sensitivity, and suggested that Iri could be a potential candidate for sensitizer of TRAIL-resistant cancer cell treatment.

Pair Name	Isorhamnetin, Chloroquine
Phytochemical	Isorhamnetin
Drug	Chloroquine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our study highlights the critical role of ROS-mediating CaMKII/Drp1 signaling in the regulation of mitochondrial fission and apoptosis induced by combination of CQ/IH. These findings also suggest that IH could potentially be further developed as a novel chemotherapeutic agent. Furthermore, a combination of IH with classic autophagy/mitophagy inhibitor could represent a novel therapeutic strategy for the treatment of TNBC.

Pair Name	Kaempferol, Erlotinib
Phytochemical	Kaempferol
Drug	Erlotinib
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These data imply that KAE may be a valid therapeutic candidate to potentiate PC cell sensitivity to ERL via inhibiting PI3K/AKT and EGFR signaling.

Pair Name	Kurarinone, TNF-related apoptosis inducing ligand
Phytochemical	Kurarinone
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells

Pair Name	Leonurine, Cisplatin
Phytochemical	Leonurine
Drug	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Leonurine and cisplatin have synergistic antitumorigenic effects on cervical cancer. Combination with leonurine may serve as a novel strategy for enhancing cisplatin sensitivity via the inhibition of the expression of MRP1 and P-Gp.

Pair Name	Licochalcone B, TNF-related apoptosis inducing ligand
Phytochemical	Licochalcone B
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	LCB exhibits cytotoxic activity through modulation of the Akt/mTOR, ER stress and MAPK pathways in HCC cells and effectively enhances TRAIL sensitivity through the upregulation of DR5 expression in ERK- and JNK-dependent manner. Combination therapy with LCB and TRAIL may be an alternative treatment strategy for HCC.

Pair Name	Licochalcone B, TNF-related apoptosis inducing ligand
Phytochemical	Licochalcone B
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	LCB exhibits cytotoxic activity through modulation of the Akt/mTOR, ER stress and MAPK pathways in HCC cells and effectively enhances TRAIL sensitivity through the upregulation of DR5 expression in ERK- and JNK-dependent manner. Combination therapy with LCB and TRAIL may be an alternative treatment strategy for HCC.

Pair Name	Liquiritin, TNF-related apoptosis inducing ligand
Phytochemical	Liquiritin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Combining TRAIL and liquiritin exerts synergistic effects against human gastric cancer cells and xenograft in nude mice through potentiating apoptosis and ROS generation

Pair Name	Liriodenine, Valproic acid
Phytochemical	Liriodenine
Drug	Valproic acid
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Liriodenine enhances the apoptosis effect of valproic acid in human colon cancer cells through oxidative stress upregulation and Akt inhibition

Pair Name	Luteolin, Erlotinib
Phytochemical	Luteolin
Drug	Erlotinib
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings suggest that combining luteolin with erlotinib offers a potential treatment strategy for glioblastoma multiforme IV.

Pair Name	Luteolin, IL-24
Phytochemical	Luteolin
Drug	IL-24
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These data confirm that the synergistic mechanism of VV-IL-24 and luteolin elicits a stronger tumor growth inhibition than any single therapy. Thus, the combination of VV-IL-24 and luteolin could provide the basis for preclinical research in the treatment of liver cancer.

Pair Name	Luteolin, Oxaliplatin
Phytochemical	Luteolin
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Luteolin can induce p53-mediated apoptosis regardless of oxaliplatin treatment and may eliminate oxaliplatin-resistant p53-null colorectal cells

Pair Name	Luteolin, SMC3
Phytochemical	Luteolin
Drug	SMC3
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The results suggest that combination of SMC3 and luteolin is an effective approach for improving the anticancer value of SMC3, which has implications in cancer prevention and therapy.

Pair Name	Luteolin, Sorafenib
Phytochemical	Luteolin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Sorafenib and luteolin combination synergistically kills HCC cells through JNK-mediated apoptosis, and luteolin may be an ideal candidate for increasing the activity of sorafenib in HCC therapy.

Pair Name	Luteolin, TNF-related apoptosis inducing ligand
Phytochemical	Luteolin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Data from this study thus provide strong in vivo evidence supporting that luteolin is a potential sensitizer for TRAIL in anticancer therapy.

Pair Name	Lycopene, Doxorubicin
Phytochemical	Lycopene
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our results thus show the therapeutic benefit of red guava extracts as a potential cancer treatment for TNBC in combination with doxorubicin or targeted therapy.

Pair Name	Magnolin, B-RAF Inhibitors
Phytochemical	Magnolin
Drug	B-RAF Inhibitors
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Synergistic activity of magnolin combined with B-RAF inhibitor SB590885 in hepatocellular carcinoma cells via targeting PI3K-AKT/mTOR and ERK MAPK pathway

Pair Name	Morin Hydrate, Cisplatin
Phytochemical	Morin Hydrate
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Our findings indicate that CP-Mh in combination served as a prominent regulator of autophagy and significant inducer of apoptosis that maintains a homeostatic balance towards HepG2 cells and the subcutaneous tumor model.

Pair Name	Morin, Auranofin
Phytochemical	Morin
Drug	Auranofin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This study provides evidence that morin can enhance the anticancer activity of AF in Hep3B human hepatocellular carcinoma cells, indicating that its combination could be an alternative treatment strategy for the hepatocellular carcinoma.

Pair Name	Morusin, MAPK pathway inhibitors
Phytochemical	Morusin
Drug	MAPK pathway inhibitors
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our results suggested that the combination of morusin and MAPK pathway inhibitors may be a more effective treatment strategy for BRAF-mutant melanoma than MAPK pathway inhibitors alone.

Pair Name	Naringenin, ABT-737
Phytochemical	Naringenin
Drug	ABT-737
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The combination of these drugs was found to further increase the cleavage of caspase-3 and poly ADP-ribose polymerase. Naringenin and ABT-737 also decreased Akt activation and increased p53 expression, suggesting the involvement of these pathways in the inhibition of gastric cell growth.

Pair Name	Naringenin, AMG-951
Phytochemical	Naringenin
Drug	AMG-951
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The present study provides a novel therapeutic strategy for glioma by potentiating APO2L-induced apoptosis via the combination with NG in glioma tumor cells.

Pair Name	Nobiletin, Vorinostat
Phytochemical	Nobiletin
Drug	Vorinostat
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The combination of nobiletin with vorinostat increased histone H3K9 and H3K27 acetylation levels in SCLC mouse tumor tissue and enhanced the expression of the BH3-only proteins BIM and BID. We conclude that nobiletin is a novel natural BH3 mimetic that can cooperate with vorinostat to induce apoptosis and autophagy in SCLC.

Pair Name	Noscapine, Cisplatin
Phytochemical	Noscapine
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our results suggest that Nos enhanced the anticancer activity of Cis in an additive to synergistic manner by activating multiple signaling pathways including apoptosis. These findings suggest potential benefit for use of Nos and Cis combination in treatment of lung cancer.

Pair Name	Noscapine, Gemcitabine
Phytochemical	Noscapine
Drug	Gemcitabine
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Nos potentiated the anticancer activity of Gem in an additive to synergistic manner against lung cancer via antiangiogenic and apoptotic pathways. These findings suggest potential benefit for use of NGC chemotherapy for treatment of lung cancer.

Pair Name	Noscapine, Gemcitabine
Phytochemical	Noscapine
Drug	Gemcitabine
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Nos potentiated the anticancer activity of Gem in an additive to synergistic manner against lung cancer via antiangiogenic and apoptotic pathways. These findings suggest potential benefit for use of NGC chemotherapy for treatment of lung cancer.

Pair Name	Oridonin, Venetoclax
Phytochemical	Oridonin
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Oridonin and venetoclax synergistically promote AML cell apoptosis by inhibiting AKT signaling.

Pair Name	Oroxylin A, Fluorouracil
Phytochemical	Oroxylin A
Drug	Fluorouracil
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The anti-hepatocellular carcinoma effects in vitro and in vivo of 5-FU and oroxylin A combinations were synergistic and oroxylin A increased the sensitivity of HepG2 cells to 5-FU by modulating the metabolic enzymes of 5-FU and apoptotic-related proteins

Pair Name	Oxidized tea polyphenol, Nimotuzumab
Phytochemical	Oxidized tea polyphenol
Drug	Nimotuzumab
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	OTP-3 can also serve as an effective therapeutic agent in NSCLC where it can augment the effects of nimotuzumab, a valuable property for combination agents.

Pair Name	Oxymatrine, Paclitaxel
Phytochemical	Oxymatrine
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model

Pair Name	Parthenolide, Balsalazide
Phytochemical	Parthenolide
Drug	Balsalazide
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results demonstrate that parthenolide potentiates the efficacy of balsalazide through synergistic inhibition of NF-κB activation and the combination of dual agents prevents colon carcinogenesis from chronic inflammation.

Pair Name	Peiminine, Doxorubicin
Phytochemical	Peiminine
Drug	Doxorubicin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our findings indicated that sinapine played an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells.

Pair Name	Periplocin, Gemcitabine
Phytochemical	Periplocin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells

Pair Name	Phenethyl isothiocyanate, Gefitinib
Phytochemical	Phenethyl isothiocyanate
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	We explored the prospect of PEITC in improving the efficacy of targeted drug therapy and demonstrated the synergistic effects and underlined mechanisms of PEITC combined with Gefitinib in NSCLC cells treatment. This study provided useful information for developing novel therapy strategies by combination treatment of PEITC with targeted drugs.

Pair Name	Phenethyl isothiocyanate, Irinotecan
Phytochemical	Phenethyl isothiocyanate
Drug	Irinotecan
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	PEITC potentiates IRI anticancer activity by promoting cell apoptosis in the human colon HCT 116 cells. Thus, PEITC may be a potential enhancer for IRI in humans as an anticolon cancer drug in the future.

Pair Name	Phorbol 12-myristate 13-acetate, Apicularen A
Phytochemical	Phorbol 12-myristate 13-acetate
Drug	Apicularen A
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	These results suggest that the synergy between PMA and apicularen A is involved by PKCα activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer.

Pair Name	Piceatannol, Shikonin
Phytochemical	Piceatannol
Drug	Shikonin
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results indicate that concomitant use of low-dose shikonin potentiates piceatannol-induced apoptosis of GLO I-dependent cancer cells by augmenting methylglyoxal accumulation.

Pair Name	Piperlongumine, Bortezomib
Phytochemical	Piperlongumine
Drug	Bortezomib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Piperlongumine and bortezomib synergically inhibit cholangiocarcinoma via ER stress-induced cell death

Pair Name	Piperlongumine, Sorafenib
Phytochemical	Piperlongumine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer

Pair Name	Platycodin D, Sorafenib
Phytochemical	Platycodin D
Drug	Sorafenib
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The combination of Platycodin D and sorafenib may exert potent anti-cancer effects specifically via FOXO3a

Pair Name	Platycodin D, Venetoclax
Phytochemical	Platycodin D
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Platycodin D may be a potent therapeutic candidate for the treatment of AML

Pair Name	Polydatin, Paclitaxel
Phytochemical	Polydatin
Drug	Paclitaxel
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Polydatin may enhance the chemosensitivity of osteosarcoma cells to paclitaxel.

Pair Name	Polyphyllin I, Cisplatin
Phytochemical	Polyphyllin I
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The results from the present study demonstrated that PPI and PPVII may function as chemosensitizers by enhancing apoptosis via the p53 pathway, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis, and the combination with DDP may be a promising strategy for the development of new therapeutic agents.

Pair Name	Propyl gallate, Cisplatin
Phytochemical	Propyl gallate
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our data provide the potential application of PG in combination chemotherapy to enhance drug sensitivity in lung cancer by targeting HO-1.

Pair Name	Pterostilbene, Fluorouracil
Phytochemical	Pterostilbene
Drug	Fluorouracil
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results provide a rationale for novel combination treatment strategies, especially for patients with 5-FU-resistant tumors expressing ER-β protein.

Pair Name	Pterostilbene, Sorafenib
Phytochemical	Pterostilbene
Drug	Sorafenib
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	PET obviously enhanced sorafenib's antitumour effects against GAC through inhibiting cell proliferation, inducing autophagy and promoting apoptosis. The combination therapy with PET and sorafenib may serve as a novel therapeutic strategy for treating GAC and deserve further clinical trials.

Pair Name	Pterostilbene, TNF-related apoptosis inducing ligand
Phytochemical	Pterostilbene
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Pterostilbene enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistance triple negative breast cancer cells

Pair Name	Quercetin, Cisplatin
Phytochemical	Quercetin
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This study provides further new data for the mechanism by which the QU pre-treatment re-sensitizes SKOV-3/CDDP cells to cisplatin.

Pair Name	Quercetin, Oxaliplatin
Phytochemical	Quercetin
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings suggest that the depletion of intracellular glutathione by quercetin and sulforaphane could strengthen the anti-cancer efficacy of oxaliplatin.

Pair Name	Resveratrol, Cisplatin
Phytochemical	Resveratrol
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results indicated that RES is a promising adjuvant for DDP during GC chemotherapy.

Pair Name	Resveratrol, Cisplatin
Phytochemical	Resveratrol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT

Pair Name	Resveratrol, Olaparib
Phytochemical	Resveratrol
Drug	Olaparib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	RES + OLA combination treatment enhanced breast cancer cell death by causing excessive DNA damage and also simultaneously inhibiting the HR pathway.

Pair Name	Resveratrol, Temozolomide
Phytochemical	Resveratrol
Drug	Temozolomide
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	TMZ-induced ROS/ERK-mediated autophagy protected glioma cells from apoptosis, and the combination of resveratrol with TMZ could improve the efficacy of chemotherapy for brain tumors.

Pair Name	Saikosaponin D, Cisplatin
Phytochemical	Saikosaponin D
Drug	Cisplatin
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results suggest that saikosaponins sensitize cancer cells to cisplatin through ROS-mediated apoptosis, and the combination of saikosaponins with cisplatin could be an effective therapeutic strategy.

Pair Name	Sanguinarium, Bortezomib
Phytochemical	Sanguinarium
Drug	Bortezomib
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our findings demonstrate that SNG induces mitochondrial and caspase-dependent apoptosis, generates oxidative stress, and suppresses MM cell lines proliferation. In addition, co-treatment of MM cell lines with sub-toxic doses of SNG and BTZ potentiated the cytotoxic activity. These results would suggest that SNG could be developed into therapeutic agent either alone or in combination with other anticancer drugs in MM.

Pair Name	Sclareolide, Gemcitabine
Phytochemical	Sclareolide
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer

Pair Name	Scutellarin, Cisplatin
Phytochemical	Scutellarin
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our study supports that scutellarin acts as a potential sensitizer to cisplatin treatment and the combination of scutellarin and cisplatin may be a novel therapeutic strategy to overcome platinum resistance of ovarian cancer.

Pair Name	Se-Methylselenocysteine, Gemcitabine
Phytochemical	Se-Methylselenocysteine
Drug	Gemcitabine
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Antitumor study in Ehrlich solid tumor model showed the efficacy of MSC combination with GEM for the enhanced antitumor activity. The proposed combination demonstrated the potential for further translational studies.

Pair Name	Shikonin, 4-hydroxytamoxifen
Phytochemical	Shikonin
Drug	4-hydroxytamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The combination of SK and 4-OHT shows highly efficient anticancer effects on breast cancer therapy. SK may be a promising candidate as an adjuvant to 4-OHT for breast cancer treatments, especially for ER- breast cancer.

Pair Name	Shikonin, BEZ235
Phytochemical	Shikonin
Drug	BEZ235
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	We found that low doses shikonin and dual PI3K-mTOR inhibitor (BEZ235) have a synergistic effect that inhibits the spheroid formation from chemoresistant lung cancer sublines. Inhibiting the proliferation of lung cancer stem cells is believed to reduce the recurrence of lung cancer; therefore, shikonin's anti-drug resistance and anti-cancer stem cell activities make it a highly interesting molecule for future combined lung cancer therapy.

Pair Name	Shogaol, Gemcitabine
Phytochemical	Shogaol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10.0]	Pancreatic ductal adenocarcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our results suggest that 6-shogaol can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing of TLR4/NF-κB-mediated inflammatory pathways linked to tumorigenesis.

Pair Name	Silibinin, Paclitaxel
Phytochemical	Silibinin
Drug	Paclitaxel
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines

Pair Name	Silibinin, Sorafenib
Phytochemical	Silibinin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These results suggested that silibinin improved the efficacy of sorafenib in HCC therapy, indicating a clinical promising therapeutic strategy for HCC patients.

Pair Name	Solamargine, Cisplatin
Phytochemical	Solamargine
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Identification of solamargine as a cisplatin sensitizer through phenotypical screening in cisplatin-resistant NSCLC organoids

Pair Name	Sulforaphane, Cisplatin
Phytochemical	Sulforaphane
Drug	Cisplatin
Disease Info	[ICD-11: 2C28]	Malignant mesothelioma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells

Pair Name	Sulforaphene, Carboplatin
Phytochemical	Sulforaphene
Drug	Carboplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This study demonstrates that the duel character of this combination therapy may be an effective replacement for conventional therapy alone against NSCLC.

Pair Name	Tangeretin, Fluorouracil
Phytochemical	Tangeretin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	To our knowledge gained from literature, this study is the first to describe synergistic activity of TAN and 5-FU against colorectal cancer cells.

Pair Name	Tangeretin, Metformin
Phytochemical	Tangeretin
Drug	Metformin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The current work underscores the importance of metformin as an ERMA in tackling breast cancer and as a novel approach to boost its anticancer activity via a synergistic combination with tangeretin.

Pair Name	Tetrandrine, Cisplatin
Phytochemical	Tetrandrine
Drug	Cisplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo

Pair Name	Tetrandrine, Sorafenib
Phytochemical	Tetrandrine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The antitumour activity of sorafenib plus tetrandrine may be attributed to the induction of the intrinsic apoptosis pathway through ROS/Akt signaling. This finding provides a novel approach that may broaden the clinical application of sorafenib.

Pair Name	Toosendanin, Paclitaxel
Phytochemical	Toosendanin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	The results suggest that combination of TSN and PTX is superior to PTX alone, suggesting that it may be a promising alternative adjuvant chemotherapy strategy for patients with TNBC, especially those with metastatic TNBC.

Pair Name	Trigonelline, Cisplatin
Phytochemical	Trigonelline
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our study demonstrated that Trigonelline blocks Nrf2 activation and its nuclear translocation via inhibition of EGFR signalling pathway. It has improved responsiveness of NSCLC cells for Cisplatin and Etoposide and could be a promising choice for lung cancer therapy. Toxicol In Vitro. 2021 Feb;70:105038. doi: 10.1016/j.tiv.2020.105038.

Pair Name	Tubeimoside I, Temozolomide
Phytochemical	Tubeimoside I
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	We first demonstrated that synergistic effects of TBMS1 and TMZ induced apoptosis in GBM cells through reducing MGMT expression and inhibiting the EGFR induced PI3K/Akt/mTOR/NF-κB signaling pathway. This study provides a rationale for combined application of TMZ and TBMS1 as a potential chemotherapeutic treatment for MGMT+ GBM patients.

Pair Name	Ursolic acid, Cisplatin
Phytochemical	Ursolic acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The combination of UA with DDP could more effectively inhibit SiHa cells proliferation and facilitate cell apoptosis through suppressing NF-κB p65.

Pair Name	Ursolic acid, Doxorubicin
Phytochemical	Ursolic acid
Drug	Doxorubicin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	UA may be a novel anticancer strategy and could be considered for investigation as a complementary chemotherapy agent in the future.

Pair Name	Ursolic acid, Sorafenib
Phytochemical	Ursolic acid
Drug	Sorafenib
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	These results suggest that the synergistic antitumor effects of sorafenib combined with ursolic acid may involve the induction of Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis. Our findings may offer a novel effective therapeutic strategy for tumor treatment.

Pair Name	Vanillin, Fluorouracil
Phytochemical	Vanillin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Vanillin is deemed to be a promising anticancer candidate by inhibiting NNMT and may attenuate NNMT‑induced resistance to 5‑Fu in human CRC therapy with few side effects.

Pair Name	Voacamine, Paclitaxel
Phytochemical	Voacamine
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Our data show the specific effect of VOA which only works on drugs known to be substrates of P-gp.

Pair Name	Withaferin A, Sorafenib
Phytochemical	Withaferin A
Drug	Sorafenib
Disease Info	[ICD-11: 2D10.Z]	Thyroid cancer		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Combination therapy with sorafenib + withaferin showed synergistic efficacy in papillary and anaplastic cancers in vitro with significant induction of apoptosis. This combination achieved potent anticancer activity with lower overall doses of sorafenib, indicating a potential strategy to decrease sorafenib toxicity in future translational studies.

Pair Name	Wogonin, Cisplatin
Phytochemical	Wogonin
Drug	Cisplatin
Disease Info	Head and neck cancer
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Wogonin induced selective cell death by targeting the antioxidant defense mechanisms enhanced in the resistant HNC cells and activating cell death pathways involving PUMA and PARP. Hence, wogonin significantly sensitized resistant HNC cells to cisplatin both in vitro and in vivo. Wogonin is a promising anticancer candidate that induces ROS accumulation and selective cytotoxicity in HNC cells and can help to overcome cisplatin-resistance in this cancer.

Pair Name	2,3,5,6-Tetramethylpyrazine, Cisplatin
Phytochemical	2,3,5,6-Tetramethylpyrazine
Drug	Cisplatin
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	A series of ligustrazine-derived chalcones-modified platinum(IV) complexes were synthesized and evaluated for their anti-proliferative potency and generated an optimal platinum(IV) complex 16a. The above-described results indicated that 16a obtained different anti-cancer mechanisms of CDDP, which could initiate mitochondria-dependent apoptosis and xCT-GPX4 axial-mediated ferroptosis in PANC-1/CDDP cells.

Pair Name	Artesunate, Venetoclax
Phytochemical	Artesunate
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	We provide a new triple combination for AML treatment by targeting the Noxa/Mcl-1/Bim axis to reverse Mcl-1/p-Chk1 resistance of cytarabine therapy.

Pair Name	Cepharanthine, Cisplatin
Phytochemical	Cepharanthine
Drug	Cisplatin
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals

Pair Name	Curcumol, TNF-related apoptosis inducing ligand
Phytochemical	Curcumol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers.

Pair Name	Decursin, Doxorubicin
Phytochemical	Decursin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	AGN would be a potentially novel treatment option for multidrug-resistant tumors by sensitizing to anticancer agents.

Pair Name	Honokiol, Metformin
Phytochemical	Honokiol
Drug	Metformin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The combination of honokiol with metformin is considered an effective approach to induce death in hormone-resistant cells. Honokiol is of interest as a natural compound with antiproliferative activity against breast cancers, including resistant tumors.

Pair Name	Kaempferol, Cisplatin
Phytochemical	Kaempferol
Drug	Cisplatin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

Pair Name	Liquiritin, Cisplatin
Phytochemical	Liquiritin
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo

Pair Name	Mitocurcumin, Cytarabine
Phytochemical	Mitocurcumin
Drug	Cytarabine
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	The data suggest that MitoC exploits stress-induced leukemic oxidative environment to up-regulate JNK/p38 signaling to lead to apoptosis and can potentially overcome Cytarabine resistance via ROS/p21/CHK1 axis.

Pair Name	Morin Hydrate, Cisplatin
Phytochemical	Morin Hydrate
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	The combination of Morin hydrate with cisplatin may be a promising therapeutic strategy to enhance the efficacy of conventional chemotherapeutic drugs.

Pair Name	Oleanolic Acid, Cisplatin
Phytochemical	Oleanolic Acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	OLO-2 treatment also exhibited up to 4.6-fold selectivity against human lung adenocarcinoma cells. Taken together, the results of the present study shed light on the drug resistance-reversing effects of OLO-2 in lung cancer cells.

Pair Name	Parthenolide, Temozolomide
Phytochemical	Parthenolide
Drug	Temozolomide
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	These findings suggest that NF-κB is a potential target for inducing cell death in gliomas. A targeted combination strategy in which the response to TMZ is synergistically enhanced by the addition of parthenolide which may be useful, especially in chemoresistant gliomas with high MGMT expression.

Pair Name	Scutellarin, Cisplatin
Phytochemical	Scutellarin
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This study identifies the unique role of scutellarin in reversing cisplatin resistance through apoptosis and autophagy, and suggests that combined cisplatin and scutellarin might be a novel therapeutic strategy for patients with NSCLC.

Pair Name	Shikonin, Gefitinib
Phytochemical	Shikonin
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Expression
Result	Shikonin-induced cell apoptosis is closely associated with ROS elevation in the cells. These findings indicate that Shikonin can be an effective small molecule treating gefitinib-resistant NSCLC.

Pair Name	Shogaol, TNF-related apoptosis inducing ligand
Phytochemical	Shogaol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	This study gives rise to the possibility of applying shogaol as an antitumor agent that can be used for the purpose of combination treatment with TRAIL in TRAIL-resistant colon tumor therapy.

Pair Name	Vinpocetine, Sorafenib
Phytochemical	Vinpocetine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Poly [ADP-ribose] polymerase 1		Cleavage
Result	Vinpocetine may be a potential candidate for sorafenib sensitization and HCC treatment, and our results may help to elucidate more effective therapeutic options for HCC patients with sorafenib resistance.