isofuranodiene
| Name | Furanodiene | ||
| PubChem CID | 636458 | ||
| Molecular Weight | 216.32g/mol | ||
| Synonyms |
isofuranodiene |
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| Formula | C₁₅H₂₀O | ||
| SMILES | CC1=CCC2=C(CC(=CCC1)C)OC=C2C | ||
| InChI | 1S/C15H20O/c1-11-5-4-6-12(2)9-15-14(8-7-11)13(3)10-16-15/h6-7,10H,4-5,8-9H2,1-3H3/b11-7+,12-6+ | ||
| InChIKey | VMDXHYHOJPKFEK-IAVOFVOCSA-N | ||
| CAS Number | 57566-47-9 | ||
| ChEMBL ID | CHEMBL324514 | ||
| ChEBI ID | CHEBI:80824 | ||
| Herb ID | HBIN026855 | ||
| KEGG ID | C16959 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | MoYao | ||
| Use Part | Balsam | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Heart, Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Burseraceae
-->Genus: Commiphora
-->Species: Commiphora myrrha
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| Chineses Pinyin | EZhu | ||
| Use Part | Rhizome | ||
| Habitat | ZheJiang, JiangXi, FuJian, TaiWan, HuNan, GuangDong, GuangXi, SiChuan, YunNan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma phaeocaulis
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| Chineses Pinyin | GanJiang | ||
| Use Part | Rhizome | ||
| Habitat | China | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Stomach, Kidney, Heart, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Zingiber
-->Species: Zingiber officinale
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| Chineses Pinyin | YuJin | ||
| Use Part | Tuberoid | ||
| Habitat | JiangSu, ZheJiang, FuJian, GuangDong, GuangXi, JiangXi, SiChuan, YunNan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver, Heart, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma wenyujin
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| Chineses Pinyin | DangShen | ||
| Use Part | Root | ||
| Habitat | HuBei, HuNan, SiChuan, GuiZhou | ||
| Flavor | Sweet | ||
| Meridian Tropism | Spleen, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Campanulaceae
-->Genus: Codonopsis
-->Species: Codonopsis pilosula
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| Chineses Pinyin | BaiZhu | ||
| Use Part | Root | ||
| Habitat | AnHui, ZheJiang, JiangXi | ||
| Flavor | Bitter, Sweet | ||
| Meridian Tropism | Spleen, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Atractylodes
-->Species: Atractylodes macrocephala
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| Chineses Pinyin | YinXianCao | ||
| Use Part | Whole Herb, Root, Rhizome | ||
| Habitat | HeiLongJiang, JiLin, HeBei, ShanXi, ShanDong, Shaanxi, GanSu, North Korea, Japan | ||
| Flavor | Pungent, Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Chloranthales
-->Family: Chloranthaceae
-->Genus: Chloranthus
-->Species: Chloranthus japonicus
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| Chineses Pinyin | JiangHuang | ||
| Use Part | Tuberoid | ||
| Habitat | SiChuan, FuJian, GuangDong, ZheJiang, JiangXi | ||
| Flavor | Pungent; Bitter | ||
| Meridian Tropism | Spleen; Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma longa
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| Pair Name | Furanodiene, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | CTNNB1 | hsa1499 | |
| Down-regulation | Expression | ITGAV | hsa3685 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Down-regulation | Phosphorylation | PIK3R1 | hsa5295 | |
| Down-regulation | Phosphorylation | PTK2 | hsa5747 | |
| Down-regulation | Phosphorylation | PXN | hsa5829 | |
| Down-regulation | Phosphorylation | SRC | hsa6714 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| Result | These observations indicate that furanodiene is a potential agent that may be utilized to improve the anticancer efficacy of doxorubicin and overcome the risk of chemotherapy in highly metastatic breast cancer. | |||
| Pair Name | Furanodiene, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAD | hsa572 |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP7 | hsa840 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Down-regulation | Expression | ESR1 | hsa2099 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| Result | These results indicate that furanodiene may be a promising and safety natural agent for cancer adjuvant therapy in the future. | |||
| Pair Name | Furanodiene, Germacrone | |||
| Partner Name | Germacrone | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell proliferation | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 | |
| Result | Unpredictable and complex interactions among different components in Curcuma WenyujinY.H.Chenet C Ling may exist. The intra-herb interactions should be taken into consideration when attempts are made to interpret the art of TCM formulation or other similar recipes. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combined effects of furanodiene and doxorubicin on the migration and invasion of MDA-MB-231 breast cancer cells in vitro. Oncol Rep. 2017 Apr;37(4):2016-2024. doi: 10.3892/or.2017.5435. | Click |
| 2 | Furanodiene enhances the anti-cancer effects of doxorubicin on ERα-negative breast cancer cells in vitro. Eur J Pharmacol. 2016 Mar 5;774:10-9. doi: 10.1016/j.ejphar.2015.11.039. | Click |
| 3 | Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation. Cell J. 2013 Summer;15(2):160-5. | Click |
