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2',3,4',5,7-pentahydroxyflavone, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,2',4',5,7-pentahydroxyflavone, morin, morin hydrate

No.	Title	Href
1	Morin enhances auranofin anticancer activity by up-regulation of DR4 and DR5 and modulation of Bcl-2 through reactive oxygen species generation in Hep3B human hepatocellular carcinoma cells. Phytother Res. 2019 May;33(5):1384-1393. doi: 10.1002/ptr.6329.	`Click`
2	LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy. Cancer Cell Int. 2019 Mar 21;19:67. doi: 10.1186/s12935-019-0786-1.	`Click`
3	Combination treatment with flavonoid morin and telomerase inhibitor MST‑312 reduces cancer stem cell traits by targeting STAT3 and telomerase. Int J Oncol. 2016 Aug;49(2):487-98. doi: 10.3892/ijo.2016.3546.	`Click`

No.

Title

Href

Morin enhances auranofin anticancer activity by up-regulation of DR4 and DR5 and modulation of Bcl-2 through reactive oxygen species generation in Hep3B human hepatocellular carcinoma cells. Phytother Res. 2019 May;33(5):1384-1393. doi: 10.1002/ptr.6329.

Click

LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy. Cancer Cell Int. 2019 Mar 21;19:67. doi: 10.1186/s12935-019-0786-1.

Click

Combination treatment with flavonoid morin and telomerase inhibitor MST‑312 reduces cancer stem cell traits by targeting STAT3 and telomerase. Int J Oncol. 2016 Aug;49(2):487-98. doi: 10.3892/ijo.2016.3546.

Click

Name	Morin
PubChem CID	5281670
Molecular Weight	302.23g/mol
Synonyms	2',3,4',5,7-pentahydroxyflavone, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,2',4',5,7-pentahydroxyflavone, morin, morin hydrate
Formula	C₁₅H₁₀O₇
SMILES	C1=CC(=C(C=C1O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
InChI	1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
InChIKey	YXOLAZRVSSWPPT-UHFFFAOYSA-N
CAS Number	480-16-0
ChEMBL ID	CHEMBL28626
ChEBI ID	CHEBI:75092
Herb ID	HBIN035746
Drug Bank ID	DB16770
KEGG ID	C10105
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	XiaKuCao
Use Part	Spike
Habitat	China
Flavor	Pungent, Bitter
Meridian Tropism	Liver, Gallbladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Prunella 　　　　　　-->Species: Prunella vulgaris

Chineses Pinyin	YinChen
Use Part	Whole Herb
Habitat	China
Flavor	Bitter, Pungent
Meridian Tropism	Spleen, Stomach, Liver, Gallbladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asterales 　　　　-->Family: Asteraceae 　　　　　-->Genus: Artemisia 　　　　　　-->Species: Artemisia scoparia

Chineses Pinyin	SangBaiPi
Use Part	Root Bark
Habitat	China
Flavor	Sweet
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Moraceae 　　　　　-->Genus: Morus 　　　　　　-->Species: Morus alba

Chineses Pinyin	SangShen
Use Part	Fruit Ear
Habitat	China
Flavor	Sweet, Sour
Meridian Tropism	Heart, Liver, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Moraceae 　　　　　-->Genus: Morus 　　　　　　-->Species: Morus alba

Chineses Pinyin	SangZhi
Use Part	Young Twig
Habitat	JiangSu, ZheJiang
Flavor	Mildly bitter
Meridian Tropism	Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Moraceae 　　　　　-->Genus: Morus 　　　　　　-->Species: Morus alba

Chineses Pinyin	TengHuang
Use Part	Balsam
Habitat	India , Thailand , India
Flavor	Sour, Astringent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Clusiaceae 　　　　　-->Genus: Garcinia 　　　　　　-->Species: Garcinia hanburyi

Chineses Pinyin	ShanZhuZi
Use Part	Bark, Fruit
Habitat	JiangXi, FuJian, TaiWan, GuangDong, GuangXi, YunNan
Flavor	Bitter, Astringent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Clusiaceae 　　　　　-->Genus: Garcinia 　　　　　　-->Species: Garcinia multiflora

Chineses Pinyin	YeJingJie
Use Part	Whole Herb
Habitat	XinJiang, XiZang
Flavor	Pungent
Meridian Tropism	Lung, Stomach

Chineses Pinyin	WuHuaGuo
Use Part	Fruit
Habitat	HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Moraceae 　　　　　-->Genus: Ficus 　　　　　　-->Species: Ficus carica

Pair Name	Morin, Auranofin
Partner Name	Auranofin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->ROS generation
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BIRC2	hsa329
	Down-regulation	Expression	BIRC3	hsa330
	Down-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CASP8	hsa841
	Down-regulation	Expression	CASP9	hsa842
	Up-regulation	Expression	CYCS	hsa54205
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	TNFRSF10A	hsa8797
	Up-regulation	Expression	TNFRSF10B	hsa8795
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
Result	This study provides evidence that morin can enhance the anticancer activity of AF in Hep3B human hepatocellular carcinoma cells, indicating that its combination could be an alternative treatment strategy for the hepatocellular carcinoma.

Pair Name	Morin, Fludarabine
Partner Name	Fludarabine
Disease Info	[ICD-11: 2A82]	Chronic lymphocytic leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ACP1	hsa52
	Down-regulation	Expression	CXCL12	hsa6387
	Down-regulation	Expression	CXCR4	hsa7852
	Down-regulation	Expression	ITGB1	hsa3688
In Vitro Model	MEC-1	Chronic lymphocytic leukemia	Homo sapiens (Human)	CVCL_1870
Result	Morin treatment in CLL-derived Mec-1 cell line synergizes with conventional anticancer drugs currently used in CLL therapy by affecting leukemic cell viability and trafficking.

Pair Name	Morin, MST312
Partner Name	MST312
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Gene Regulation	Up-regulation	Phosphorylation	BAD	hsa572
	Down-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Phosphorylation	NFKBIA	hsa4792
	Down-regulation	Phosphorylation	STAT3	hsa6774
	Up-regulation	Phosphorylation	TP53	hsa7157
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	SW620	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0547
Result	Our study suggests that novel targeted-therapy can be implemented by using flavonoid morin and telomerase inhibitor MST‑312 for improved cancer prognosis.