InterPAD - DETAILS

(1beta)-isomer of fangchinoline, 7-O-demethyl-tetrandrine, 7-O-demethyltetrandrine, berbaman-7-ol, 6,6',12-trimethoxy-2,2'-dimethyl-, (1beta)-, fangchinoline, isofangchinoline, limacine, thaligine, thalrugosine

No.	Title	Href
1	Activation of notch 3/c-MYC/CHOP axis regulates apoptosis and promotes sensitivity of lung cancer cells to mTOR inhibitor everolimus. Biochem Pharmacol. 2020 May;175:113921. doi: 10.1016/j.bcp.2020.113921.	`Click`

No.

Title

Href

Activation of notch 3/c-MYC/CHOP axis regulates apoptosis and promotes sensitivity of lung cancer cells to mTOR inhibitor everolimus. Biochem Pharmacol. 2020 May;175:113921. doi: 10.1016/j.bcp.2020.113921.

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Name	Fangchinoline
PubChem CID	73481
Molecular Weight	608.7g/mol
Synonyms	(1beta)-isomer of fangchinoline, 7-O-demethyl-tetrandrine, 7-O-demethyltetrandrine, berbaman-7-ol, 6,6',12-trimethoxy-2,2'-dimethyl-, (1beta)-, fangchinoline, isofangchinoline, limacine, thaligine, thalrugosine
Formula	C₃₇H₄₀N₂O₆
SMILES	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC
InChI	1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29-/m0/s1
InChIKey	IIQSJHUEZBTSAT-VMPREFPWSA-N
CAS Number	436-77-1
ChEMBL ID	CHEMBL504256
ChEBI ID	CHEBI:132893
Herb ID	HBIN026356
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	FenFangJi
Use Part	Stephania tetrandra S. Moore
Habitat	ZheJiang, AnHui, JiangXi, FuJian, GuangDong, GuangXi
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Menispermaceae 　　　　　-->Genus: Stephania 　　　　　　-->Species: Stephania tetrandra

Pair Name	Fangchinoline, Everolimus
Partner Name	Everolimus
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Expression	DDIT3	hsa1649
	Down-regulation	Phosphorylation	EIF4EBP1	hsa1978
	Up-regulation	Expression	HES1	hsa3280
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Expression	MYC	hsa4609
	Up-regulation	Expression	NOTCH1	hsa4851
	Up-regulation	Expression	NOTCH3	hsa4854
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
	NCI-H358	Minimally invasive lung adenocarcinoma	Homo sapiens (Human)	CVCL_1559
	HCC827	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_2063
	NCI-H1975	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_1511
Result	Firstly link CHOP to Notch 3/c-MYC axis-dependent apoptosis and provide the Notch 3/c-MYC/CHOP activation as a promising strategy for mTOR-targeted combination therapy in lung cancer treatment.