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barbaloin, barbaloin, (S)-isomer, barbaloin, beta-D-isomer, barbaloin, monoglucoside, isobarbaloin

No.	Title	Href
1	Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokinesAloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines. Cancer Chemother Pharmacol. 2020 Sep;86(3):419-426. doi: 10.1007/s00280-020-04125-w.	`Click`
2	Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway. Cancer Med. 2020 Feb;9(3):1141-1151. doi: 10.1002/cam4.2723.	`Click`
3	Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. Amino Acids. 2013 Jan;44(1):293-300. doi: 10.1007/s00726-011-1166-x.	`Click`
4	Aloin and CPT-11 combination activates miRNA-133b and downregulates IGF1R- PI3K/AKT/mTOR and MEK/ERK pathways to inhibit colorectal cancer progression. Biomed Pharmacother. 2023 Dec 31;169:115911. doi: 10.1016/j.biopha.2023.115911.	`Click`

No.

Title

Href

Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokinesAloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines. Cancer Chemother Pharmacol. 2020 Sep;86(3):419-426. doi: 10.1007/s00280-020-04125-w.

Click

Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway. Cancer Med. 2020 Feb;9(3):1141-1151. doi: 10.1002/cam4.2723.

Click

Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. Amino Acids. 2013 Jan;44(1):293-300. doi: 10.1007/s00726-011-1166-x.

Click

Aloin and CPT-11 combination activates miRNA-133b and downregulates IGF1R- PI3K/AKT/mTOR and MEK/ERK pathways to inhibit colorectal cancer progression. Biomed Pharmacother. 2023 Dec 31;169:115911. doi: 10.1016/j.biopha.2023.115911.

Click

Name	Aloin
PubChem CID	12305761
Molecular Weight	418.4g/mol
Synonyms	barbaloin, barbaloin, (S)-isomer, barbaloin, beta-D-isomer, barbaloin, monoglucoside, isobarbaloin
Formula	C₂₁H₂₂O₉
SMILES	C1=CC2=C(C(=C1)O)C(=O)C3=C(C2C4C(C(C(C(O4)CO)O)O)O)C=C(C=C3O)CO
InChI	1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14+,17-,19+,20-,21+/m1/s1
InChIKey	AFHJQYHRLPMKHU-OSYMLPPYSA-N
CAS Number	1415-73-2
ChEMBL ID	CHEMBL2103763
ChEBI ID	CHEBI:2991
Herb ID	HBIN015313
KEGG ID	C10305
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	LuHui
Use Part	Solid Residue Obtained By Evaporating Liquid Which Drains From Leaves
Habitat	Egypt , South Africa , Kenya, Nigeria , India
Flavor	Bitter
Meridian Tropism	Liver, Stomach, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Asphodelaceae 　　　　　-->Genus: Aloe 　　　　　　-->Species: Aloe barbadensis

Chineses Pinyin	BanWenLuHui
Use Part	Solid Residue Obtained By Evaporating Liquid Which Drains From Leaves
Habitat	India , America , Egypt , South Africa , Kenya, Nigeria
Flavor	Bitter
Meridian Tropism	Large intestine, Stomach, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Asphodelaceae 　　　　　-->Genus: Aloe 　　　　　　-->Species: Aloe barbadensis

Chineses Pinyin	HaoWangJiaoLuHui
Use Part	Solid Residue Obtained By Evaporating Liquid Which Drains From Leaves
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Asphodelaceae 　　　　　-->Genus: Aloe 　　　　　　-->Species: Aloe ferox

Pair Name	Aloin, Metformin
Partner Name	Metformin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Up-regulation	Activity	AKT1	hsa207
	Up-regulation	Activity	MTOR	hsa2475
	Up-regulation	Activity	PIK3CA	hsa5290
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
In Vitro Model	BEL-7402	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_5492
In Vivo Model	For xenograft study, mice were inoculated subcutaneously into the right-back with 7.5×10⁶ HepG2 cells in 200 μl PBS and Matrigel (1:1).
Result	Our research demonstrated that the concomitant treatment with aloin and MET enhances the antitumor effect by inhibiting the growth and invasion as well as inducing apoptosis and autophagy in HCC through PI3K/AKT/mTOR pathway.

Pair Name	Aloin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Gene Regulation	Up-regulation	Expression	TG2	hsa7052
Gene Regulation	Up-regulation	Expression	TYR	hsa7299
In Vitro Model	B16-F10	Mouse melanoma	Mus musculus (Mouse)	CVCL_0159
Result	The results suggest that aloin possesses antineoplastic and antimetastatic properties, exerted likely through the induction of melanoma cell differentiation.

Pair Name	Aloin, Irinotecan
Partner Name	Irinotecan
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	IGF1R	hsa3480
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
In Vitro Model	LoVo	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0399
In Vivo Model	4×10⁶ LoVo cells were suspended in serum-free Matrigel medium.Control (DMSO), CPT-11(2 mg/Kg), Aloin (20 mg/Kg), and combination (2 mg/Kg CPT-11 + 20 mg/Kg Aloin). The mice were treated via intratumor injection, every 48 h for four weeks.
Result	Our findings suggests that CPT-11 and Aloin are potential combination treatment partners against colorectal cancer. MicroRNA-133b may serve as a co-therapeutic target with IGF1R against colorectal cancer, which might overcome the existing treatment limitations.

Pair Name	Aloin, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Biological Phenomena	Induction-->Oxidative Stress
Gene Regulation	Down-regulation	Expression	IL19	hsa29949
	Down-regulation	Expression	IL1B	hsa3553
	Down-regulation	Expression	IL6	hsa3569
	Down-regulation	Expression	TNF	hsa7124
In Vivo Model	Male Wistar rats (150-200 g, age 6-8 weeks) were used in this study.
Result	Our results highlight the necessity to further investigate the chemopreventive effects of aloin against other chemotherapeutic agents.