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4',5,6,7,8-pentamethoxy-flavone, 4',5,6,7,8-pentamethoxyflavone, tangeretin, tangeritin

No.	Title	Href
1	Tangeretin boosts the anticancer activity of metformin in breast cancer cells via curbing the energy production. Phytomedicine. 2021 Mar;83:153470. doi: 10.1016/j.phymed.2021.153470.	`Click`
2	Synergistic therapy with tangeretin and 5-fluorouracil accelerates the ROS/JNK mediated apoptotic pathway in human colorectal cancer cell. Food Chem Toxicol. 2020 Sep;143:111529. doi: 10.1016/j.fct.2020.111529.	`Click`

No.

Title

Href

Tangeretin boosts the anticancer activity of metformin in breast cancer cells via curbing the energy production. Phytomedicine. 2021 Mar;83:153470. doi: 10.1016/j.phymed.2021.153470.

Click

Synergistic therapy with tangeretin and 5-fluorouracil accelerates the ROS/JNK mediated apoptotic pathway in human colorectal cancer cell. Food Chem Toxicol. 2020 Sep;143:111529. doi: 10.1016/j.fct.2020.111529.

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Name	Tangeretin
PubChem CID	68077
Molecular Weight	372.4g/mol
Synonyms	4',5,6,7,8-pentamethoxy-flavone, 4',5,6,7,8-pentamethoxyflavone, tangeretin, tangeritin
Formula	C₂₀H₂₀O₇
SMILES	COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC
InChI	1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
InChIKey	ULSUXBXHSYSGDT-UHFFFAOYSA-N
CAS Number	481-53-8
ChEMBL ID	CHEMBL73930
ChEBI ID	CHEBI:9400
Herb ID	HBIN045469
KEGG ID	C10190
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	GanJu
Use Part	Fruit; Peel; Juice
Habitat	JiangSu, ZheJiang, AnHui, JiangXi, HuBei, HuNan, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, TaiWan
Flavor	Sour
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Rutaceae 　　　　　-->Genus: Citrus 　　　　　　-->Species: Citrus reticulata

Pair Name	Tangeretin, Metformin
Partner Name	Metformin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->ROS accumulation
Gene Regulation	Up-regulation	Phosphorylation	PRKAA1	hsa5562
	Up-regulation	Activity	ROS1	hsa6098
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Cleavage	CASP7	hsa840
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Phosphorylation	ABCB1	hsa5243
	Down-regulation	Phosphorylation	ABCC1	hsa4363
	Down-regulation	Expression	CDK2	hsa1017
	Down-regulation	Expression	CDK4	hsa1019
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	The current work underscores the importance of metformin as an ERMA in tackling breast cancer and as a novel approach to boost its anticancer activity via a synergistic combination with tangeretin.

Pair Name	Tangeretin, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->DNA damage
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BID	hsa637
	Up-regulation	Expression	CASP9	hsa842
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Phosphorylation	RB1	hsa5925
	Up-regulation	Phosphorylation	TP53	hsa7157
	Down-regulation	Expression	TXN	KEGG ID N.A.
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	HCT 15	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0292
	KM12-C	Colon carcinoma	Homo sapiens (Human)	CVCL_9547
Result	To our knowledge gained from literature, this study is the first to describe synergistic activity of TAN and 5-FU against colorectal cancer cells.