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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Helichrysetin
PubChem CID 6253344
Molecular Weight 286.28g/mol
Synonyms

1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, helichrysetin

Formula C₁₆H₁₄O₅
SMILES COC1=CC(=CC(=C1C(=O)C=CC2=CC=C(C=C2)O)O)O
InChI 1S/C16H14O5/c1-21-15-9-12(18)8-14(20)16(15)13(19)7-4-10-2-5-11(17)6-3-10/h2-9,17-18,20H,1H3/b7-4+
InChIKey OWGUBYRKZATRIT-QPJJXVBHSA-N
CAS Number 62014-87-3
ChEMBL ID CHEMBL507998
ChEBI ID CHEBI:178332
Herb ID HBIN028945
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
(1) Alpinia blepharocalyx Unknown
Chineses Pinyin YunNanCaoKou
Use Part Fruit
Habitat YunNan
(2) Alpinia officinarum Hot
Chineses Pinyin GaoLiangJiang
Use Part Rhizome
Habitat HaiNan, GuangXi, YunNan, TaiWan, GuangDong
Flavor Pungent
Meridian Tropism Spleen; Stomach
Species
>Kingdom: Viridiplantae
 -->Phylum: Streptophyta
  -->Class: Equisetopsida
   -->Order: Zingiberales
    -->Family: Zingiberaceae
     -->Genus: Alpinia
      -->Species: Alpinia officinarum
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 145
Pair Name Helichrysetin, Tumor necrosis factor-alpha
Partner Name Tumor necrosis factor-alpha
Disease Info [ICD-11: 2F7Z] Glioma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Activity CASP3 hsa836
Down-regulation Phosphorylation CHUK hsa1147
Down-regulation Phosphorylation EGFR hsa1956
Down-regulation Phosphorylation NR2C2 hsa7182
Up-regulation Activity PARP1 hsa142
Down-regulation Phosphorylation RELA hsa5970
In Vitro Model HeLa Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0030
T98G Glioblastoma Homo sapiens (Human) CVCL_0556
Result Helichrysetin and TNF‑α synergistically promoted apoptosis by inhibiting TAK1/IKK/NF‑κB and TAK1/EGFR signaling pathways in HeLa and T98G cells, indicating a potential therapeutic strategy for cancer.
04. Reference
No. Title Href
1 Helichrysetin and TNF‑α synergistically promote apoptosis by inhibiting overactivation of the NF‑κB and EGFR signaling pathways in HeLa and T98G cells. Int J Mol Med. 2021 Apr;47(4):49. doi: 10.3892/ijmm.2021.4882. Click
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