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2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-1-benzopyrylium, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one, 3,3',4',7-Tetrahydroxy-flavone, 3,3',4',7-Tetrahydroxyflavone, 5-Desoxy-quercetin, fisetin, fisetinidin

No.	Title	Href
1	Co-encapsulation of fisetin and cisplatin into liposomes: Stability considerations and in vivo efficacy on lung cancer animal model. Int J Pharm. 2024 Feb 15;651:123744. doi: 10.1016/j.ijpharm.2023.123744.	`Click`
2	Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer. Int J Cancer. 2019 Dec 1;145(11):3022-3032. doi: 10.1002/ijc.32367.	`Click`
3	Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma. Oncotarget. 2016 Jan 12;7(2):1227-41. doi: 10.18632/oncotarget.6237.	`Click`
4	Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway. Tumour Biol. 2016 May;37(5):6987-96. doi: 10.1007/s13277-015-4526-4.	`Click`
5	Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells. Oncotarget. 2015 Sep 29;6(29):28296-311. doi: 10.18632/oncotarget.5064.	`Click`
6	The effect of paclitaxel- and fisetin-loaded PBM nanoparticles on apoptosis and reversal of drug resistance gene ABCG2 in ovarian cancer. J Ovarian Res. 2023 Nov 21;16(1):220. doi: 10.1186/s13048-023-01308-w.	`Click`

No.

Title

Href

Co-encapsulation of fisetin and cisplatin into liposomes: Stability considerations and in vivo efficacy on lung cancer animal model. Int J Pharm. 2024 Feb 15;651:123744. doi: 10.1016/j.ijpharm.2023.123744.

Click

Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer. Int J Cancer. 2019 Dec 1;145(11):3022-3032. doi: 10.1002/ijc.32367.

Click

Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma. Oncotarget. 2016 Jan 12;7(2):1227-41. doi: 10.18632/oncotarget.6237.

Click

Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway. Tumour Biol. 2016 May;37(5):6987-96. doi: 10.1007/s13277-015-4526-4.

Click

Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells. Oncotarget. 2015 Sep 29;6(29):28296-311. doi: 10.18632/oncotarget.5064.

Click

The effect of paclitaxel- and fisetin-loaded PBM nanoparticles on apoptosis and reversal of drug resistance gene ABCG2 in ovarian cancer. J Ovarian Res. 2023 Nov 21;16(1):220. doi: 10.1186/s13048-023-01308-w.

Click

Name	Fisetin
PubChem CID	5281614
Molecular Weight	286.24g/mol
Synonyms	2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-1-benzopyrylium, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one, 3,3',4',7-Tetrahydroxy-flavone, 3,3',4',7-Tetrahydroxyflavone, 5-Desoxy-quercetin, fisetin, fisetinidin
Formula	C₁₅H₁₀O₆
SMILES	C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O
InChI	1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
InChIKey	XHEFDIBZLJXQHF-UHFFFAOYSA-N
CAS Number	528-48-3
ChEMBL ID	CHEMBL31574
ChEBI ID	CHEBI:42567
Herb ID	HBIN026506
Drug Bank ID	DB07795
KEGG ID	C10041
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	ErCha
Use Part	Peeled Branches And Trunks
Habitat	YunNan, GuangDong, GuangXi, FuJian
Flavor	Bitter, Astringent
Meridian Tropism	Lung, Heart

Chineses Pinyin	JiangXiang
Use Part	Dried Heartwood Of Tree Trunk And Root
Habitat	HaiNan, GuangDong, GuangXi, YunNan
Flavor	Pungent
Meridian Tropism	Liver, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Dalbergia 　　　　　　-->Species: Dalbergia odorifera

Chineses Pinyin	ZaoJiaoCi
Use Part	Thorn
Habitat	JiangSu, HuBei, HeBei, ShanXi, HeNan, ShanDong, GuangDong, GuangXi, SiChuan, AnHui, ZheJiang, GuiZhou, Shaanxi, JiangXi, GanSu
Flavor	Pungent
Meridian Tropism	Liver, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Gleditsia 　　　　　　-->Species: Gleditsia sinensis

Chineses Pinyin	JuanBai
Use Part	Dried Whole Herb
Habitat	China
Flavor	Pungent
Meridian Tropism	Liver, Heart

Chineses Pinyin	MangGuoYe
Use Part	Leaf
Habitat	FuJian, TaiWan, GuangDong, HaiNan, GuangXi, YunNan
Flavor	Mildly sour
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Anacardiaceae 　　　　　-->Genus: Mangifera 　　　　　　-->Species: Mangifera indica

Chineses Pinyin	LinBeiZi
Use Part	Root, Root Cortex
Habitat	SiChuan, GuiZhou, YunNan, XiZang, ChongQing, JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeBei, HeNan
Flavor	Bitter
Meridian Tropism	Heart, Liver, Spleen

Chineses Pinyin	YeQiShuYe
Use Part	Leaf
Habitat	JiangSu, ZheJiang, AnHui, FuJian, TaiWan, JiangXi, HuBei, HuNan, GuiZhou, SiChuan
Flavor	Pungent
Meridian Tropism	Lung, Liver, Spleen, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Anacardiaceae 　　　　　-->Genus: Toxicodendron 　　　　　　-->Species: Toxicodendron succedaneum

Chineses Pinyin	CaoMei
Use Part	Fruit
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Rosaceae 　　　　　-->Genus: Fragaria 　　　　　　-->Species: Fragaria × ananassa

Pair Name	Fisetin, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	AKT1S1	hsa84335
	Down-regulation	Phosphorylation	EIF4E	KEGG ID N.A.
	Down-regulation	Phosphorylation	EIF4EBP1	hsa1978
	Down-regulation	Expression	MLST8	KEGG ID N.A.
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Down-regulation	Expression	PIK3CA	hsa5290
	Up-regulation	Phosphorylation	PRKAA1	hsa5562
	Down-regulation	Expression	RICTOR	hsa253260
	Down-regulation	Phosphorylation	RPS6KB1	hsa6198
	Down-regulation	Expression	RPTOR	hsa57521
In Vitro Model	SW480	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0546
	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
In Vivo Model	Since FC13K1ApcMin/+ mice develop adenomas around 1 month of age, the treatment with fisetin and 5-FU by intraperitoneal injection was started between 26 and 30 days.
Result	Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer

Pair Name	Fisetin, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	FN1	hsa2335
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	SNAI1	hsa6615
	Down-regulation	Expression	SNAI2	hsa6591
	Down-regulation	Expression	TWIST1	hsa7291
	Down-regulation	Expression	VIM	hsa7431
	Down-regulation	Expression	ZEB1	hsa6935
In Vitro Model	A-375	Amelanotic melanoma	Homo sapiens (Human)	CVCL_0132
In Vitro Model	SK-MEL-28	Cutaneous melanoma	Homo sapiens (Human)	CVCL_0526
In Vivo Model	Female athymic nude mice of five weeks age were subcutaneously transplanted with A375 or SK-MEL-28 cells (2.5×10⁶ A375 cells in 50 ul DMEM + 50 ul matrigel or 5×10⁶ SK-MEL-28 cells in 50 ul RPMI + 50 ul matrigel) in each flank
Result	Our findings demonstrate that fisetin potentiates the anti-invasive and anti-metastatic effects of sorafenib. Our data suggest that fisetin may be a worthy adjuvant chemotherapy for the management of melanoma.

Pair Name	Fisetin, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ABCG2	hsa9429
	Up-regulation	Expression	BAK1	hsa578
	Down-regulation	Expression	BCL-xL	hsa598
	Up-regulation	Activity	CASP3	hsa836
In Vitro Model	OVCAR-3	High grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_0465
	Caov-3	High grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_0201
	TOV-112D	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_3612
	SW626	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_1725
Result	Our study shows that PTX-FA and Fis-FA PBM NPs directly target platinum-resistant OvCa cells, induce cytotoxic/apoptotic effects, and reverse multi-drug resistance (MDR). These findings allow us to create new clinical applications using PTX-FA and Fis-FA combination nanoparticles to treat drug-resistant cancers.

Pair Name	Fisetin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
In Vitro Model	LL/2 (LLC1)	Malignant tumors of the mouse pulmonary system	Mus musculus (Mouse)	CVCL_4358
In Vivo Model	Female 6-weeks old C57BL/6J mice were used for anti-tumor evaluation. Lewis lung tumor fragments (about 30 mm3) were injected subcutaneously (s.c.) bilaterally into the flanks of the mice (day 1).
Result	The combination index between liposomal fisetin and liposomal cisplatin on 3LL cell line after 24 h of exposure showed a clear synergism: CI = 0.7 for the co loaded liposomes and CI = 0.9 for the mixture of cisplatin loaded and fisetin loaded liposomes. The co-encapsulating formulation showed in vivo efficacy against an ectopic murine model of Lewis Lung carcinoma with a probable reduction in the toxicity of cisplatin through co-encapsulation with fisetin.