7-hydroxycoumarin, 7-hydroxycoumarin sulfate, 7-hydroxycoumarin, 14C-labeled, umbelliferone
| Name | Umbelliferone | ||
| PubChem CID | 5281426 | ||
| Molecular Weight | 162.14g/mol | ||
| Synonyms |
7-hydroxycoumarin, 7-hydroxycoumarin sulfate, 7-hydroxycoumarin, 14C-labeled, umbelliferone |
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| Formula | C₉H₆O₃ | ||
| SMILES | C1=CC(=CC2=C1C=CC(=O)O2)O | ||
| InChI | 1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H | ||
| InChIKey | ORHBXUUXSCNDEV-UHFFFAOYSA-N | ||
| CAS Number | 93-35-6 | ||
| ChEMBL ID | CHEMBL51628 | ||
| ChEBI ID | CHEBI:27510 | ||
| Herb ID | HBIN047492 | ||
| KEGG ID | C09315 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | XiangJiaLan | ||
| Use Part | Whole herb | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asparagales
-->Family: Orchidaceae
-->Genus: Vanilla
-->Species: Vanilla planifolia
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| Pair Name | Umbelliferone, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Expression | PARP1 | hsa142 | |
| Down-regulation | Phosphorylation | MEK1 | hsa5604 | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| In Vivo Model | HCT116 cells in PBS (1×10⁷ cells in 0.1 ml) were injected subcutaneously into the right axilla of nude mice. | |||
| Result | Combination of 7-hydroxycoumarin in a platinum(IV) complex derived from cisplatin enhanced cytotoxicity with multiple mechanisms of action. | |||
