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1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, helichrysetin

No.	Title	Href
1	Helichrysetin and TNF‑α synergistically promote apoptosis by inhibiting overactivation of the NF‑κB and EGFR signaling pathways in HeLa and T98G cells. Int J Mol Med. 2021 Apr;47(4):49. doi: 10.3892/ijmm.2021.4882.	`Click`

No.

Title

Href

Helichrysetin and TNF‑α synergistically promote apoptosis by inhibiting overactivation of the NF‑κB and EGFR signaling pathways in HeLa and T98G cells. Int J Mol Med. 2021 Apr;47(4):49. doi: 10.3892/ijmm.2021.4882.

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Name	Helichrysetin
PubChem CID	6253344
Molecular Weight	286.28g/mol
Synonyms	1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, helichrysetin
Formula	C₁₆H₁₄O₅
SMILES	COC1=CC(=CC(=C1C(=O)C=CC2=CC=C(C=C2)O)O)O
InChI	1S/C16H14O5/c1-21-15-9-12(18)8-14(20)16(15)13(19)7-4-10-2-5-11(17)6-3-10/h2-9,17-18,20H,1H3/b7-4+
InChIKey	OWGUBYRKZATRIT-QPJJXVBHSA-N
CAS Number	62014-87-3
ChEMBL ID	CHEMBL507998
ChEBI ID	CHEBI:178332
Herb ID	HBIN028945
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	YunNanCaoKou
Use Part	Fruit
Habitat	YunNan

Chineses Pinyin	GaoLiangJiang
Use Part	Rhizome
Habitat	HaiNan, GuangXi, YunNan, TaiWan, GuangDong
Flavor	Pungent
Meridian Tropism	Spleen; Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Zingiberales 　　　　-->Family: Zingiberaceae 　　　　　-->Genus: Alpinia 　　　　　　-->Species: Alpinia officinarum

Pair Name	Helichrysetin, Tumor necrosis factor-alpha
Partner Name	Tumor necrosis factor-alpha
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Activity	CASP3	hsa836
	Down-regulation	Phosphorylation	CHUK	hsa1147
	Down-regulation	Phosphorylation	EGFR	hsa1956
	Down-regulation	Phosphorylation	NR2C2	hsa7182
	Up-regulation	Activity	PARP1	hsa142
	Down-regulation	Phosphorylation	RELA	hsa5970
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
In Vitro Model	T98G	Glioblastoma	Homo sapiens (Human)	CVCL_0556
Result	Helichrysetin and TNF‑α synergistically promoted apoptosis by inhibiting TAK1/IKK/NF‑κB and TAK1/EGFR signaling pathways in HeLa and T98G cells, indicating a potential therapeutic strategy for cancer.