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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Periplocin
PubChem CID 14463159
Molecular Weight 696.8g/mol
Synonyms

periplocin
Formula C₃₆H₅₆O₁₃
SMILES CC1C(C(CC(O1)OC2CCC3(C4CCC5(C(CCC5(C4CCC3(C2)O)O)C6=CC(=O)OC6)C)C)OC)OC7C(C(C(C(O7)CO)O)O)O
InChI 1S/C36H56O13/c1-18-31(49-32-30(41)29(40)28(39)25(16-37)48-32)24(44-4)14-27(46-18)47-20-5-9-33(2)22-6-10-34(3)21(19-13-26(38)45-17-19)8-12-36(34,43)23(22)7-11-35(33,42)15-20/h13,18,20-25,27-32,37,39-43H,5-12,14-17H2,1-4H3/t18-,20+,21-,22+,23-,24+,25-,27+,28-,29+,30-,31-,32+,33-,34-,35+,36+/m1/s1
InChIKey KWBPKUMWVXUSCA-AXQDKOMKSA-N
CAS Number 13137-64-9
Herb ID HBIN039256
Toxicity Organism Test Type Route(Dose)
rat LD50 intraperitoneal(165 mg/kg)
mouse LD50 intraperitoneal(254 mg/kg)
rat LD50 oral(322 mg/kg)
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
(1) Perilla frutescens Warm
Chineses Pinyin ZiSuGeng
Use Part Stem
Habitat HuBei, JiangSu, HeNan, SiChuan, GuangXi, ShanDong, GuangDong, ZheJiang, HeBei, ShanXi
Flavor Pungent
Meridian Tropism Lung, Spleen
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Lamiales
　　　　-->Family: Lamiaceae
　　　　　-->Genus: Perilla
　　　　　　-->Species: Perilla frutescens
(2) Periploca sepium Warm
Chineses Pinyin XiangJiaPi
Use Part Root Bark
Habitat JiLin, LiaoNing, NeiMengGu, HeBei, ShanXi, HeNan, Shaanxi, GanSu, NingXia, SiChuan, ShanDong, JiangSu
Flavor Pungent, Bitter
Meridian Tropism Liver, Kidney, Heart
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Gentianales
　　　　-->Family: Apocynaceae
　　　　　-->Genus: Periploca
　　　　　　-->Species: Periploca sepium
(3) Citrus reticulata Warm
Chineses Pinyin JuPi
Use Part Pericarp
Habitat ZheJiang, JiangXi, FuJian, TaiWan, HuBei, GuangDong, HaiNan, GuangXi, SiChuan
Flavor Pungent, Bitter
Meridian Tropism Spleen, Stomach, Lung
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Sapindales
　　　　-->Family: Rutaceae
　　　　　-->Genus: Citrus
　　　　　　-->Species: Citrus reticulata
(4) Perilla frutescens Warm
Chineses Pinyin HuiHuiSuGeng
Use Part Stem
Habitat JiangSu, HeNan, ZheJiang
Flavor Pungent
Meridian Tropism Spleen, Stomach, Lung
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Lamiales
　　　　-->Family: Lamiaceae
　　　　　-->Genus: Perilla
　　　　　　-->Species: Perilla frutescens
(5) Murraya paniculata Warm
Chineses Pinyin JiuLiXiangGen
Use Part Root
Habitat FuJian, GuangDong, GuangXi, YunNan, HuNan, HaiNan, GuiZhou, TaiWan
Flavor Pungent, Bitter
Meridian Tropism Heart, Liver, Lung
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Sapindales
　　　　-->Family: Rutaceae
　　　　　-->Genus: Murraya
　　　　　　-->Species: Murraya paniculata
(6) Strophanthuk kombe Unknown
Chineses Pinyin KangPiDuMaoXuanHua
Habitat GuangDong, GuangXi, YunNan
(7) Periploca sepium Unknown
Chineses Pinyin XiLaGangLiu
Use Part Root Cortex
Habitat Shaanxi, GanSu, QingHai, NingXia, XinJiang, HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, HeNan, SiChuan, JiangSu
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Gentianales
　　　　-->Family: Apocynaceae
　　　　　-->Genus: Periploca
　　　　　　-->Species: Periploca sepium
(8) Periploca forrestii Cool
Chineses Pinyin HeiLongGu
Use Part Root or whole herb
Flavor Bitter
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Gentianales
　　　　-->Family: Asclepiadaceae
　　　　　-->Genus: Periploca
　　　　　　-->Species: Periploca forrestii
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 611
Ref_1
Pair Name Periplocin, TNF-related apoptosis inducing ligand
Partner Name TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression BID hsa637
Up-regulation Cleavage CASP3 hsa836
Up-regulation Expression CASP8 hsa841
Up-regulation Expression EGR1 hsa1958
Up-regulation Phosphorylation MAPK1 hsa5594
Down-regulation Expression MCL1 hsa4170
Up-regulation Expression TNFRSF10A hsa8797
Up-regulation Expression TNFRSF10B hsa8795
In Vivo Model The proceduresusing animals were approved by the Animal Care and Use Committee.SGC-7901 cells (1×10⁵/100μL/mouse) were suspended in 0.9%physiological saline and subcutaneously injected into the right flank ofeach mouse.
Result Antitumor Effect of Periplocin in TRAIL-Resistant gastric cancer cells via upregulation of death receptor through activating ERK1/2-EGR1 pathway
Combination Pair ID: 959
Ref_2
Pair Name Periplocin, Gemcitabine
Partner Name Gemcitabine
Disease Info [ICD-11: 2C10] Pancreatic cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Down-regulation Expression BCL-xL hsa598
Down-regulation Expression BIRC5 hsa332
Up-regulation Cleavage CASP8 hsa841
Down-regulation Expression CCND1 hsa595
Down-regulation Expression CDK2 hsa1017
Down-regulation Expression CDK4 hsa1019
Down-regulation Expression CDK6 hsa1021
Down-regulation Expression FOS hsa2353
Down-regulation Expression HMOX1 hsa3162
Up-regulation Expression KEAP1 hsa9817
Down-regulation Expression NFE2L2 hsa4780
Up-regulation Cleavage PARP1 hsa142
Down-regulation Expression PRDX1 hsa5052
Down-regulation Phosphorylation RELA hsa5970
In Vitro Model PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0480
HEK293 Healthy Homo sapiens (Human) CVCL_0045
In Vivo Model PANC-1 and PANC-GR cell suspension (4×10⁶ cells per mouse mix with Matrigel 1:1) was subcutaneously injected into the right flank of mice and tumors were maintained until tumor volume reached 80 mm3.
Result Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells
Combination Pair ID: 960
Ref_3
Pair Name Periplocin, TNF-related apoptosis inducing ligand
Partner Name TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2B70.1] Esophageal squamous cell carcinoma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BIRC5 hsa332
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP8 hsa841
Down-regulation Activity CTNNB1 hsa1499
Down-regulation Phosphorylation CTNNB1 hsa1499
Down-regulation Activity FOXP3 hsa50943
Up-regulation Expression TNFRSF10A hsa8797
Up-regulation Expression TNFRSF10B hsa8795
In Vitro Model Eca-109 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_6898
TE-1 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_1759
YES-2 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_E322
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_1351
KYSE-410 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_1352
KYSE-510 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_1354
Result Our data suggest that CPP and TRAIL could be further explored as potential therapeutic approach for esophageal cancer.
04. Reference
No. Title Href
1 Antitumor Effect of Periplocin in TRAIL-Resistant gastric cancer cells via upregulation of death receptor through activating ERK1/2-EGR1 pathway. Mol Carcinog. 2019 Jun;58(6):1033-1045. doi: 10.1002/mc.22991. Click
2 Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells. Biomed Pharmacother. 2023 Jan;157:114039. doi: 10.1016/j.biopha.2022.114039. Click
3 Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy. J Exp Clin Cancer Res. 2019 Dec 21;38(1):501. doi: 10.1186/s13046-019-1498-z. Click
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