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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Chrysin
PubChem CID 5281607
Molecular Weight 254.24g/mol
Synonyms

5,7-dihydroxy-flavone, 5,7-dihydroxyflavone, chrysin, chrysine
Formula C₁₅H₁₀O₄
SMILES C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O
InChI 1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
InChIKey RTIXKCRFFJGDFG-UHFFFAOYSA-N
CAS Number 480-40-0
ChEMBL ID CHEMBL117
ChEBI ID CHEBI:75095
Herb ID HBIN020447
Drug Bank ID DB15581
KEGG ID C10028
Toxicity Organism Test Type Route(Dose)
rat LD50 intraperitoneal(165 mg/kg)
mouse LD50 intraperitoneal(254 mg/kg)
rat LD50 oral(322 mg/kg)
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
(1) Scutellaria amoena Cold
Chineses Pinyin DianHuangQin
Use Part Root
Habitat SiChuan, YunNan
Flavor Bitter
Meridian Tropism Lung, Heart, Liver, Gallbladder, Large intestine
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Lamiales
　　　　-->Family: Lamiaceae
　　　　　-->Genus: Scutellaria
　　　　　　-->Species: Scutellaria amoena
(2) Oroxylum indicum Cool
Chineses Pinyin MuHuDie
Use Part Seed
Habitat YunNan, GuiZhou
Flavor Lung; Liver; Stomach
Meridian Tropism Bitter; Sweet
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Lamiales
　　　　-->Family: Bignoniaceae
　　　　　-->Genus: Oroxylum
　　　　　　-->Species: Oroxylum indicum
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 103
Ref_2
Pair Name Chrysin, Metformin
Partner Name Metformin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Gene Regulation Down-regulation Expression CCND1 hsa595
Down-regulation Expression TERT hsa7015
In Vitro Model T-47D Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0553
Result The conmbination of metformin and chrysin suppressing hTERT and cyclin D1 gene expression might offer an appropriate approach for breast cancer therapy.
Combination Pair ID: 104
Ref_3
Pair Name Chrysin, Cisplatin
Partner Name Cisplatin
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Gene Regulation Down-regulation Expression CASP3 hsa836
Up-regulation Activity CASP8 hsa841
Down-regulation Expression CFLAR hsa8837
Down-regulation Cleavage PARP1 hsa142
In Vitro Model Hep-G2 Hepatoblastoma Homo sapiens (Human) CVCL_0027
Result The combination of Chrysin and Cisplatin Induces Apoptosis in HepG2 through Down-regulation of cFLIP and Activity of Caspase.
Combination Pair ID: 655
Ref_4
Pair Name Chrysin, Cisplatin
Partner Name Cisplatin
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Gene Regulation Up-regulation Expression / KEGG ID N.A.
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP8 hsa841
Up-regulation Cleavage CASP9 hsa842
Up-regulation Expression MAPK3 hsa5595
Up-regulation Expression PARP1 hsa142
Up-regulation Expression TNFRSF10B hsa8795
Up-regulation Expression TP53 hsa7157
In Vitro Model Hep-G2 Hepatoblastoma Homo sapiens (Human) CVCL_0027
Result Our results suggest that combination of chrysin and cisplatin is a promising strategy for chemotherapy of human cancers that are resistant to cisplatin.
Combination Pair ID: 656
Ref_5
Pair Name Chrysin, Cisplatin
Partner Name Cisplatin
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
Biological Phenomena Induction-->Apoptosis
In Vitro Model U-87MG ATCC Glioblastoma Homo sapiens (Human) CVCL_0022
Result Chrysin additively potentiates the antiproliferative, cell cycle arrest and apoptotic activity of cisplatin in human glioma cancer (U87) cells.
Drug(s) whose resistance can be reversed by this phytochemical
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Combination Pair ID: 105
Ref_6
Pair Name Chrysin, Fluorouracil
Partner Name Fluorouracil
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Up-regulation Expression BAX hsa581
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Down-regulation Expression CCNB1 hsa891
Up-regulation Expression CCND1 hsa595
Down-regulation Expression CDK1 hsa983
Up-regulation Expression CDK6 hsa1021
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression TP53 hsa7157
In Vitro Model AGS Gastric adenocarcinoma Homo sapiens (Human) CVCL_0139
Result Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells
Drug(s) whose toxicity can be decreased by this phytochemical
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Combination Pair ID: 997
Ref_1
Pair Name Chrysin, Paclitaxel
Partner Name Paclitaxel
Disease Info [ICD-11: 2A00-2F9Z] Solid tumour or cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression CASP3 hsa836
Down-regulation Expression CAT hsa847
Up-regulation Expression COX2 hsa4513
Down-regulation Expression GPX3 hsa2878
Down-regulation Expression GSTK1 hsa373156
Up-regulation Expression HAVCR1 hsa26762
Up-regulation Expression NFKB1 hsa4790
Down-regulation Expression SOD1 hsa6647
In Vivo Model Thirty-five male Sprague-Dawley rats were divided into five groups (n = 7): Group I (normal control), Group II (CR alone at a dose of 50 mg/kg), Group III (Pax at a dose of 2 mg/kg), Group IV (Pax+CR 25), and Group V (Pax+CR 50).
Result CR exhibited the ability to reduce oxidative DNA damage, exert anti-apoptotic and anti-inflammatory properties, and mitigate the toxic effects of Pax-induced hepatorenal toxicity.
04. Reference
No. Title Href
1 Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis. Life Sci. 2023 Nov 1;332:122096. doi: 10.1016/j.lfs.2023.122096. Click
2 Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression. Asian Pac J Cancer Prev. 2018 Apr 25;19(4):977-982. doi: 10.22034/APJCP.2018.19.4.977. Click
3 The Combination of Chrysin and Cisplatin Induces Apoptosis in HepG2 through Down-regulation of cFLIP and Activity of Caspase. Anticancer Agents Med Chem. 2023;23(4):432-439. doi: 10.2174/1871520622666220615121525. Click
4 Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53. Chem Biol Interact. 2015 May 5;232:12-20. doi: 10.1016/j.cbi.2015.03.003. Click
5 Additive anticancer effects of chrysin and low dose cisplatin in human malignant glioma cell (U87) proliferation and evaluation of the mechanistic pathway. J BUON. 2015 Sep-Oct;20(5):1327-36. Click
6 Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells. Oncol Lett. 2021 Jan;21(1):24. doi: 10.3892/ol.2020.12285. Click
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