sclareolide
| Name | Sclareolide | ||
| PubChem CID | 929262 | ||
| Molecular Weight | 250.38g/mol | ||
| Synonyms |
sclareolide |
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| Formula | C₁₆H₂₆O₂ | ||
| SMILES | CC1(CCCC2(C1CCC3(C2CC(=O)O3)C)C)C | ||
| InChI | 1S/C16H26O2/c1-14(2)7-5-8-15(3)11(14)6-9-16(4)12(15)10-13(17)18-16/h11-12H,5-10H2,1-4H3/t11-,12+,15-,16+/m0/s1 | ||
| InChIKey | IMKJGXCIJJXALX-SHUKQUCYSA-N | ||
| CAS Number | 564-20-5 | ||
| ChEMBL ID | CHEMBL304461 | ||
| ChEBI ID | CHEBI:156168 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ZiSu | ||
| Use Part | Seed | ||
| Habitat | Bhutan North , India , Indonesia , Japan , North Korea | ||
| Flavor | Pungent | ||
| Meridian Tropism | Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Perilla
-->Species: Perilla frutescens
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| Pair Name | Sclareolide, Gemcitabine | |||
| Partner Name | Gemcitabine | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | CASP3 | hsa836 |
| Up-regulation | Expression | CDH1 | hsa999 | |
| Down-regulation | Expression | GLI1 | hsa2735 | |
| Up-regulation | Expression | PARP1 | hsa142 | |
| Down-regulation | Expression | RRM1 | hsa6240 | |
| Up-regulation | Expression | SLC29A1 | hsa2030 | |
| Down-regulation | Expression | SNAI2 | hsa6591 | |
| Down-regulation | Expression | TWIST1 | hsa7291 | |
| In Vitro Model | PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0480 |
| AsPC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0152 | |
| In Vivo Model | Each BALB/c nude mouse was subcutaneously inoculated with 5×10⁶ Panc-1 or GR-Panc-1 cells in their right and left hind footpads. | |||
| Result | Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer | |||
