bisisomahanine, isomahanine, mahanine
| Name | Mahanine | ||
| PubChem CID | 36689305 | ||
| Molecular Weight | 347.4g/mol | ||
| Synonyms |
bisisomahanine, isomahanine, mahanine |
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| Formula | C₂₃H₂₅NO₂ | ||
| SMILES | CC1=CC2=C(C3=C1OC(C=C3)(C)CCC=C(C)C)NC4=C2C=CC(=C4)O | ||
| InChI | 1S/C23H25NO2/c1-14(2)6-5-10-23(4)11-9-18-21-19(12-15(3)22(18)26-23)17-8-7-16(25)13-20(17)24-21/h6-9,11-13,24-25H,5,10H2,1-4H3/t23-/m1/s1 | ||
| InChIKey | DWMBXHWBPZZCTN-HSZRJFAPSA-N | ||
| CAS Number | 28360-49-8 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | JiuLiXiang | ||
| Use Part | Bark or fruit | ||
| Habitat | TaiWan, FuJian, GuangDong, HaiNan, GuangXi | ||
| Flavor | Pungent; Mildly bitter | ||
| Meridian Tropism | Liver; Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Tracheophyta
-->Class: Magnoliopsida
-->Order: Malpighiales
-->Family: Clusiaceae
-->Genus: Garcinic
-->Species: Garcinic mangostana
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| Pair Name | Mahanine, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C77.Z] | Cervical cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Cleavage | CASP9 | hsa842 |
| Down-regulation | Cleavage | CASP8 | hsa841 | |
| Down-regulation | Cleavage | BID | hsa637 | |
| Down-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Phosphorylation | STAT3 | hsa6774 | |
| Down-regulation | Phosphorylation | SRC | hsa6714 | |
| Down-regulation | Phosphorylation | JAK1 | hsa3716 | |
| Down-regulation | Expression | MYC | hsa4609 | |
| Down-regulation | Expression | JUN | hsa3725 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| In Vitro Model | HeLa | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0030 |
| SiHa | Human papillomavirus-related cervical squamous cell carcinoma | Homo sapiens (Human) | CVCL_0032 | |
| Result | Our results revealed that mahanine may be a prospective agent to reduce the concentration of cisplatin in adjunct for the treatment of cancer and thereby decreasing its toxicity. | |||
| Pair Name | Mahanine, Fluorouracil | |||
| Partner Name | Fluorouracil | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Up-regulation | Expression | TP53 | hsa7157 |
| Down-regulation | Expression | TP73 | hsa7161 | |
| Up-regulation | Phosphorylation | PTEN | hsa5728 | |
| Down-regulation | Phosphorylation | MDM2 | hsa4193 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 | |
| Result | Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Improved chemosensitivity in cervical cancer to cisplatin: synergistic activity of mahanine through STAT3 inhibition. Cancer Lett. 2014 Aug 28;351(1):81-90. doi: 10.1016/j.canlet.2014.05.005. | Click |
| 2 | Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma. Apoptosis. 2024 Feb 28. doi: 10.1007/s10495-024-01951-8. | Click |
