| Name | Eurycomalactone | ||
| PubChem CID | 441793 | ||
| Molecular Weight | 348.4g/mol | ||
| Formula | C₁₉H₂₄O₆ | ||
| SMILES | CC1C2C(C3C4(C(CC(=O)C3(C1C(=O)O2)C)C(=CC(=O)C4O)C)C)O | ||
| InChI | 1S/C19H24O6/c1-7-5-10(20)16(23)18(3)9(7)6-11(21)19(4)12-8(2)14(25-17(12)24)13(22)15(18)19/h5,8-9,12-16,22-23H,6H2,1-4H3/t8-,9+,12-,13+,14-,15-,16-,18+,19+/m1/s1 | ||
| InChIKey | OGHYZHNTIINXEO-MGBQOKOWSA-N | ||
| CAS Number | 23062-24-0 | ||
| ChEMBL ID | CHEMBL1081239 | ||
| ChEBI ID | CHEBI:4944 | ||
| KEGG ID | C08759 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | DongGeALi | ||
| Use Part | Root | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Simaroubaceae
-->Genus: Eurycoma
-->Species: Eurycoma longifolia
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| Pair Name | Eurycomalactone, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Phosphorylation | NFKB1 | hsa4790 | |
| Up-regulation | Activity | PARP1 | hsa142 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | This finding provides a rationale for the combined use of chemotherapy drugs with ECL to improve their efficacy in NSCLC treatment. | |||
