oxymatrine
Name | Oxymatrine | ||
PubChem CID | 114850 | ||
Molecular Weight | 264.36g/mol | ||
Synonyms |
oxymatrine |
||
Formula | C₁₅H₂₄N₂O₂ | ||
SMILES | C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-] | ||
InChI | 1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1 | ||
InChIKey | XVPBINOPNYFXID-LHDUFFHYSA-N | ||
CAS Number | 16837-52-8 | ||
ChEMBL ID | CHEMBL458337 | ||
ChEBI ID | CHEBI:2672 | ||
Herb ID | HBIN038488 | ||
Drug Bank ID | DB16276 | ||
KEGG ID | C10749 | ||
Toxicity | Organism | Test Type | Route(Dose) |
rat | LD50 | intraperitoneal(165 mg/kg) | |
mouse | LD50 | intraperitoneal(254 mg/kg) | |
rat | LD50 | oral(322 mg/kg) | |
Structure |
Download
2D
MOL
3D
MOL
|
Chineses Pinyin | KuShen | ||
Use Part | Root | ||
Habitat | China | ||
Flavor | Bitter | ||
Meridian Tropism | Heart, Liver, Stomach, Large intestine, Bladder | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora flavescens
|
Chineses Pinyin | KuDouZi | ||
Use Part | Whole grass, Seed | ||
Habitat | NeiMengGu, XinJiang, XiZang | ||
Flavor | Bitter | ||
Meridian Tropism | Heart, Lung | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora alopecuroides
|
Chineses Pinyin | ShanDouGen | ||
Use Part | Root, Rhizome | ||
Habitat | GuangXi | ||
Flavor | Bitter | ||
Meridian Tropism | Lung, Stomach | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora tonkinensis
|
Chineses Pinyin | BaiCiHua | ||
Use Part | Root | ||
Habitat | YunNan, SiChuan, GuiZhou, Shaanxi, GanSu, HeNan, ShanXi, HeBei | ||
Flavor | Bitter | ||
Meridian Tropism | Liver, Bladder | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora davidii
|
Chineses Pinyin | KuShen | ||
Use Part | Whole herb | ||
Habitat | China | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora flavescens
|
Pair Name | Oxymatrine, Paclitaxel | |||
Partner Name | Paclitaxel | |||
Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
Down-regulation | Expression | BCL-xL | hsa598 | |
Down-regulation | Expression | BIRC2 | hsa329 | |
Down-regulation | Expression | BIRC3 | hsa330 | |
Down-regulation | Expression | BIRC5 | hsa332 | |
Up-regulation | Cleavage | CASP3 | hsa836 | |
Down-regulation | Expression | COX2 | hsa4513 | |
Down-regulation | Phosphorylation | JAK1 | hsa3716 | |
Down-regulation | Phosphorylation | JAK2 | hsa3717 | |
Down-regulation | Expression | MMP9 | hsa4318 | |
Up-regulation | Cleavage | PARP1 | hsa142 | |
Down-regulation | Phosphorylation | SRC | hsa6714 | |
Down-regulation | Phosphorylation | STAT5A | KEGG ID N.A. | |
Down-regulation | Expression | VEGFA | hsa7422 | |
In Vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 |
A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 | |
In Vivo Model | In a preclinical lung cancer mouse model, OMT when used in combination with paclitaxel produced a significant reduction in tumor volume. | |||
Result | Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model |
Pair Name | Oxymatrine, Fluorouracil | |||
Partner Name | Fluorouracil | |||
Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
Biological Phenomena | Inhibition-->Epithelial-mesenchymal transition | |||
Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
Up-regulation | Expression | CDH1 | hsa999 | |
Down-regulation | Phosphorylation | RELA | hsa5970 | |
Down-regulation | Expression | SNAI2 | hsa6591 | |
Down-regulation | Expression | VIM | hsa7431 | |
In Vitro Model | HCT 8 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_2478 |
Result | Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-kappa B signaling in vitro |
No. | Title | Href |
---|---|---|
1 | Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model. Cancers (Basel). 2019 Jan 7;11(1):49. doi: 10.3390/cancers11010049. | Click |
2 | Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-κB signaling in vitro. Oncol Lett. 2020 Jan;19(1):519-526. doi: 10.3892/ol.2019.11090. | Click |