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Phytochemical Details

01. General Information

Name	Oxymatrine
PubChem CID	114850
Molecular Weight	264.36g/mol
Synonyms	oxymatrine
Formula	C₁₅H₂₄N₂O₂
SMILES	C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]
InChI	1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1
InChIKey	XVPBINOPNYFXID-LHDUFFHYSA-N
CAS Number	16837-52-8
ChEMBL ID	CHEMBL458337
ChEBI ID	CHEBI:2672
Herb ID	HBIN038488
Drug Bank ID	DB16276
KEGG ID	C10749
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

02. Source Information of Phytochemical

(1) Sophora flavescens Cold

Chineses Pinyin	KuShen
Use Part	Root
Habitat	China
Flavor	Bitter
Meridian Tropism	Heart, Liver, Stomach, Large intestine, Bladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Sophora 　　　　　　-->Species: Sophora flavescens

(2) Sophora alopecuroides Cold

Chineses Pinyin	KuDouZi
Use Part	Whole grass, Seed
Habitat	NeiMengGu, XinJiang, XiZang
Flavor	Bitter
Meridian Tropism	Heart, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Sophora 　　　　　　-->Species: Sophora alopecuroides

(3) Sophora tonkinensis Cold

Chineses Pinyin	ShanDouGen
Use Part	Root, Rhizome
Habitat	GuangXi
Flavor	Bitter
Meridian Tropism	Lung, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Sophora 　　　　　　-->Species: Sophora tonkinensis

(4) Sophora davidii Cool

Chineses Pinyin	BaiCiHua
Use Part	Root
Habitat	YunNan, SiChuan, GuiZhou, Shaanxi, GanSu, HeNan, ShanXi, HeBei
Flavor	Bitter
Meridian Tropism	Liver, Bladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Sophora 　　　　　　-->Species: Sophora davidii

(5) Sophora flavescens Cold

Chineses Pinyin	KuShen
Use Part	Whole herb
Habitat	China
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Sophora 　　　　　　-->Species: Sophora flavescens

03. Combinatorial Therapeutic Effect(s)

Synergistic Effect

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Drug(s) whose efficacy can be enhanced by this phytochemical

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Combination Pair ID: 18

Ref_1

Pair Name	Oxymatrine, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BIRC2	hsa329
	Down-regulation	Expression	BIRC3	hsa330
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Phosphorylation	JAK1	hsa3716
	Down-regulation	Phosphorylation	JAK2	hsa3717
	Down-regulation	Expression	MMP9	hsa4318
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Phosphorylation	SRC	hsa6714
	Down-regulation	Phosphorylation	STAT5A	KEGG ID N.A.
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
In Vivo Model	In a preclinical lung cancer mouse model, OMT when used in combination with paclitaxel produced a significant reduction in tumor volume.
Result	Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model

Drug(s) whose resistance can be reversed by this phytochemical

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Combination Pair ID: 19

Ref_2

Pair Name	Oxymatrine, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Phosphorylation	RELA	hsa5970
	Down-regulation	Expression	SNAI2	hsa6591
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	HCT 8	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_2478
Result	Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-kappa B signaling in vitro

04. Reference

No.	Title	Href
1	Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model. Cancers (Basel). 2019 Jan 7;11(1):49. doi: 10.3390/cancers11010049.	`Click`
2	Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-κB signaling in vitro. Oncol Lett. 2020 Jan;19(1):519-526. doi: 10.3892/ol.2019.11090.	`Click`