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beta-D-glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, flavone, 4',5,6,7-tetrahydroxy-, 7-beta-D-glucopyranuronoside, scutellarein 7-beta-D-glucuronide, scutellarein 7-beta-D-glucuronoside, scutellarein 7-glucuronide, scutellarein 7-O-beta-D-glucuronide, scutellarein-7-O-beta-glucuronide, scutellarein-7-O-glucuronide, scutellarin, scutellarin B

No.	Title	Href
1	Scutellarin resensitizes oxaliplatin-resistant colorectal cancer cells to oxaliplatin treatment through inhibition of PKM2. Mol Ther Oncolytics. 2021 Mar 17;21:87-97. doi: 10.1016/j.omto.2021.03.010.	`Click`
2	Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA. Eur J Pharmacol. 2019 Feb 5;844:9-16. doi: 10.1016/j.ejphar.2018.11.040.	`Click`
3	Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways. Front Pharmacol. 2018 Feb 13;9:92. doi: 10.3389/fphar.2018.00092.	`Click`

No.

Title

Href

Scutellarin resensitizes oxaliplatin-resistant colorectal cancer cells to oxaliplatin treatment through inhibition of PKM2. Mol Ther Oncolytics. 2021 Mar 17;21:87-97. doi: 10.1016/j.omto.2021.03.010.

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Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA. Eur J Pharmacol. 2019 Feb 5;844:9-16. doi: 10.1016/j.ejphar.2018.11.040.

Click

Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways. Front Pharmacol. 2018 Feb 13;9:92. doi: 10.3389/fphar.2018.00092.

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Name	Scutellarin
PubChem CID	185617
Molecular Weight	462.4g/mol
Synonyms	beta-D-glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, flavone, 4',5,6,7-tetrahydroxy-, 7-beta-D-glucopyranuronoside, scutellarein 7-beta-D-glucuronide, scutellarein 7-beta-D-glucuronoside, scutellarein 7-glucuronide, scutellarein 7-O-beta-D-glucuronide, scutellarein-7-O-beta-glucuronide, scutellarein-7-O-glucuronide, scutellarin, scutellarin B
Formula	C₂₁H₁₈O₁₂
SMILES	C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O)O
InChI	1S/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1
InChIKey	DJSISFGPUUYILV-ZFORQUDYSA-N
CAS Number	27740-01-8
ChEMBL ID	CHEMBL487805
ChEBI ID	CHEBI:61278
Herb ID	HBIN043533
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	BanZhiLian
Use Part	Whole Grass
Habitat	GuangDong, ZheJiang, FuJian, TaiWan, GuangXi, HaiNan
Flavor	Pungent, Bitter
Meridian Tropism	Lung, Liver, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Scutellaria 　　　　　　-->Species: Scutellaria barbata

Chineses Pinyin	BaiSu
Habitat	JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing
Flavor	Pungent
Meridian Tropism	Lung, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Perilla 　　　　　　-->Species: Perilla frutescens

Chineses Pinyin	ChouMoLi
Use Part	Root, Leaf
Habitat	GuangXi, GuiZhou, YunNan
Flavor	Bitter
Meridian Tropism	Heart, Spleen, Kidney

Chineses Pinyin	DaCheQian
Use Part	Whole Herb
Habitat	China
Flavor	Sweet
Meridian Tropism	Liver, Kidney, Bladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Plantaginaceae 　　　　　-->Genus: Plantago 　　　　　　-->Species: Plantago major

Chineses Pinyin	DengZhanHua
Use Part	Whole Herb
Habitat	HuBei, HuNan, GuangXi, GuiZhou, SiChuan, YunNan, XiZang
Flavor	Pungent, Mildly bitter
Meridian Tropism	Heart, Liver

Chineses Pinyin	DengZhanXiXin
Use Part	Whole Herb
Habitat	HuBei, HuNan, GuangXi, GuiZhou, SiChuan, YunNan, XiZang
Flavor	Pungent, Mildly bitter
Meridian Tropism	Heart, Liver

Chineses Pinyin	HuangQin
Use Part	Root
Habitat	HeiLongJiang, LiaoNing, NeiMengGu, HeBei, HeNan, GanSu, Shaanxi, ShanXi, ShanDong, SiChuan
Flavor	Bitter
Meridian Tropism	Lung; Large Intestine; Stomach; Small Intestine; Gallbladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Scutellaria 　　　　　　-->Species: Scutellaria baicalensis

Pair Name	Scutellarin, Oxaliplatin
Partner Name	Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Mitochondrial apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Activity	PKM	hsa5315
In Vitro Model	SW480	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0546
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	It was indicated that scutellarin resensitizes oxaliplatin-resistant CRC cells to oxaliplatin treatment through inhibition of PKM2.

Pair Name	Scutellarin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
Gene Regulation	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	OVCAR-3	High grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_0465
In Vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens (Human)	CVCL_0532
Result	Our study supports that scutellarin acts as a potential sensitizer to cisplatin treatment and the combination of scutellarin and cisplatin may be a novel therapeutic strategy to overcome platinum resistance of ovarian cancer.