InterPAD - DETAILS

3,4,5-trihydroxystilbene-3-beta-monoglucoside, 3,4,5-TSG, 3-hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-beta-D-glucoside, 5,4'-dihydroxystilbene-3-O-beta-D-Glcp, piceid, polydatin, polydatin, (E)-isomer, resveratrol 3-O-beta-D-glucoside, resveratrol-3-O-glucoside

No.	Title	Href
1	Targeting the ROS/PI3K/AKT/HIF-1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose. J Cell Mol Med. 2019 May;23(5):3711-3723. doi: 10.1111/jcmm.14276.	`Click`
2	Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel. J Cell Biochem. 2019 Oct;120(10):17481-17490. doi: 10.1002/jcb.29012.	`Click`
3	Natural Compounds, Optimal Combination of Brusatol and Polydatin Promote Anti-Tumor Effect in Breast Cancer by Targeting Nrf2 Signaling Pathway. Int J Mol Sci. 2023 May 5;24(9):8265. doi: 10.3390/ijms24098265.	`Click`

No.

Title

Href

Targeting the ROS/PI3K/AKT/HIF-1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose. J Cell Mol Med. 2019 May;23(5):3711-3723. doi: 10.1111/jcmm.14276.

Click

Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel. J Cell Biochem. 2019 Oct;120(10):17481-17490. doi: 10.1002/jcb.29012.

Click

Natural Compounds, Optimal Combination of Brusatol and Polydatin Promote Anti-Tumor Effect in Breast Cancer by Targeting Nrf2 Signaling Pathway. Int J Mol Sci. 2023 May 5;24(9):8265. doi: 10.3390/ijms24098265.

Click

Name	Polydatin
PubChem CID	5281718
Molecular Weight	390.4g/mol
Synonyms	3,4,5-trihydroxystilbene-3-beta-monoglucoside, 3,4,5-TSG, 3-hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-beta-D-glucoside, 5,4'-dihydroxystilbene-3-O-beta-D-Glcp, piceid, polydatin, polydatin, (E)-isomer, resveratrol 3-O-beta-D-glucoside, resveratrol-3-O-glucoside
Formula	C₂₀H₂₂O₈
SMILES	C1=CC(=CC=C1C=CC2=CC(=CC(=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O
InChI	1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16-,17-,18+,19-,20-/m1/s1
InChIKey	HSTZMXCBWJGKHG-CUYWLFDKSA-N
CAS Number	27208-80-6
ChEMBL ID	CHEMBL142652
ChEBI ID	CHEBI:8198
Herb ID	HBIN040403
Drug Bank ID	DB11263
KEGG ID	C10275
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	HuZhang
Use Part	Rhizome
Habitat	Shaanxi, GanSu, JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuBei, HuNan, SiChuan
Flavor	Mildly bitter
Meridian Tropism	Liver, Gallbladder, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Caryophyllales 　　　　-->Family: Polygonaceae 　　　　　-->Genus: Polygonum 　　　　　　-->Species: Polygonum cuspidatum

Pair Name	Polydatin, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in S phase
Gene Regulation	Up-regulation	Expression	ABCB1	hsa5243
	Up-regulation	Activity	AKT1	hsa207
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	CCNA2	hsa890
	Down-regulation	Expression	CDK2	hsa1017
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	MKI67	hsa4288
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	U2OS	Osteosarcoma	Homo sapiens (Human)	CVCL_0042
In Vitro Model	MG-63	Osteosarcoma	Homo sapiens (Human)	CVCL_0426
Result	Polydatin may enhance the chemosensitivity of osteosarcoma cells to paclitaxel.

Pair Name	Polydatin, Brusatol
Partner Name	Brusatol
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Gene Regulation	Down-regulation	Expression	HMOX1	hsa3162
	Down-regulation	Expression	NFE2L2	hsa4780
	Down-regulation	Expression	NQO1	hsa1728
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vitro Model	SUM159PT	Breast pleomorphic carcinoma	Homo sapiens (Human)	CVCL_5423
In Vivo Model	MDA-MB-231 (100 μL containing 5×10⁶ cells) were injected subcutaneously into nude mice. Until the tumor volume reached 100–200 mm3, mice in the individual administration groups were injected intraperitoneally with PD 50 mg/kg, the combined administration group was PD 25 mg/kg and BRU 1 mg/kg.
Result	We could significantly reduce tumor cell growth while avoiding toxic side effects, providing a treatment method with greater clinical application value for TNBC treatment.

Pair Name	Polydatin, 2-Deoxy-d-glucose
Partner Name	2-Deoxy-d-glucose
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Glycolysis
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	HIF1A	hsa3091
	Down-regulation	Expression	HK2	hsa3099
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Up-regulation	Expression	PARP1	hsa142
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Expression	ROS1	hsa6098
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	4T1	Malignant neoplasms of the mouse mammary gland	Mus musculus (Mouse)	CVCL_0125
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vivo Model	Approximately 2.0×10⁷ 4T1 cells without any contamination were harvested and suspended in 100 μL of PBS, then subcutaneously injected into the mouse's fourth breast pad.
Result	Our study demonstrates that PD synergised with 2-DG to enhance its anti-cancer efficacy by inhibiting the ROS/PI3K/AKT/HIF-1α/HK2 signalling axis, providing a potential anti-cancer strategy.