InterPAD - DETAILS

Coleonol, colforsin, Forskolin, N,N-dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester HCl, NKH 477, NKH-477, NKH477

No.	Title	Href
1	Forskolin affects proliferation, migration and Paclitaxel-mediated cytotoxicity in non-small-cell lung cancer cell lines via adenylyl cyclase/cAMP axis. Eur J Cell Biol. 2023 Jun;102(2):151292. doi: 10.1016/j.ejcb.2023.151292.	`Click`
2	Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment. Tumour Biol. 2016 Sep;37(9):12643-12654. doi: 10.1007/s13277-016-5179-7.	`Click`

No.

Title

Href

Forskolin affects proliferation, migration and Paclitaxel-mediated cytotoxicity in non-small-cell lung cancer cell lines via adenylyl cyclase/cAMP axis. Eur J Cell Biol. 2023 Jun;102(2):151292. doi: 10.1016/j.ejcb.2023.151292.

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Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment. Tumour Biol. 2016 Sep;37(9):12643-12654. doi: 10.1007/s13277-016-5179-7.

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Name	Forskolin
PubChem CID	47936
Molecular Weight	410.5g/mol
Synonyms	Coleonol, colforsin, Forskolin, N,N-dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester HCl, NKH 477, NKH-477, NKH477
Formula	C₂₂H₃₄O₇
SMILES	CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O
InChI	1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChIKey	OHCQJHSOBUTRHG-KGGHGJDLSA-N
CAS Number	66575-29-9
ChEMBL ID	CHEMBL52606
ChEBI ID	CHEBI:42471
Herb ID	HBIN026686
Drug Bank ID	DB02587
KEGG ID	C09076
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	MaoHouQiaoRuiHua
Use Part	Whole herb
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Plectranthus 　　　　　　-->Species: Plectranthus barbatus

Pair Name	Forskolin, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	CCNA1	hsa8900
	Up-regulation	Expression	CDH1	hsa999
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	PSMD9	hsa5715
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	Our findings encourage the design of future studies aimed at further exploring the Forskolin employment in NSCLC treatment.

Pair Name	Forskolin, Ponatinib
Partner Name	Ponatinib
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Gene Regulation	Down-regulation	Phosphorylation	CRKL	hsa1399
In Vitro Model	KCL-22	Chronic myelogenous leukemia, BCR-ABL1 positive	Homo sapiens (Human)	CVCL_2091
	K-562	Blast phase chronic myelogenous leukemia	Homo sapiens (Human)	CVCL_0004
	HH [Human lymphoma]	Primary cutaneous T-cell non-Hodgkin lymphoma	Homo sapiens (Human)	CVCL_1280
	HEK293	Healthy	Homo sapiens (Human)	CVCL_0045
	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
Result	This study provides new insight into the biological underpinnings of BCR-ABL-driven CML and potential rationale for investigating novel treatment strategies for patients with T315I CML.