| Name | Peiminine | ||
| PubChem CID | 167691 | ||
| Molecular Weight | 429.6g/mol | ||
| Synonyms |
3beta, 20-dihydroxy-5alpha-cevan-6-one, fritillarine, imperialine, peiminine, peiminine hydrochloride, (3beta,5alpha,17beta)-isomer, peiminine nitrate salt, (3beta,5alpha,17beta)-isomer, peiminine, (3beta,5alpha,17beta)-isomer, peiminine, (3beta,5alpha,25alpha)-isomer, sipeimine, zhebeinone |
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| Formula | C₂₇H₄₃NO₃ | ||
| SMILES | CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)O)C)(C)O | ||
| InChI | 1S/C27H43NO3/c1-15-4-7-25-27(3,31)21-6-5-17-18(20(21)14-28(25)13-15)11-22-19(17)12-24(30)23-10-16(29)8-9-26(22,23)2/h15-23,25,29,31H,4-14H2,1-3H3/t15-,16-,17+,18+,19-,20-,21-,22-,23+,25-,26+,27-/m0/s1 | ||
| InChIKey | IQDIERHFZVCNRZ-YUYPDVIUSA-N | ||
| CAS Number | 18059-10-4 | ||
| ChEBI ID | CHEBI:5886 | ||
| Herb ID | HBIN039061 | ||
| KEGG ID | C10808 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ZheBeiMu | ||
| Use Part | Bulb | ||
| Habitat | ZheJiang, JiangSu, AnHui, HuNan | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung; Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Liliales
-->Family: Liliaceae
-->Genus: Fritillaria
-->Species: Fritillaria thunbergii
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| Pair Name | Peiminine, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | CCND1 | hsa595 |
| Down-regulation | Expression | EGFR | hsa1956 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Expression | PTK2 | hsa5747 | |
| In Vitro Model | SGC-7901 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0520 |
| Result | Our findings indicated that sinapine played an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells. | |||
