1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, helichrysetin
Name | Helichrysetin | ||
PubChem CID | 6253344 | ||
Molecular Weight | 286.28g/mol | ||
Synonyms |
1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, helichrysetin |
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Formula | C₁₆H₁₄O₅ | ||
SMILES | COC1=CC(=CC(=C1C(=O)C=CC2=CC=C(C=C2)O)O)O | ||
InChI | 1S/C16H14O5/c1-21-15-9-12(18)8-14(20)16(15)13(19)7-4-10-2-5-11(17)6-3-10/h2-9,17-18,20H,1H3/b7-4+ | ||
InChIKey | OWGUBYRKZATRIT-QPJJXVBHSA-N | ||
CAS Number | 62014-87-3 | ||
ChEMBL ID | CHEMBL507998 | ||
ChEBI ID | CHEBI:178332 | ||
Herb ID | HBIN028945 | ||
Structure |
Download
2D
MOL
3D
MOL
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Chineses Pinyin | YunNanCaoKou | ||
Use Part | Fruit | ||
Habitat | YunNan |
Chineses Pinyin | GaoLiangJiang | ||
Use Part | Rhizome | ||
Habitat | HaiNan, GuangXi, YunNan, TaiWan, GuangDong | ||
Flavor | Pungent | ||
Meridian Tropism | Spleen; Stomach | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Alpinia
-->Species: Alpinia officinarum
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Pair Name | Helichrysetin, Tumor necrosis factor-alpha | |||
Partner Name | Tumor necrosis factor-alpha | |||
Disease Info | [ICD-11: 2F7Z] | Glioma | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
Down-regulation | Phosphorylation | CHUK | hsa1147 | |
Down-regulation | Phosphorylation | EGFR | hsa1956 | |
Down-regulation | Phosphorylation | NR2C2 | hsa7182 | |
Up-regulation | Activity | PARP1 | hsa142 | |
Down-regulation | Phosphorylation | RELA | hsa5970 | |
In Vitro Model | HeLa | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0030 |
T98G | Glioblastoma | Homo sapiens (Human) | CVCL_0556 | |
Result | Helichrysetin and TNF‑α synergistically promoted apoptosis by inhibiting TAK1/IKK/NF‑κB and TAK1/EGFR signaling pathways in HeLa and T98G cells, indicating a potential therapeutic strategy for cancer. |