Pair Name	Curcumin, Celecoxib
Partner Name	Celecoxib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Proliferation
Gene Regulation	Down-regulation	Expression	PTGS2	hsa5743
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	Our findings show the prominent anti-proliferative effects of celecoxib and/or curcumin on MDA-MB-231 cells, providing a rationale for further detailed preclinical and potential clinical studies of this combination for breast cancer therapy. Further, these computed parameters suggested that curcumin possesses a high tendency to act as an adjuvant drug with celecoxib in the treatment of breast cancer.

Pair Name	Curcumin, Disulfiram
Partner Name	Disulfiram
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Biological Phenomena	Induction-->Oxidative stress
In Vitro Model	B16-F10	Mouse melanoma	Mus musculus (Mouse)	CVCL_0159
In Vivo Model	Tumor cells (2×10⁶ cells per 500 μL) were implanted subcutaneously into the left hind groin of mice. The compounds were dissolved in 5% DMSO and provided to the mice intraperitoneally once a day for 15 consecutive days.
Result	Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress

Pair Name	Curcumin, Apatinib
Partner Name	Apatinib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BIRC5	hsa332
	Up-regulation	Expression	DIABLO	hsa56616
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	Apa-Cur combination therapy exerts more profound anti-proliferation effects on breast cancer cell than Apatinib or Curcumin monotherapy. However, further studies are required to identify other possible signaling pathways and mechanisms involved in the anticancer effects of Apatinib, Curcumin, and Apa-Cur.

Pair Name	Curcumin, Docetaxel
Partner Name	Docetaxel
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis and autophagy
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
In Vitro Model	KYSE-150	Esophageal squamous cell carcinoma	Homo sapiens (Human)	CVCL_1348
	KYSE-510	Esophageal squamous cell carcinoma	Homo sapiens (Human)	CVCL_1354
Result	CUR combined with DTX induced apoptosis and autophagy of ESCC and probably worked through the PI3K/AKT/mTOR signaling pathway. The combination of the autophagy inhibitor, CUR and DTX may become a new treatment strategy for esophageal cancer.

Pair Name	Curcumin, Arsenic oxide (As2O3)
Partner Name	Arsenic oxide (As2O3)
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	KLK2	hsa3817
	Down-regulation	Expression	SNAIL	KEGG ID N.A.
	Up-regulation	Expression	TP53	hsa7157
	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Expression	VEGFC	hsa7424
In Vitro Model	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
Result	The antitumor effects of combination therapy with As2O3 and Curcumin have been displayed on prostate cancer cell lines (LNCaP and PC3), which probably originates from their potential to induce apoptosis and inhibit the growth of prostate cancer cells simultaneously.

Pair Name	Curcumin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Gene Regulation	Down-regulation	Expression	GLS	hsa2744
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	These results indicate that curcumin could be clinically applied as an anti-chemoresistance approach against CRC by modulating miR-137-inhibited glutamine metabolism.

Pair Name	Curcumin, Olaparib
Partner Name	Olaparib
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Biological Phenomena	Inhibition-->Chromatin remodeling
Gene Regulation	Down-regulation	Expression	CHD1L	hsa9557
	Down-regulation	Expression	EP300	hsa2033
	Down-regulation	Expression	H3C1	hsa8350
	Down-regulation	Expression	PARP1	hsa142
In Vitro Model	H357	Tongue squamous cell carcinoma	Homo sapiens (Human)	CVCL_2462
Result	The present study reveals that Cur + Ola treatment increased oral cancer cell death not only through catalytic inhibition of PARP-1 but also predominantly through PARP-1 trapping and indirect inhibition of chromatin remodeling.

Pair Name	Curcumin, Anti-PD-1 antibody
Partner Name	Anti-PD-1 antibody
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Immune evasion
Gene Regulation	Down-regulation	Expression	EP300	hsa2033
	Down-regulation	Activity	SMAD2/3	KEGG ID N.A.
	Down-regulation	Expression	TGFB1	hsa7040
In Vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
In Vivo Model	Hep3B cells in the logarithmic growth phase were suspended in 50% Matrigel (BD Biosciences) and adjusted to a density of 2×10⁶ cells/mL, and 0.2 mL of single-cell suspension was subcutaneously injected into the left axilla of each mouse.
Result	Synergistic efficacy of curcumin and anti-programmed cell death-1 in hepatocellular carcinoma

Pair Name	Curcumin, Vemurafenib
Partner Name	Vemurafenib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	EGFR	hsa1956
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	A375.S2	Amelanotic melanoma	Homo sapiens (Human)	CVCL_0136
Result	Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib-resistant melanoma cells by downregulating the EGFR signaling pathway

Pair Name	Curcumin, Carboplatin
Partner Name	Carboplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->DNA damage
Gene Regulation	Up-regulation	Expression	H2AX	hsa3014
	Down-regulation	Expression	RAD51	hsa5888
	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	CAL-51	Breast carcinoma	Homo sapiens (Human)	CVCL_1110
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	Our data demonstrate that curcumin sensitizes TNBC to the anticancer effect of carboplatin by increasing ROS-induced DNA damage, thus providing an effective combination treatment strategy for TNBC.

Pair Name	Curcumin, Pyridoxine
Partner Name	Pyridoxine
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	CTNNB1	hsa1499
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
	Down-regulation	Phosphorylation	RELA	hsa5970
In Vivo Model	Male FVB mice (4 weeks old) were used in this study.
Result	C + B is superior to either agent alone in preventing obesity-promoted colorectal carcinogenesis. Augmented suppression of procancerous signaling pathways may be the means by which this augmentation occurs.

Pair Name	Curcumin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Down-regulation	Expression	KLF4	hsa9314
	Down-regulation	Expression	NANOG	hsa79923
	Down-regulation	Expression	SOX2	hsa6657
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
	NCI-H2170	Lung squamous cell carcinoma	Homo sapiens (Human)	CVCL_1535
Result	Synergistic Roles of Curcumin in Sensitising the Cisplatin Effect on a Cancer Stem Cell-Like Population Derived from Non-Small Cell Lung Cancer Cell Lines

Pair Name	Curcumin, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	EGR1	hsa1958
	Down-regulation	Expression	EP300	hsa2033
	Down-regulation	Expression	MCL1	hsa4170
	Down-regulation	Activity	NFKB1	hsa4790
	Down-regulation	Expression	RELA	hsa5970
	Up-regulation	Expression	SNIP1	hsa79753
In Vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens (Human)	CVCL_0532
	MDAH 2774	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0420
Result	Curcumin reduces paclitaxel resistance in ovarian carcinoma cells by upregulating SNIP1 and inhibiting NFκB activity

Pair Name	Curcumin, Arsenic trioxide
Partner Name	Arsenic trioxide
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	JAK2	hsa3717
	Up-regulation	Expression	PSMD9	hsa5715
	Down-regulation	Expression	STAT3	hsa6774
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	KG-1a	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_1824
In Vivo Model	All mice were inoculated with KG1-a cells via the tail vein after pretreatment of 48 h, approximately 1.0×10⁷ cells per mouse.
Result	Our results suggested that curcumin and As2O3 combination therapy exerts more significant anti-leukemia effects in the treatment of AML than curcumin or As2O3 monotherapy by up-regulating p53 pathway and down-regulating the JAK2/STAT3 pathway.

Pair Name	Curcumin, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C17]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Oxidative Stress-dependent apoptosis
Gene Regulation	Down-regulation	Expression	BIRC2	hsa329
	Up-regulation	Cleavage	CASP8	hsa841
	Down-regulation	Expression	CCR6	hsa1235
	Down-regulation	Expression	DDX3X	hsa1654
	Down-regulation	Expression	GSK3B	hsa2932
	Up-regulation	Expression	TNFRSF10B	hsa8795
In Vitro Model	HuCCA-1	Intrahepatic cholangiocarcinoma	Homo sapiens (Human)	CVCL_M255
	KKU-213A	Intrahepatic cholangiocarcinoma	Homo sapiens (Human)	CVCL_M261
Result	The present study demonstrates the potential of using curcumin in combination with TRAIL to yield better TRAIL therapy outcomes in TRAIL-resistant CCA.

Pair Name	Curcumin, Binimetinib
Partner Name	Binimetinib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Biological Phenomena	Induction-->Necroptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	MCL1	hsa4170
	Up-regulation	Phosphorylation	MLKL	hsa197259
	Up-regulation	Phosphorylation	RIPK3	hsa11035
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	G361	Glioblastoma	Homo sapiens (Human)	CVCL_C8ZL
	SK-MEL-2	Melanoma	Homo sapiens (Human)	CVCL_0069
Result	Our data demonstrates that curcumin exerts significant synergistic anticancer effects on MM cells by inducing ROS and necroptosis when combined with binimetinib. Therefore, a strategy of adding curcumin to conventional anticancer agents holds promise for treating MM.

Pair Name	Curcumin, Docetaxel
Partner Name	Docetaxel
Disease Info	[ICD-11: 2C31.Z]	Head and neck squamous cell carcinoma		Investigative
Biological Phenomena	Induction-->Immunomodulatory
Gene Regulation	Up-regulation	Expression	CD8A	hsa925
	Down-regulation	Expression	CXCL1	hsa2919
	Up-regulation	Expression	IFNG	hsa3458
	Up-regulation	Expression	TNF	hsa7124
Result	Curcumin Enhances the Efficacy of Docetaxel by Promoting Anti-Tumor Immune Response in Head and Neck Squamous Cell Carcinoma

Pair Name	Curcumin, Thalidomide
Partner Name	Thalidomide
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	STAT3	hsa6774
In Vitro Model	KG-1a	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_1824
	U-937	Adult acute monocytic leukemia	Homo sapiens (Human)	CVCL_0007
Result	Our findings suggested that down-regulation of STAT3 and BCL-XL mRNA expression in response to CUR and THAL treatment lead to inhibition of cell growth and induction of apoptosis.

Pair Name	Curcumin, Fenretinide
Partner Name	Fenretinide
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Endoplasmic reticulum stress
Gene Regulation	Down-regulation	Expression	HSPA5	hsa3309
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
In Vivo Model	LLC cells suspension (200 mL/mouse, 1×10⁷ cells/mL) was implanted carefully subcutaneously into the right side of the back of C57BL/6 mice
Result	Our findings suggest that the 2 small molecules, when used in combination, can potentially be effective therapeutic agents for treating NSCLC, at least in part, by regulating endoplasmic reticulum (ER) chaperone protein GRP78.

Pair Name	Curcumin, HSV-TK/GCV
Partner Name	HSV-TK/GCV
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Biological Phenomena	Induction-->Gap junction activity
Gene Regulation	Up-regulation	Expression	GJA1	hsa2697
	Up-regulation	Expression	GJB1	hsa2705
In Vitro Model	B16	Mouse melanoma	Mus musculus (Mouse)	CVCL_F936
In Vivo Model	A total of 2×10⁵ B16 cells in a final volume of 100L was injected into the right flanks of each C57BL/6J mouse
Result	Curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction.

Pair Name	Curcumin, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Partner Name	2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	PTEN	hsa5728
In Vitro Model	MGC-803	Gastric mucinous adenocarcinoma	Homo sapiens (Human)	CVCL_5334
Result	Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells

Pair Name	Curcumin, Nimustine
Partner Name	Nimustine
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
In Vitro Model	U-118MG	Astrocytoma	Homo sapiens (Human)	CVCL_0633
	U-87MG ATCC	Glioblastoma	Homo sapiens (Human)	CVCL_0022
	U-251MG	Astrocytoma	Homo sapiens (Human)	CVCL_0021
Result	Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-kappaB/COX-2 signaling pathways

Pair Name	Curcumin, Carfilzomib
Partner Name	Carfilzomib
Disease Info	[ICD-11: 2A83.1]	Plasma cell myeloma		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Expression	CDH13	hsa1012
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Phosphorylation	NFKBIA	hsa4792
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	U266B1	Plasma cell myeloma	Homo sapiens (Human)	CVCL_0566
Result	Curcumin significantly ameliorates CFZ cytotoxic effect. Induction of p53/p21 axis and G0/G1 cell cycle arrest were more pronounced for the CFZ-curcumin combination

Pair Name	Curcumin, ABT-888
Partner Name	ABT-888
Disease Info	[ICD-11:2B5Y]	Malignant mesenchymal neoplasm		Investigative
Biological Phenomena	Inhibition-->Homologous recombination
Gene Regulation	Up-regulation	Expression	H2AX	hsa3014
	Down-regulation	Expression	RAD51	hsa5888
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	U2OS	Osteosarcoma	Homo sapiens (Human)	CVCL_0042
In Vivo Model	2×10⁶ human MDA-MB-231 cells were prepared with 200 uL of PBS/matrigel gel (1:1 ratio) and injected subcutaneously into the flanks of athymic nude mice (two-site injections).
Result	Our study indicates that cotreatment of curcumin and PARP inhibitor might be useful for the combination chemotherapy for aggressive breast cancer treatment as a natural bioactive compound.

Pair Name	Curcumin, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CDH1	hsa999
	Up-regulation	Expression	VIM	hsa7431
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	H22	Hepatocellular carcinoma	Mus musculus (Mouse)	CVCL_H613
In Vivo Model	BALB/c mice were subcutaneously implanted with H22 cells at a concentration of 1×10⁶ cells per mouse.Therapeutic drugs (DOX, 3 mg/kg; CUR, 0.75 mg/kg) were injected into the mice in the treated groups (saline, DC, DOX/Pep2, DOX/Pep1, DC/Pep2, DC/Pep1) via the tail vein every other day for 14 days starting on day 6. The tumor sizes and mouse body weights were measured every other day.
Result	Our findings provide a novel and simple approach to nhibit the growth and metastasis of hepatocellular carcinoma.

Pair Name	Curcumin, Dactolisib
Partner Name	Dactolisib
Disease Info	[ICD-11: 2D11]	Neuroblastoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP7	hsa840
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	SH-SY5Y	Neuroblastoma	Homo sapiens (Human)	CVCL_0019
Result	Synergistic anti-proliferative and apoptotic effect of NVP-BEZ235 and curcumin on human SH-SY5Y neuroblastoma cells.

Pair Name	Curcumin, Melphalan
Partner Name	Melphalan
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP7	hsa840
	Up-regulation	Expression	CASP9	hsa842
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Expression	TP53	hsa7157
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	MCF-10A	Healthy	Homo sapiens (Human)	CVCL_0598
Result	Curcumin and melphalan cotreatment induces cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells

Pair Name	Curcumin, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CDH13	hsa1012
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Phosphorylation	MAPK3	hsa5595
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Activity	NFKB1	hsa4790
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	Combined treatment with curcumin and carboplatin inhibited tumor cell growth, migration, and invasion compared with either drug alone. The synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity

Pair Name	Curcumin, TRAIL/Apo2L
Partner Name	TRAIL/Apo2L
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	CASP9	hsa842
In Vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens (Human)	CVCL_0532
	ES-2	Ovarian clear cell adenocarcinoma	Homo sapiens (Human)	CVCL_3509
Result	Combined curcumin and Apo2L/TRAIL treatment results in enhanced induction of apoptotic cell death. Because curcumin and Apo2L/TRAIL together can activate both the extrinsic and intrinsic pathways of apoptosis, they may circumvent chemoresistance to conventional chemotherapeutic agents.

Pair Name	Curcumin, Gemcitabine
Partner Name	Gemcitabine
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
In Vivo Model	A549/GEM resistant cells were collected and resuspended with PBS and injected into the tail veins of nude mice. For each mouse, 1×10⁶ cells in 150 μL of PBS were injected.
Result	Cur reversed GEM resistance and inhibited the EMT process in A549/GEM cells. GEM, combined with Cur, is safe and more effective in the treatment of non-small cell lung cancer.

Pair Name	Curcumin, Irinotecan
Partner Name	Irinotecan
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	CD24	hsa100133941
	Down-regulation	Expression	CD44	hsa960
	Down-regulation	Expression	EPCAM	hsa4072
	Down-regulation	Expression	PROM1	hsa8842
In Vitro Model	LoVo	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0399
Result	The present data demonstrated that curcumin attenuated resistance to chemotherapeutic drugs through induction of apoptosis of CSCs among colon cancer cells. These findings may provide novel evidence for the therapeutic application of curcumin in CRC intervention.

Pair Name	Curcumin, Lenvatinib
Partner Name	Lenvatinib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	EGFR	hsa1956
	Down-regulation	Expression	MTOR	hsa2475
In Vitro Model	Huh-7	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0336
	SNU-449	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0454
	PLC/PRF/5	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0485
	SNU-398	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0077
	SK-HEP-1	Liver and intrahepatic bile duct epithelial neoplasm	Homo sapiens (Human)	CVCL_0525
Result	We report that Curcumin reverses Lenvatinib resistance in HCC, and that their combination has clinical application potential for adjunctive treatment in HCC.

Pair Name	Curcumin, Quinacrine
Partner Name	Quinacrine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Down-regulation	Expression	ABCG2	hsa9429
	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	NOS3	hsa4846
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	SP	Healthy	Homo sapiens (Human)	CVCL_C4PJ
In Vivo Model	The tumor tissue was cut into small pieces. Then, a deep incision was made in the anterior region of Balb/C mice using a scissor and then 5-6 chopped tumor tissue pieces were implanted in the anterior peritoneal wall within 3 h of collecting tumor tissues from the patient.
Result	Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A

Pair Name	Curcumin, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	L1CAM	hsa3897
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Phosphorylation	STAT1	hsa6772
In Vitro Model	SW620	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0547
In Vivo Model	SW620 cells (5×10⁶/0.1 ml Matrigel, Sigma-Aldrich) were injected subcutaneously into the lower right flank of female nude mice.
Result	We conclude that curcumin promotes chemosensitivity of CRC cells to 5-FU by downregulating L1 expression. Our findings provide experimental evidence for the synergism between curcumin and 5-FU, which can be utilized in clinical applications for reducing the toxicity and adverse effects of 5-FU.

Pair Name	Curcumin, Temozolomide
Partner Name	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BDNF	hsa627
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	HSP90AA1	hsa3320
	Down-regulation	Expression	HSPA4	hsa3308
	Down-regulation	Expression	HSPB1	hsa3315
	Up-regulation	Expression	TNF	hsa7124
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	U-87MG ATCC	Glioblastoma	Homo sapiens (Human)	CVCL_0022
Result	We showed for the first time that exosomes released from drug-treated U87 cells could be a new therapeutic approach in glioblastoma, and could reduce the side effects produced by drugs alone. This concept needs to be further examined in animal models before clinical trials could be considered.

Pair Name	Curcumin, Dasatinib
Partner Name	Dasatinib
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Cell invasion and colonosphere formation
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	Our data suggest that the combination therapy of dasatinib and curcumin may be a therapeutic strategy for re-emergence of chemo-resistant colon cancer by targeting CSC sub-population.

Pair Name	Curcumin, Warfarin
Partner Name	Warfarin
Result	Increasing the risk of bleeding