InterPAD - DETAILS

2-butenoic acid, 2-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo(1,2-b:5,4-b')dipyran-7-yl ester, (2Z)-, 2H,6H-benzo(1,2-b:5,4-b')dipyran-2-one, 7,8-dihydro-7-hydroxy-8,8-dimethyl-, (S)-, decursin, decursinol, decursinol angelate

No.	Title	Href
1	Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells. Evid Based Complement Alternat Med. 2013;2013:506324. doi: 10.1155/2013/506324.	`Click`
2	Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers. Br J Pharmacol. 2016 Mar;173(6):1033-44. doi: 10.1111/bph.13408.	`Click`
3	Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR-RES Ovarian Cancer Cells via Inhibition of P-glycoprotein Expression. Phytother Res. 2016 Dec;30(12):2020-2026. doi: 10.1002/ptr.5708.	`Click`

No.

Title

Href

Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells. Evid Based Complement Alternat Med. 2013;2013:506324. doi: 10.1155/2013/506324.

Click

Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers. Br J Pharmacol. 2016 Mar;173(6):1033-44. doi: 10.1111/bph.13408.

Click

Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR-RES Ovarian Cancer Cells via Inhibition of P-glycoprotein Expression. Phytother Res. 2016 Dec;30(12):2020-2026. doi: 10.1002/ptr.5708.

Click

Name	Decursin
PubChem CID	442126
Molecular Weight	328.4g/mol
Synonyms	2-butenoic acid, 2-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo(1,2-b:5,4-b')dipyran-7-yl ester, (2Z)-, 2H,6H-benzo(1,2-b:5,4-b')dipyran-2-one, 7,8-dihydro-7-hydroxy-8,8-dimethyl-, (S)-, decursin, decursinol, decursinol angelate
Formula	C₁₉H₂₀O₅
SMILES	CC(=CC(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C)C
InChI	1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
InChIKey	CUKSFECWKQBVED-INIZCTEOSA-N
CAS Number	5928-25-6
ChEMBL ID	CHEMBL481658
ChEBI ID	CHEBI:4353
Herb ID	HBIN022938
KEGG ID	C09258
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	FangFeng
Use Part	Root
Habitat	HeiLongJiang, JiLin, LiaoNing, NeiMengGu
Flavor	Pungent, Sweet
Meridian Tropism	Bladder, Liver, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Saposhnikovia 　　　　　　-->Species: Saposhnikovia divaricata

Chineses Pinyin	QianHu
Use Part	Root
Habitat	ZheJiang, HuNan, SiChuan
Flavor	Bitter, Pungent
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Peucedanum 　　　　　　-->Species: Peucedanum praeruptorum

Chineses Pinyin	ChaoXianDangGui
Use Part	Root
Habitat	HeiLongJiang, JiLin, LiaoNing
Flavor	Pungent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Angelica 　　　　　　-->Species: Angelica gigas

Chineses Pinyin	DangGui
Use Part	Root
Habitat	SiChuan, YunNan, Shaanxi, GuiZhou, QingHai, NingXia
Flavor	Pungent; Sweet
Meridian Tropism	Spleen; Liver; Heart
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Angelica 　　　　　　-->Species: Angelica sinensis

Pair Name	Decursin, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP9	hsa842
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Phosphorylation	JAK2	hsa3717
	Up-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Activity	PTPN11	hsa5781
	Down-regulation	Phosphorylation	RPS6KB1	hsa6198
	Down-regulation	Phosphorylation	SRC	hsa6714
	Down-regulation	Phosphorylation	STAT3	hsa6774
In Vitro Model	U266B1	Plasma cell myeloma	Homo sapiens (Human)	CVCL_0566
	RPMI-8226	Plasma cell myeloma	Homo sapiens (Human)	CVCL_0014
	MM.1S	Plasma cell myeloma	Homo sapiens (Human)	CVCL_8792
Result	The combination treatment of decursin and doxorubicin can enhance apoptotic activity via mTOR and/or STAT3 signaling pathway in multiple myeloma cells.

Pair Name	Decursin, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Endoplasmic reticulum stress
Gene Regulation	Up-regulation	Activity	ATF4	hsa468
	Up-regulation	Expression	DDIT3	hsa1649
	Up-regulation	Activity	EIF2AK3	hsa9451
	Up-regulation	Expression	ROS1	hsa6098
	Up-regulation	Expression	TNFRSF10B	hsa8795
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
	NCI-H596	Lung adenosquamous carcinoma	Homo sapiens (Human)	CVCL_1571
	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
	Calu-1	Lung squamous cell carcinoma	Homo sapiens (Human)	CVCL_0608
Result	ROS generation by decursin selectively activated the PERK/ATF4 axis of the endoplasmic reticulum stress signalling pathway, leading to enhanced TRAIL sensitivity in TRAIL-resistant NSCLC cell lines, partly via up-regulation of DR5.