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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Oxymatrine
PubChem CID 114850
Molecular Weight 264.36g/mol
Synonyms

oxymatrine

Formula C₁₅H₂₄N₂O₂
SMILES C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]
InChI 1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1
InChIKey XVPBINOPNYFXID-LHDUFFHYSA-N
CAS Number 16837-52-8
ChEMBL ID CHEMBL458337
ChEBI ID CHEBI:2672
Herb ID HBIN038488
Drug Bank ID DB16276
KEGG ID C10749
Toxicity Organism Test Type Route(Dose)
rat LD50 intraperitoneal(165 mg/kg)
mouse LD50 intraperitoneal(254 mg/kg)
rat LD50 oral(322 mg/kg)
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
(1) Sophora flavescens Cold
Chineses Pinyin KuShen
Use Part Root
Habitat China
Flavor Bitter
Meridian Tropism Heart, Liver, Stomach, Large intestine, Bladder
Species
>Kingdom: Viridiplantae
 -->Phylum: Streptophyta
  -->Class: Equisetopsida
   -->Order: Fabales
    -->Family: Fabaceae
     -->Genus: Sophora
      -->Species: Sophora flavescens
(2) Sophora alopecuroides Cold
Chineses Pinyin KuDouZi
Use Part Whole grass, Seed
Habitat NeiMengGu, XinJiang, XiZang
Flavor Bitter
Meridian Tropism Heart, Lung
Species
>Kingdom: Viridiplantae
 -->Phylum: Streptophyta
  -->Class: Equisetopsida
   -->Order: Fabales
    -->Family: Fabaceae
     -->Genus: Sophora
      -->Species: Sophora alopecuroides
(3) Sophora tonkinensis Cold
Chineses Pinyin ShanDouGen
Use Part Root, Rhizome
Habitat GuangXi
Flavor Bitter
Meridian Tropism Lung, Stomach
Species
>Kingdom: Viridiplantae
 -->Phylum: Streptophyta
  -->Class: Equisetopsida
   -->Order: Fabales
    -->Family: Fabaceae
     -->Genus: Sophora
      -->Species: Sophora tonkinensis
(4) Sophora davidii Cool
Chineses Pinyin BaiCiHua
Use Part Root
Habitat YunNan, SiChuan, GuiZhou, Shaanxi, GanSu, HeNan, ShanXi, HeBei
Flavor Bitter
Meridian Tropism Liver, Bladder
Species
>Kingdom: Viridiplantae
 -->Phylum: Streptophyta
  -->Class: Equisetopsida
   -->Order: Fabales
    -->Family: Fabaceae
     -->Genus: Sophora
      -->Species: Sophora davidii
(5) Sophora flavescens Cold
Chineses Pinyin KuShen
Use Part Whole herb
Habitat China
Species
>Kingdom: Viridiplantae
 -->Phylum: Streptophyta
  -->Class: Equisetopsida
   -->Order: Fabales
    -->Family: Fabaceae
     -->Genus: Sophora
      -->Species: Sophora flavescens
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 18
Pair Name Oxymatrine, Paclitaxel
Partner Name Paclitaxel
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression BCL-xL hsa598
Down-regulation Expression BIRC2 hsa329
Down-regulation Expression BIRC3 hsa330
Down-regulation Expression BIRC5 hsa332
Up-regulation Cleavage CASP3 hsa836
Down-regulation Expression COX2 hsa4513
Down-regulation Phosphorylation JAK1 hsa3716
Down-regulation Phosphorylation JAK2 hsa3717
Down-regulation Expression MMP9 hsa4318
Up-regulation Cleavage PARP1 hsa142
Down-regulation Phosphorylation SRC hsa6714
Down-regulation Phosphorylation STAT5A KEGG ID N.A.
Down-regulation Expression VEGFA hsa7422
In Vitro Model NCI-H1299 Lung large cell carcinoma Homo sapiens (Human) CVCL_0060
A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
In Vivo Model In a preclinical lung cancer mouse model, OMT when used in combination with paclitaxel produced a significant reduction in tumor volume.
Result Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model
Drug(s) whose resistance can be reversed by this phytochemical
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Combination Pair ID: 19
Pair Name Oxymatrine, Fluorouracil
Partner Name Fluorouracil
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Inhibition-->Epithelial-mesenchymal transition
Gene Regulation Down-regulation Expression ABCB1 hsa5243
Up-regulation Expression CDH1 hsa999
Down-regulation Phosphorylation RELA hsa5970
Down-regulation Expression SNAI2 hsa6591
Down-regulation Expression VIM hsa7431
In Vitro Model HCT 8 Colon adenocarcinoma Homo sapiens (Human) CVCL_2478
Result Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-kappa B signaling in vitro
04. Reference
No. Title Href
1 Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model. Cancers (Basel). 2019 Jan 7;11(1):49. doi: 10.3390/cancers11010049. Click
2 Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-κB signaling in vitro. Oncol Lett. 2020 Jan;19(1):519-526. doi: 10.3892/ol.2019.11090. Click
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