InterPAD - DETAILS

34031-32-8, AURANOFIN, (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate, AUJRCFUBUPVWSZ-UHFFFAOYSA-M, BCP08217, MMV688978, SKF 39162, AKOS026750078, FT-0662343, D78135, A937040, 1-Thio-|A-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate, 1-Thio-beta-D-glucopyranosatotriethyl phosphine gold-2,3,4,6-tetraacetate, 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium, gold(1+) [3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]sulfanide triethylphosphine, gold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphane, SKF-39162; SKF-D-39162; SKF 39162; SKF D 39162; SKFD-39162; SKFD39162

No.	Title	Href
1	Menadione Potentiates Auranofin-Induced Glioblastoma Cell Death. Int J Mol Sci. 2022 Dec 11;23(24):15712. doi: 10.3390/ijms232415712.	`Click`
2	Morin enhances auranofin anticancer activity by up-regulation of DR4 and DR5 and modulation of Bcl-2 through reactive oxygen species generation in Hep3B human hepatocellular carcinoma cells. Phytother Res. 2019 May;33(5):1384-1393. doi: 10.1002/ptr.6329.	`Click`

No.

Title

Href

Menadione Potentiates Auranofin-Induced Glioblastoma Cell Death. Int J Mol Sci. 2022 Dec 11;23(24):15712. doi: 10.3390/ijms232415712.

Click

Morin enhances auranofin anticancer activity by up-regulation of DR4 and DR5 and modulation of Bcl-2 through reactive oxygen species generation in Hep3B human hepatocellular carcinoma cells. Phytother Res. 2019 May;33(5):1384-1393. doi: 10.1002/ptr.6329.

Click

Name	Auranofin
PubChem CID	24199313
Molecular Weight	678.5g/mol
Synonyms	34031-32-8, AURANOFIN, (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate, AUJRCFUBUPVWSZ-UHFFFAOYSA-M, BCP08217, MMV688978, SKF 39162, AKOS026750078, FT-0662343, D78135, A937040, 1-Thio-\|A-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate, 1-Thio-beta-D-glucopyranosatotriethyl phosphine gold-2,3,4,6-tetraacetate, 3,4,5-Triacetyloxy-6-(acetyloxymethyl) oxane-2-thiolate triethylphosphanium, gold(1+) [3,4,5-tris(acetyloxy)-6-[(acetyloxy)methyl]oxan-2-yl]sulfanide triethylphosphine, gold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphane, SKF-39162; SKF-D-39162; SKF 39162; SKF D 39162; SKFD-39162; SKFD39162
Drug Type	Small molecule
Formula	C₂₀H₃₄AuO₉PS
SMILES	CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]
InChI	1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1
InChIKey	AUJRCFUBUPVWSZ-UHFFFAOYSA-M
CAS Number	34031-32-8
TTD ID	D0L2UN
Drug Bank ID	DB00995
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Vitamin K3, Auranofin
Partner Name	Vitamin K3
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Induction-->ROS accumulation
Gene Regulation	Up-regulation	Expression	TXNRD1	hsa7296
In Vitro Model	T98G	Glioblastoma	Homo sapiens (Human)	CVCL_0556
	U-87MG ATCC	Glioblastoma	Homo sapiens (Human)	CVCL_0022
	LN-229	Glioblastoma	Homo sapiens (Human)	CVCL_0393
Result	Our results identify TrxR1 as an attractive drug target and highlights AF as an off-patent drug candidate in GBM therapy.

Pair Name	Morin, Auranofin
Partner Name	Morin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->ROS generation
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BIRC2	hsa329
	Down-regulation	Expression	BIRC3	hsa330
	Down-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CASP8	hsa841
	Down-regulation	Expression	CASP9	hsa842
	Up-regulation	Expression	CYCS	hsa54205
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	TNFRSF10A	hsa8797
	Up-regulation	Expression	TNFRSF10B	hsa8795
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
Result	This study provides evidence that morin can enhance the anticancer activity of AF in Hep3B human hepatocellular carcinoma cells, indicating that its combination could be an alternative treatment strategy for the hepatocellular carcinoma.