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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name AMG-951
Drug Type Not Available
Toxicity Organism Test Type Route(Dose)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 450
Ref_1
Pair Name Naringenin, AMG-951
Partner Name Naringenin
Disease Info [ICD-11: 2F7Z] Glioma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAD hsa572
Up-regulation Expression BAK1 hsa578
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP8 hsa841
Up-regulation Cleavage CASP9 hsa842
Up-regulation Expression CDKN1A hsa1026
Up-regulation Cleavage PARP1 hsa142
Up-regulation Expression TNFRSF10A hsa8797
Up-regulation Expression TNFRSF10B hsa8795
Up-regulation Expression TP53 hsa7157
Up-regulation Expression TRADD hsa8717
In Vitro Model LN-308 Astrocytoma Homo sapiens (Human) CVCL_0394
U-251MG Astrocytoma Homo sapiens (Human) CVCL_0021
In Vivo Model 5×10⁵ U251-MG cells were subcutaneously injected into the dorsal flanks of mice.
Result The present study provides a novel therapeutic strategy for glioma by potentiating APO2L-induced apoptosis via the combination with NG in glioma tumor cells.
03. Reference
No. Title Href
1 Glioma progression is suppressed by Naringenin and APO2L combination therapy via the activation of apoptosis in vitro and in vivo. Invest New Drugs. 2020 Dec;38(6):1743-1754. doi: 10.1007/s10637-020-00979-2. Click
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