curcumol
| Name | Curcumol | ||
| PubChem CID | 14240392 | ||
| Molecular Weight | 236.35g/mol | ||
| Synonyms |
curcumol |
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| Formula | C₁₅H₂₄O₂ | ||
| SMILES | CC1CCC2C13CC(C(O3)(CC2=C)O)C(C)C | ||
| InChI | 1S/C15H24O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h9,11-13,16H,3,5-8H2,1-2,4H3/t11-,12-,13-,14-,15+/m0/s1 | ||
| InChIKey | QRMPRVXWPCLVNI-YYFQZIEXSA-N | ||
| CAS Number | 4871-97-0 | ||
| ChEMBL ID | CHEMBL4303567 | ||
| ChEBI ID | CHEBI:173719 | ||
| Herb ID | HBIN021990 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | EZhu | ||
| Use Part | Rhizome | ||
| Habitat | ZheJiang, JiangXi, FuJian, TaiWan, HuNan, GuangDong, GuangXi, SiChuan, YunNan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma phaeocaulis
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| Chineses Pinyin | JiangHuang | ||
| Use Part | Tuberoid | ||
| Habitat | SiChuan, FuJian, GuangDong, ZheJiang, JiangXi | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Spleen, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma longa
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| Chineses Pinyin | PianJiangHuang | ||
| Use Part | Rhizome | ||
| Habitat | JiangSu, ZheJiang, FuJian, GuangDong, GuangXi, SiChuan, YunNan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Spleen, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma wenyujin
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| Chineses Pinyin | WenYuJin | ||
| Use Part | Tuberoid | ||
| Habitat | ZheJiang | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma wenyujin
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| Chineses Pinyin | YuJin | ||
| Use Part | Tuberoid | ||
| Habitat | JiangSu, ZheJiang, FuJian, GuangDong, GuangXi, JiangXi, SiChuan, YunNan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver, Heart, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma wenyujin
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| Chineses Pinyin | BaiChang | ||
| Habitat | China | ||
| Flavor | Pungent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Acorales
-->Family: Acoraceae
-->Genus: Acorus
-->Species: Acorus calamus
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| Pair Name | Curcumol, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2B51] | Osteosarcoma | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| Down-regulation | Expression | ABCC1 | hsa4363 | |
| Down-regulation | Expression | ABCG2 | hsa9429 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | K7M2-WT | Osteosarcoma | Mus musculus (Mouse) | CVCL_V455 |
| U2OS | Osteosarcoma | Homo sapiens (Human) | CVCL_0042 | |
| MG-63 | Osteosarcoma | Homo sapiens (Human) | CVCL_0426 | |
| KH OS R1 | Osteosarcoma | Homo sapiens (Human) | CVCL_T431 | |
| Result | These findings suggest that curcumol inhibits the polarization of M2-like macrophages and could be a promising combination strategy to synergize with CDDP in the osteosarcoma. | |||
| Pair Name | Curcumol, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | ABCC3 | hsa8714 |
| Up-regulation | Expression | MIR181B2 | KEGG ID N.A. | |
| Up-regulation | Activity | NFATC2 | hsa4773 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| In Vivo Model | MDA-MB-231-luc cells were suspended in a 1:1 mixture of saline/Matrigel and injected into the mammary fat pads of six-week-old female nude mice (n = 5 animals; 100 μL and 5×10⁶ cells per animal). | |||
| Result | Our study provides novel mechanistic evidence for curcumol-mediated sensitization to doxorubicin in TNBC, and it highlights the potential therapeutic usefulness of curcumol as an adjunct drug in TNBC patients with doxorubicin-resistance. | |||
| Pair Name | Curcumol, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | MIR7 | hsa10859 |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| Down-regulation | Expression | SNAI1 | hsa6615 | |
| In Vitro Model | AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 |
| MKN45 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0434 | |
| HGC-27 | Gastric carcinoma | Homo sapiens (Human) | CVCL_1279 | |
| NCI-N87 | Gastric tubular adenocarcinoma | Homo sapiens (Human) | CVCL_1603 | |
| Result | The findings may offer new thoughts that curcumol in combination with cisplatin might be a useful strategy for GC management. | |||
| Pair Name | Curcumol, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Down-regulation | Expression | NQO2 | hsa4835 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 | |
| NCI-H1975 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_1511 | |
| NCI-H358 | Minimally invasive lung adenocarcinoma | Homo sapiens (Human) | CVCL_1559 | |
| NCI-H460 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0459 | |
| In Vivo Model | BALB/c nude mice (5-week-old) were subcutaneously inoculated with A549 cells (1×10⁶) | |||
| Result | This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Curcumol Synergizes with Cisplatin in Osteosarcoma by Inhibiting M2-like Polarization of Tumor-Associated Macrophages. Molecules. 2022 Jul 6;27(14):4345. doi: 10.3390/molecules27144345. | Click |
| 2 | Curcumol enhances the sensitivity of doxorubicin in triple-negative breast cancer via regulating the miR-181b-2-3p-ABCC3 axis. Biochem Pharmacol. 2020 Apr;174:113795. doi: 10.1016/j.bcp.2020.113795. | Click |
| 3 | Curcumol enhances cisplatin sensitivity of gastric cancer: involvement of microRNA-7 and the nuclear factor-kappa B/snail family transcriptional repressor 1 axis. Bioengineered. 2022 May;13(5):11668-11683. doi: 10.1080/21655979.2022.2070975. | Click |
| 4 | Curcumol Overcomes TRAIL Resistance of Non-Small Cell Lung Cancer by Targeting NRH:Quinone Oxidoreductase 2 (NQO2). Adv Sci (Weinh). 2020 Oct 15;7(22):2002306. doi: 10.1002/advs.202002306. | Click |
