InterPAD - DETAILS

3'-hydroxyresveratol, 3,3',4',5-tetrahydroxystilbene, 3,3',4,5'-tetrahydroxy stilbene, 3,3',4,5'-tetrahydroxystilbene, 3,5,3',4'-tetrahydroxy-stilbene, 3,5,3',4'-tetrahydroxy-trans-stilbene, 3,5,3',4'-tetrahydroxystilbene, astringinin, demethyl isorhapontigenin, piceatannol, piceatanol, RSVL-1

No.	Title	Href
1	Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer. Sci China Life Sci. 2023 Feb;66(2):298-312. doi: 10.1007/s11427-022-2185-9.	`Click`
2	Piceatannol Enhances the Antitumor Efficacy of Gemcitabine in Human A549 Non-Small Cell Lung Cancer Cells. Oncol Res. 2014;22(4):213-217. doi: 10.3727/096504015X14386062091398.	`Click`
3	The PKM2 inhibitor shikonin enhances piceatannol-induced apoptosis of glyoxalase I-dependent cancer cells. Genes Cells. 2024 Jan;29(1):52-62. doi: 10.1111/gtc.13084.	`Click`

No.

Title

Href

Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer. Sci China Life Sci. 2023 Feb;66(2):298-312. doi: 10.1007/s11427-022-2185-9.

Click

Piceatannol Enhances the Antitumor Efficacy of Gemcitabine in Human A549 Non-Small Cell Lung Cancer Cells. Oncol Res. 2014;22(4):213-217. doi: 10.3727/096504015X14386062091398.

Click

The PKM2 inhibitor shikonin enhances piceatannol-induced apoptosis of glyoxalase I-dependent cancer cells. Genes Cells. 2024 Jan;29(1):52-62. doi: 10.1111/gtc.13084.

Click

Name	Piceatannol
PubChem CID	667639
Molecular Weight	244.24g/mol
Synonyms	3'-hydroxyresveratol, 3,3',4',5-tetrahydroxystilbene, 3,3',4,5'-tetrahydroxy stilbene, 3,3',4,5'-tetrahydroxystilbene, 3,5,3',4'-tetrahydroxy-stilbene, 3,5,3',4'-tetrahydroxy-trans-stilbene, 3,5,3',4'-tetrahydroxystilbene, astringinin, demethyl isorhapontigenin, piceatannol, piceatanol, RSVL-1
Formula	C₁₄H₁₂O₄
SMILES	C1=CC(=C(C=C1C=CC2=CC(=CC(=C2)O)O)O)O
InChI	1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
InChIKey	CDRPUGZCRXZLFL-OWOJBTEDSA-N
CAS Number	10083-24-6
ChEMBL ID	CHEMBL69863
ChEBI ID	CHEBI:28814
Herb ID	HBIN039816
Drug Bank ID	DB08399
KEGG ID	C05901
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	HuZhang
Use Part	Rhizome
Habitat	Shaanxi, GanSu, JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuBei, HuNan, SiChuan
Flavor	Mildly bitter
Meridian Tropism	Liver, Gallbladder, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Caryophyllales 　　　　-->Family: Polygonaceae 　　　　　-->Genus: Polygonum 　　　　　　-->Species: Polygonum cuspidatum

Chineses Pinyin	TaoJinNiang
Use Part	Fruit
Habitat	FuJian, TaiWan, HuNan, GuangDong, HaiNan, GuangXi, GuiZhou, YunNan
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Myrtales 　　　　-->Family: Myrtaceae 　　　　　-->Genus: Rhodomyrtus 　　　　　　-->Species: Rhodomyrtus tomentosa

Pair Name	Piceatannol, Everolimus
Partner Name	Everolimus
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Phosphorylation	BECN1	hsa8678
	Down-regulation	Expression	SQSTM1	hsa8878
In Vitro Model	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
In Vivo Model	2×10⁶ SGC7901 cells were resuspended in phosphate-buffered saline (PBS) containing 50% Matrigel and engrafted subcutaneously into each flank of the mice.
Result	The findings of this study strongly support the application of combinatorial piceatannol and everolimus therapy in future clinical trials for gastric cancer patients.

Pair Name	Piceatannol, Gemcitabine
Partner Name	Gemcitabine
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAK1	hsa578
Gene Regulation	Up-regulation	Expression	BID	hsa637
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	The findings from this study show that piceatannol can enhance the cytotoxic effects of gemcitabine by enhancing expression of the proapoptotic protein Bak, thereby providing the rational basis for a novel combination strategy for the treatment of NSCLC.

Pair Name	Piceatannol, Shikonin
Partner Name	Shikonin
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	HL-60	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_0002
In Vitro Model	NCI-H522	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_1567
Result	These results indicate that concomitant use of low-dose shikonin potentiates piceatannol-induced apoptosis of GLO I-dependent cancer cells by augmenting methylglyoxal accumulation.