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gamma-tocotrienol, plastochromanol 8, plastochromanol 8, plastochromanol 3, tocotrienol, gamma

No.	Title	Href
1	Gamma-Tocotrienol Synergistically Promotes the Anti-proliferative and Pro-apoptotic Effects of Etoposide on Breast Cancer Cell Lines. Curr Mol Pharmacol. 2022;15(7):980-986. doi: 10.2174/1874467215666220131095611.	`Click`
2	First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. Clin Cancer Res. 2012 Apr 15;18(8):2220-9. doi: 10.1158/1078-0432.CCR-11-2470.	`Click`
3	Combined γ-tocotrienol and Met inhibitor treatment suppresses mammary cancer cell proliferation, epithelial-to-mesenchymal transition and migration. Cell Prolif. 2013 Oct;46(5):538-53. doi: 10.1111/cpr.12059.	`Click`
4	{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer Res. 2010 Nov 1;70(21):8695-705. doi: 10.1158/0008-5472.CAN-10-2318. Epub 2010 Sep 23.	`Click`
5	γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules. Br J Cancer. 2016 Sep 27;115(7):814-24. doi: 10.1038/bjc.2016.257.	`Click`
6	γ-tocotrienol enhances the chemosensitivity of human oral cancer cells to docetaxel through the downregulation of the expression of NF-κB-regulated anti-apoptotic gene products. Int J Oncol. 2013;42(1):75-82. doi:10.3892/ijo.2012.1692 through the downregulation of the expression of NF-κB-regulated anti-apoptotic gene products. Int J Oncol. 2013;42(1):75-82. doi:10.3892/ijo.2012.1692	`Click`
7	The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells. Phytother Res. 2010 Sep;24(9):1317-21. doi: 10.1002/ptr.3107.	`Click`
8	Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. Cancer Lett. 2013 Jan 28;328(2):285-96. doi: 10.1016/j.canlet.2012.10.003.	`Click`

No.

Title

Href

Gamma-Tocotrienol Synergistically Promotes the Anti-proliferative and Pro-apoptotic Effects of Etoposide on Breast Cancer Cell Lines. Curr Mol Pharmacol. 2022;15(7):980-986. doi: 10.2174/1874467215666220131095611.

Click

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. Clin Cancer Res. 2012 Apr 15;18(8):2220-9. doi: 10.1158/1078-0432.CCR-11-2470.

Click

Combined γ-tocotrienol and Met inhibitor treatment suppresses mammary cancer cell proliferation, epithelial-to-mesenchymal transition and migration. Cell Prolif. 2013 Oct;46(5):538-53. doi: 10.1111/cpr.12059.

Click

{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer Res. 2010 Nov 1;70(21):8695-705. doi: 10.1158/0008-5472.CAN-10-2318. Epub 2010 Sep 23.

Click

γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules. Br J Cancer. 2016 Sep 27;115(7):814-24. doi: 10.1038/bjc.2016.257.

Click

γ-tocotrienol enhances the chemosensitivity of human oral cancer cells to docetaxel through the downregulation of the expression of NF-κB-regulated anti-apoptotic gene products. Int J Oncol. 2013;42(1):75-82. doi:10.3892/ijo.2012.1692 through the downregulation of the expression of NF-κB-regulated anti-apoptotic gene products. Int J Oncol. 2013;42(1):75-82. doi:10.3892/ijo.2012.1692

Click

The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells. Phytother Res. 2010 Sep;24(9):1317-21. doi: 10.1002/ptr.3107.

Click

Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. Cancer Lett. 2013 Jan 28;328(2):285-96. doi: 10.1016/j.canlet.2012.10.003.

Click

Name	Gamma-Tocotrienol
PubChem CID	5282349
Molecular Weight	410.6g/mol
Synonyms	gamma-tocotrienol, plastochromanol 8, plastochromanol 8, plastochromanol 3, tocotrienol, gamma
Formula	C₂₈H₄₂O₂
SMILES	CC1=C(C=C2CCC(OC2=C1C)(C)CCC=C(C)CCC=C(C)CCC=C(C)C)O
InChI	1S/C28H42O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+/t28-/m1/s1
InChIKey	OTXNTMVVOOBZCV-WAZJVIJMSA-N
CAS Number	14101-61-2
ChEMBL ID	CHEMBL120697
ChEBI ID	CHEBI:33277
KEGG ID	C14155
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	HongHua
Use Part	Flower
Habitat	HeNan, HuNan, SiChuan, XinJiang, XiZang
Flavor	Pungent
Meridian Tropism	Heart, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asterales 　　　　-->Family: Asteraceae 　　　　　-->Genus: Carthamus 　　　　　　-->Species: Carthamus tinctorius

Chineses Pinyin	TaoRen
Use Part	Seed
Habitat	BeiJing, ShanDong, Shaanxi, HeNan, LiaoNing
Flavor	Bitter, Sweet
Meridian Tropism	Heart, Liver, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Rosaceae 　　　　　-->Genus: Prunus 　　　　　　-->Species: Prunus persica

Chineses Pinyin	HuMaYe
Use Part	Leaf
Flavor	Sweet
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Pedaliaceae 　　　　　-->Genus: Sesamum 　　　　　　-->Species: Sesamum indicum

Chineses Pinyin	ZongLv
Use Part	Petiole and fibre of sheath
Habitat	HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan
Flavor	Bitter; Astringent
Meridian Tropism	Lung; Liver; Large Intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Arecales 　　　　-->Family: Arecaceae 　　　　　-->Genus: Trachycarpus 　　　　　　-->Species: Trachycarpus fortunei

Pair Name	Gamma-Tocotrienol, Etoposide
Partner Name	Etoposide
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	Our results provide evidence for the profound anti-tumorigenic effect of combined etoposide and γ-tocotrienol in the breast cancer cell lines.

Pair Name	Gamma-Tocotrienol, Capecitabine
Partner Name	Capecitabine
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BIRC5	hsa332
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Expression	CXCR4	hsa7852
	Down-regulation	Expression	ICAM1	hsa3383
	Down-regulation	Expression	MMP9	hsa4318
	Up-regulation	Expression	PARP1	hsa142
	Down-regulation	Expression	RELA	hsa5970
	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	SNU-5	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0078
	SNU-16	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0076
	MKN45	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0434
Result	Our results show that γ-tocotrienol can potentiate the effects of capecitabine through suppression of NF-κB-regulated markers of proliferation, invasion, angiogenesis, and metastasis.

Pair Name	Gamma-Tocotrienol, SU11274
Partner Name	SU11274
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	CDH1	hsa999
	Up-regulation	Expression	CTNNB1	hsa1499
	Up-regulation	Expression	KRT18	hsa3875
	Up-regulation	Expression	KRT8	hsa3856
	Down-regulation	Phosphorylation	NFKB1	hsa4790
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
	Down-regulation	Phosphorylation	PTEN	hsa5728
	Down-regulation	Phosphorylation	STAT1	hsa6772
	Down-regulation	Phosphorylation	STAT5	hsa6776
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	+SA	The highly malignant +SA cell line was derived from an adenocarcinoma developed spontaneously in a BALB/c female mouse	Mus musculus (Mouse)	N.A.
Result	Suggest that combined γ-tocotrienol and Met inhibitor treatment may provide benefit in treatment of breast cancers characterized by aberrant Met activity.

Pair Name	Gamma-Tocotrienol, Gemcitabine
Partner Name	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BIRC2	hsa329
	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP9	hsa842
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Expression	CXCR4	hsa7852
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Expression	NFKB1	hsa4790
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	MIA PaCa-2	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0428
In Vivo Model	MIA PaCa-2 cells (1×10⁶) in 100 µL PBS were injected into the subcapsular region of the pancreas with a 27-gauge needle and a calibrated push button-controlled dispensing device.
Result	Our findings suggest that γ-T3 can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing NF-κB-mediated inflammatory pathways linked to tumorigenesis.

Pair Name	Gamma-Tocotrienol, Docetaxel
Partner Name	Docetaxel
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	APAF1	hsa317
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BIRC2	hsa329
	Down-regulation	Expression	BIRC3	hsa330
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP8	hsa841
	Up-regulation	Activity	CASP9	hsa842
	Up-regulation	Expression	CYCS	hsa54205
	Down-regulation	Expression	NFKB1	hsa4790
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	RELA	hsa5970
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	B88	Metastatic human oral cancer cell	Homo sapiens (Human)	N.A.
Result	These findings suggest that the combination treatment with these agents may provide enhanced therapeutic response in oral cancer patients, while avoiding the toxicity associated with high-dose β-tubulin stabilization monotherapy.

Pair Name	Gamma-Tocotrienol, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C51]	Mesothelioma		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
Gene Regulation	Down-regulation	Phosphorylation	BAD	hsa572
In Vitro Model	NCI-H28	Pleural sarcomatoid mesothelioma	Homo sapiens (Human)	CVCL_1555
Result	These results suggest that the combination therapy of cisplatin with TRF is a plausible strategy for achieving tolerance for the chemotherapeutic agent in MM therapy.

Pair Name	Gamma-Tocotrienol, Simvastatin
Partner Name	Simvastatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Gene Regulation	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BIRC5	hsa332
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Phosphorylation	STAT3	hsa6774
In Vitro Model	NCI-ADR-RES	High grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_1452
In Vitro Model	MCF-7/TAMR-1	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_M436
Result	Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol