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7-hydroxyflavanone 4'-O-glucoside, likviritin, Likviriton, liquiritin, liquiritoside

No.	Title	Href
1	Combining TRAIL and liquiritin exerts synergistic effects against human gastric cancer cells and xenograft in nude mice through potentiating apoptosis and ROS generation. Biomed Pharmacother. 2017 Sep;93:948-960. doi: 10.1016/j.biopha.2017.06.095.	`Click`
2	Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. Int J Oncol. 2017 Nov;51(5):1383-1394. doi: 10.3892/ijo.2017.4134.	`Click`

No.

Title

Href

Combining TRAIL and liquiritin exerts synergistic effects against human gastric cancer cells and xenograft in nude mice through potentiating apoptosis and ROS generation. Biomed Pharmacother. 2017 Sep;93:948-960. doi: 10.1016/j.biopha.2017.06.095.

Click

Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. Int J Oncol. 2017 Nov;51(5):1383-1394. doi: 10.3892/ijo.2017.4134.

Click

Name	Liquiritin
PubChem CID	503737
Molecular Weight	418.4g/mol
Synonyms	7-hydroxyflavanone 4'-O-glucoside, likviritin, Likviriton, liquiritin, liquiritoside
Formula	C₂₁H₂₂O₉
SMILES	C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O
InChI	1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1
InChIKey	DEMKZLAVQYISIA-ZRWXNEIDSA-N
CAS Number	551-15-5
ChEMBL ID	CHEMBL511995
ChEBI ID	CHEBI:80845
Herb ID	HBIN033383
KEGG ID	C16989
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	GanCao
Use Part	Root, Rhizome
Habitat	HeiLongJiang, JiLin, LiaoNing, NeiMengGu, GanSu, XinJiang
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza uralensis

Chineses Pinyin	CuMaoGanCao
Use Part	Root, Rhizome
Habitat	NeiMengGu, Shaanxi, GanSu, QingHai, XinJiang
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza aspera

Chineses Pinyin	GuangGuoGanCao
Use Part	Root, Rhizome
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, NingXia, XinJiang
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach

Chineses Pinyin	HuangGanCao
Use Part	Root, Rhizome
Habitat	XinJiang, NeiMengGu, NingXia, GanSu, ShanXi
Flavor	Sweet
Meridian Tropism	Heart, Lung, Stomach, Spleen

Pair Name	Liquiritin, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->ROS generation
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	CASP9	hsa842
	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CDH2	hsa1000
	Up-regulation	Expression	FADD	hsa8772
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	TNFRSF10A	hsa8797
	Up-regulation	Expression	TNFRSF10B	hsa8795
	Down-regulation	Expression	TWIST1	hsa7291
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	AGS	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0139
In Vitro Model	SNU-216	Gastric tubular adenocarcinoma	Homo sapiens (Human)	CVCL_3946
Result	Combining TRAIL and liquiritin exerts synergistic effects against human gastric cancer cells and xenograft in nude mice through potentiating apoptosis and ROS generation

Pair Name	Liquiritin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Up-regulation	Expression	BECN1	hsa8678
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CCNA2	hsa890
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CDK4	hsa1019
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
In Vivo Model	5-week-old male BALB/c-nu mice, weighed 15–18 g, were subcutaneously injected with 2×10⁵ SGC7901/DDP cells in the left flank.
Result	Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo