InterPAD - DETAILS

Cavinton, ethyl apovincaminate, ethyl apovincaminate tartrate (1:1), ethyl apovincaminate, (+-)-isomer, ethyl apovincaminate, (16alpha)-isomer, ethyl apovincaminate, (3alpha,16alpha)-isomer, ethyl apovincaminate, 2-oxopentanedioate (1:1), ethyl apovincaminate, 3H-labeled, Kavinton, RGH-4405, TCV-3B, vinpocetine

No.	Title	Href
1	Enhanced anticancer activity by the combination of vinpocetine and sorafenib via PI3K/AKT/GSK-3β signaling axis in hepatocellular carcinoma cells. Anticancer Drugs. 2021 Aug 1;32(7):727-733. doi: 10.1097/CAD.0000000000001056.	`Click`

No.

Title

Href

Enhanced anticancer activity by the combination of vinpocetine and sorafenib via PI3K/AKT/GSK-3β signaling axis in hepatocellular carcinoma cells. Anticancer Drugs. 2021 Aug 1;32(7):727-733. doi: 10.1097/CAD.0000000000001056.

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Name	Vinpocetine
PubChem CID	443955
Molecular Weight	350.5g/mol
Synonyms	Cavinton, ethyl apovincaminate, ethyl apovincaminate tartrate (1:1), ethyl apovincaminate, (+-)-isomer, ethyl apovincaminate, (16alpha)-isomer, ethyl apovincaminate, (3alpha,16alpha)-isomer, ethyl apovincaminate, 2-oxopentanedioate (1:1), ethyl apovincaminate, 3H-labeled, Kavinton, RGH-4405, TCV-3B, vinpocetine
Formula	C₂₂H₂₆N₂O₂
SMILES	CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=C2)C(=O)OCC
InChI	1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1
InChIKey	DDNCQMVWWZOMLN-IRLDBZIGSA-N
CAS Number	42971-09-5
ChEMBL ID	CHEMBL71752
ChEBI ID	CHEBI:32297
Drug Bank ID	DB12131
KEGG ID	D01371
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	ChangChunHua
Use Part	Whole herb
Habitat	JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, BeiJing, TianJin, ShanDong, JiangSu, ZheJiang, ShangHai, GuangDong, HaiNan, FuJian, TaiWan, Hongkong , HaiNan
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Gentianales 　　　　-->Family: Apocynaceae 　　　　　-->Genus: Catharanthus 　　　　　　-->Species: Catharanthus roseus

Pair Name	Vinpocetine, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Activity	GSK3B	hsa2932
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	MAP1LC3A	hsa84557
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	MCL1	hsa4170
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Phosphorylation	MTOR	hsa2475
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
In Vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
Result	Vinpocetine may be a potential candidate for sorafenib sensitization and HCC treatment, and our results may help to elucidate more effective therapeutic options for HCC patients with sorafenib resistance.