In the field of "Search for anticancer drug", user can find anticancer drug entries by searching drug name, disease name, molecule name, target name and so on among the entire textual component of InterPAD. Query can be submitted by entering keywords into the main searching frame. The resulting webpage displays profiles of all the drugs directly related to the search term, including Drug structure, Drug name, Disease, Highest Status, PubChem CID, Interaction Partner, Drug Type, Target and Drug information link.

1. If search "Gemcitabine", find a single entry which is named "Gemcitabine";
2. If search: "HMOX1", finds 14 entries with drug names;
3. If search: "Ovarian cancer", find 5 entries with drug names;
4. If search: "RRM2", find a single entry which is named "Gemcitabine".

For example, if you want to know the detail information of drug, you can search "Gemcitabine" in the "Search for Drug Entries" field.

Search result of the "Gemcitabine" shows the information of Drug structure, Drug Name, PubChem CID, Drug Indication, Clinical Status, Interaction Partner, Drug Type, Target name and External buttons. The Drug name button links to the detailed Drug information page of Gemcitabine. The Interaction Partner button links to the detailed Interaction information page of Gemcitabine.

If you want to know the detail information of Drug, which regulates "HMOX1", you can select "HMOX1" in the "Search for Anticancer Drug by Regulated Molecule" field.

If you want to know the detail information of Drug, which used to treat "Ovarian cancer", you can select "[ICD-11: 2C73]: Ovarian cancer" in the "Search for Anticancer Drug by Disease" field.

If you want to know the detail information of Drug, which targets "RRM2", you can select "RRM2" in the "Search for Anticancer Drug by Target" field.

Take Gemcitabine as an example, "General Information of the Drug" section displays the general information of Gemcitabine including its Name, PubChem CID, Molecular weight, Drug Type, Formula, SMILES, InChI, InChIKey, CAS number, ChEBI ID, TTD ID, KEGG ID, Toxicity, Structure, and External Link(s).

Enhance the efficacy of anticancer drug by this interaction displays the specific interaction effect and experiment report. The followings are specific combinatorial therapeutic effect(s) and representative experiment report, including Pair Name, Partner Name, Disease Info, Biological Phenomena, Gene Regulation, In Vitro Model, In Vivo Model, Experimental Result(s). Pair Name button links to the detail information page with the interaction. Partner Name button links to the detail information page with the drug. Molecule name button links to the detail information page with the molecule. Moreover, signaling pathway button can be clicked to show the signaling pathway of this interaction.

Reverse the resistance of drug by this interaction displays the specific interaction effect and experiment report, as presented above.

Take Beta-Sitosterol as an example, "General Information of the Drug Interaction" section displays the general information of Interaction including their Name, PubChem CID, Toxicity, 2D and 3D structures (downloadable in standard SDF format), and External Link(s).

"Combinatorial Therapeutic Effect(s)" section displays Interactions which can be decreased drug toxicity, which can be enhanced drug efficacy. The followings are specific combinatorial therapeutic effect(s) and representative experiment report, including Pair Name, Partner Name, Disease Info, Biological Phenomena, Gene Regulation, In Vitro Model, In Vivo Model, Experimental Result(s). Pair Name button links to the detail information page with the interaction. Partner Name button links to the detail information page with the drug. Molecule name button links to the detail information page with the molecule. Moreover, signaling pathway button can be clicked to show the signaling pathway of this interaction.

In the field of "Search for Drug Interaction", user can find drug entries by searching phytochemical name, drug name, molecule name, interaction effect and so on among the entire textual component of InterPAD. Query can be submitted by entering keywords into the main searching frame. The resulting webpage displays profiles of all the interactions directly related to the search term, including Interaction Pair, Interaction Effect, Disease, Highest Status and Interaction information link.

1. If search: "Epigallocatechin gallate, Irinotecan", find a single entry which is named "Epigallocatechin gallate, Irinotecan";
2. If search: "Epigallocatechin gallate", find 11 drug interaction entries that interact with epigallocatechin gallate;
3. If search: "Gemcitabine", find 62 phytochemical interaction entries that interact with Gemcitabine;
4. If search: "RRM2", find a single entry which is named "Gemcitabine";
5. If search: "Synergistic Effect: Decreasing Drug Toxicity", find 82 entries which were named "Synergistic Effect: Decreasing Drug Toxicity";

For example, if you want to know the detail information of drug interaction, you can select "Epigallocatechin gallate, Irinotecan" pair in the "Search for Interaction" field.

Search result of the "Epigallocatechin gallate, Irinotecan" shows the information of Pair Name, Interaction Effect, Disease Indication, Clinical Status, Interaction Partner, and External buttons. The Pair Name button links to the detailed Pair Name information page of Epigallocatechin gallate, Irinotecan. The Interaction Partner button links to the detailed Interaction information page of Epigallocatechin gallate or Irinotecan, respectively.

If you want to know the detail information of drug interaction, you can select "Epigallocatechin gallate" in the "Search for Interaction by Phytochemical" field.

If you want to know the detail information of drug interaction, you can select "Gemcitabine" in the "Search for Interaction by based on Drug" field.

If you want to know the detail information of drug interaction, which regulates "HMOX1", you can select "HMOX1" in the " Search for Interaction by Regulated Molecule" field.

If you want to know the detail information of drug interaction, you can select "Synergistic Effect: Decreasing Drug Toxicity" in the "Search for Interaction by Effect" field.

Take Epigallocatechin gallate, Irinotecan as an example, "General Information of the Pair" section displays the general information of pair including their Name, PubChem CID, 2D and 3D Structure, and External Link(s).

Decrease the toxicity of anticancer drug by this interaction displays the specific interaction effect and experiment report. Using "Artesunate, Fluorouracil" as an example, based on the theory of cold and heat, this theory was fully applied to anticancer drugs, and appropriate medicinal plants were selected within the guidelines to enhance the efficacy of this interaction and decrease the toxicity of fluorouracil. The followings are specific combinatorial therapeutic effect(s) and representative experiment report, including Pair Name, Partner Name, Disease Info, Biological Phenomena, Gene Regulation, In Vitro Model, In Vivo Model, Experimental Result. Molecule name button links to the detail information page with the molecule. Moreover, signaling pathway button can be clicked to show the signaling pathway of this interaction.

Enhance the efficacy of anticancer drug by this interaction displays the specific interaction effect and experiment report, and reduce the efficacy of drug by this interaction display the specific interaction effect and experiment report are the same as above.

Take Epigallocatechin gallate as an example, "General Information of the phytochemical" section displays the general information of Epigallocatechin gallate including its Name, PubChem CID, Molecular weight, Formula, SMILES, InChI, InChIKey, CAS number, ChEBI ID, TTD ID, HERB ID, KEGG ID, Toxicity, Structure and External Link(s).

Medicinal plant information related to this phytochemical source, "Source Information of Phytochemical" section highlighted in color after the medicinal plant name displays herbal natures (such as cold, hot, warm, cool and even). Other medicinal plant information includes Chineses Pinyin, use part, habitat, flavor, meridian tropism, classification (such as kingdom, phylum, class, order, family, genus, species).

Drug(s) whose efficacy can be enhanced by this phytochemical display the Drug(s) which combined by this phytochemical and the disease indication of Interaction(s). The followings are specific combinatorial therapeutic effect(s) and representative experiment report, including Pair Name, Partner Name, Disease Info, Biological Phenomena, Gene Regulation, In Vitro Model, In Vivo Model, Experimental Result(s). Pair Name button links to the detail information page with the interaction. Partner Name button links to the detail information page with the drug. Molecule name button links to the detail information page with the molecule. Moreover, signaling pathway button can be clicked to show the signaling pathway of this interaction.

Drug(s) whose resistance can be reversed by this phytochemical, Drug(s) whose toxicity can be decreased by this phytochemical, Drug(s) whose toxicity can be increased by this phytochemical and Drug(s) whose efficacy can be decreased by this phytochemical are the same as above.

Take Irinotecan as an example, "General Information of the Drug" section displays the general information of Irinotecan including its Name, PubChem CID, Molecular weight, Drug Type, Formula, SMILES, InChI, InChIKey, CAS number, ChEMBL ID, ChEBI ID, TTD ID, KEGG ID, Structure and External Link(s).

Enhance the efficacy of anticancer drug by this interaction displays the specific interaction effect and experiment report. The followings are specific combinatorial therapeutic effect(s) and representative experiment report, including Pair Name, Partner Name, Disease Info, Biological Phenomena, Gene Regulation, In Vitro Model, In Vivo Model, Experimental Result. Pair Name button links to the detail information page with the interaction. Partner Name button links to the detail information page with the drug. Molecule name button links to the detail information page with the molecule. Moreover, signaling pathway button can be clicked to show the signaling pathway of this interaction.

Reverse the resistance of anticancer drug by this interaction displays the specific interaction effect and experiment report, and reduce drug efficacy of anticancer drug by this Interaction display the specific interaction effect and experiment report are the same as above.

In the field of "Search for Disease", user can find drug combination entries, anticancer drug entries or phytochemical entries by selecting disease. The resulting webpage displays profiles of all the result directly related to the search term. ICD has been developed by the World Health Organization (WHO), sponsored by the United Nations, adopted by >110 countries and used by physicians, researchers, nurses, health workers, health information managers, policy makers, insurers and health program managers for defining and studying diseases, monitoring and managing health care and allocating resources.

For example, if you want to know the detail information of drug interaction, which used to treat "Colorectal cancer", you can select "[ICD-11: 2B91]: Colorectal cancer" in the "Search for Interactions by Disease" field.

The diagram shows interactions between diseases, phytochemicals and drugs, and the user can click on any shape according to their interest to view detailed information under that entry.

Search result of the "Colorectal cancer" shows the information of Disease Name, Disease ICD, Disease Class, Pair Name, Interaction Effect, Interaction Partner, and External buttons. The Pair Name button links to the detailed Pair Name information page of Baicalin, Fluorouracil. The Interaction Partner button links to the detailed Interaction information page of Baicalin or Fluorouracil, respectively.

If you want to know the detail information of phytochemical, which used to treat "Colorectal cancer", you can select "[ICD-11: 2B91]: Colorectal cancer" in the "Search for Phytochemical by Disease" field.

If you want to know the detail information of anticancer drug, which used to treat "Colorectal cancer", you can select "[ICD-11: 2B91]: Colorectal cancer" in the "Search for Drug by Disease" field.

Take "Baicalin, Fluorouracil" as an example, "General Information of the Pair" section displays the general information of pair including their Name, PubChem CID, 2D and 3D Structure, and External Link(s).

Enhance the efficacy of anticancer drug by this interaction displays the specific interaction effect and experiment report. The followings are specific combinatorial therapeutic effect(s) and representative experiment report, including Pair Name, Partner Name, Disease Info, Biological Phenomena, Gene Regulation, In Vitro Model, In Vivo Model, Experimental Result. Molecule name button links to the detail information page with the molecule. Moreover, signaling pathway button can be clicked to show the signaling pathway of this interaction.

Take Baicalin as an example, "General Information of the phytochemical" section displays the general information of Baicalin including its Name, PubChem CID, Molecular weight, Formula, SMILES, InChI, InChIKey, CAS number, ChEBI ID, TTD ID, HERB ID, KEGG ID, Toxicity, Structure and External Link(s).

Medicinal plant information related to this phytochemical source, "Source Information of Phytochemical" section highlighted in color after the medicinal plant name displays herbal natures (such as cold, hot, warm, cool and even). Other medicinal plant information includes Chineses Pinyin, use part, habitat, flavor, meridian tropism, classification (such as kingdom, phylum, class, order, family, genus, species).

Drug(s) whose efficacy can be enhanced by this phytochemical display the Drug(s) which combined by this phytochemical and the disease indication of Interaction(s). The followings are specific combinatorial therapeutic effect(s) and representative experiment report, including Pair Name, Partner Name, Disease Info, Biological Phenomena, Gene Regulation, In Vitro Model, In Vivo Model, Experimental Result(s). Pair Name button links to the detail information page with the interaction. Partner Name button links to the detail information page with the drug. Molecule name button links to the detail information page with the molecule. Moreover, signaling pathway button can be clicked to show the signaling pathway of this interaction.

Take Fluorouracil as an example, "General Information of the Drug" section displays the general information of Irinotecan including its Name, PubChem CID, Molecular weight, Drug Type, Formula, SMILES, InChI, InChIKey, CAS number, ChEMBL ID, ChEBI ID, TTD ID, KEGG ID, Toxicity, Structure, and External Link(s).

Enhance the efficacy of anticancer drug by this interaction displays the specific interaction effect and experiment report. The followings are specific combinatorial therapeutic effect(s) and representative experiment report, including Pair Name, Partner Name, Disease Info, Biological Phenomena, Gene Regulation, In Vitro Model, In Vivo Model, Experimental Result. Pair Name button links to the detail information page with the interaction. Partner Name button links to the detail information page with the drug. Molecule name button links to the detail information page with the molecule. Moreover, signaling pathway button can be clicked to show the signaling pathway of this interaction.

Reverse the resistance of anticancer drug by this interaction displays the specific interaction effect and experiment report, and reduce drug efficacy of anticancer drug by this interaction displays the specific interaction effect and experiment report are the same as above.

In the field of "Search for Molecule Entries", user can find molecule entries by searching molecule name or gene name among the entire textual component of InterPAD. Query can be submitted by entering keywords into the main searching frame. The resulting webpage displays profiles of all the molecules directly related to the search term, including Molecule name, Gene Name, Protein Name, UniProt ID, Family, Synonyms, information.

1. If search "STAT3", find a single entry which is named "STAT3";
2. If search: "Epigallocatechin gallate, Irinotecan", finds 10 entries with Gene names including "MAP1LC3B" or "BCL2" etc;
3. If search: "Epigallocatechin gallate ", finds 49 entries with regulated molecule names including "AKT1" or "BIRC5" etc;
4. If search: "Gemcitabine", finds 98 entries with regulated molecule names including "MAP1LC3B" or "ABCB1" etc;

For example, if you want to know the detail information of InterPAD for STAT3, you can search "STAT3" in the "Search for Molecule Entries" field.

Search result of the "STAT3" shows the information of Molecule name, Gene Name, Protein Name, UniProt ID, Family, Synonyms, and External buttons. The Gene Name button links to the detailed Gene Name information page of STAT3. The UniProt ID button links to the detailed Interaction information page of STAT3.

If you want to know the molecule detail information of drug interaction, you can select "Epigallocatechin gallate, Irinotecan" in the "Search for Molecule Regulated by Drug Interaction" field.

If you want to know the molecule detail information of phytochemical, you can select "Epigallocatechin gallate" in the "Search for Molecule Regulated by Phytochemical" field.

If you want to know the molecule detail information of drug, you can select " Gemcitabine" in the "Search for Molecule Regulated by Anticancer Drug" field.

Take STAT3 as an example, "General Information of the Pair" section displays the general information of the molecule including their Name, UniProt ID, Gene Name, Gene ID, Synonyms, Sequece, Pathway Map, T.C. Number, KEGG ID, TTD ID, and External Link(s).

A list of drug interaction (Decreasing Drug Toxicity) able to regulate this molecule display the specific interaction effect and experiment report. The followings are specific combinatorial therapeutic effect(s) and representative experiment report, including Pair Name, Phytochemical Name, Anticancer drug Name, Disease Info, Regulate Info, Experimental Result. Phytochemical Name button links to the detail information page with the phytochemical. Anticancer drug Name button links to the detail information page with the anticancer drug.

A list of drug interaction (Enhancing Drug Efficacy) able to regulate this molecule display the specific interaction effect and experiment report, and A list of drug interaction (Reversing Drug Resistance) able to regulate this molecule display the specific interaction effect and experiment report are the same as above.