InterPAD - DETAILS

(+)-halofuginone, (+-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone, (+-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide, (-)-halofuginone, (-)-halofuginone hydrobromide, 4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-((2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrochloride (1:1), rel-, 4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-((2S,3R)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide (1:1), 4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+-)-, 4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, trans-, mono(2-hydroxypropanoate)(salt), 6-chloro-7-bromo-(+)-febrifugine, 6-chloro-7-bromofebrifugine, 7-bromo-6-chloro-3,3-(3-hydroxy-2-piperidyl)acetonyl-4(3H)-quinazolinone-hydrolactate, 7-bromo-6-chloro-3-(3-((2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-((2S,3R)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-((2S,3R)-3-hydroxy-2-piperidyl)-2-oxo-propyl)quinazolin-4-one hydrobromide, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone, 7-bromo-6-chlorofebrifugine, Cebegine, chloro-bromofebrifugine, chlorobromofebrifugine, Halagon, Halocur, halofuginon, halofuginone, halofuginone HBr, halofuginone HCl, halofuginone hydrobromide, halofuginone hydrobromide, (-)-, halofuginone hydrochloride, halofuginone lactate, halofuginone monohydrobromide, halofuginone monohydrochloride, halofuginone, (+)-, halofuginone, (-)-, halofunginone, RU 19110, RU-19110, RU19110, Stenorol, trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone

No.	Title	Href
1	Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways. Front Cell Dev Biol. 2021 Nov 24;9:773048. doi: 10.3389/fcell.2021.773048.	`Click`

No.

Title

Href

Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways. Front Cell Dev Biol. 2021 Nov 24;9:773048. doi: 10.3389/fcell.2021.773048.

Click

Name	Halofuginone
PubChem CID	400772
Molecular Weight	414.7g/mol
Synonyms	(+)-halofuginone, (+-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone, (+-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide, (-)-halofuginone, (-)-halofuginone hydrobromide, 4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-((2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrochloride (1:1), rel-, 4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-((2S,3R)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide (1:1), 4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+-)-, 4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, trans-, mono(2-hydroxypropanoate)(salt), 6-chloro-7-bromo-(+)-febrifugine, 6-chloro-7-bromofebrifugine, 7-bromo-6-chloro-3,3-(3-hydroxy-2-piperidyl)acetonyl-4(3H)-quinazolinone-hydrolactate, 7-bromo-6-chloro-3-(3-((2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-((2S,3R)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-((2S,3R)-3-hydroxy-2-piperidyl)-2-oxo-propyl)quinazolin-4-one hydrobromide, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone, 7-bromo-6-chlorofebrifugine, Cebegine, chloro-bromofebrifugine, chlorobromofebrifugine, Halagon, Halocur, halofuginon, halofuginone, halofuginone HBr, halofuginone HCl, halofuginone hydrobromide, halofuginone hydrobromide, (-)-, halofuginone hydrochloride, halofuginone lactate, halofuginone monohydrobromide, halofuginone monohydrochloride, halofuginone, (+)-, halofuginone, (-)-, halofunginone, RU 19110, RU-19110, RU19110, Stenorol, trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone
Formula	C₁₆H₁₇BrClN₃O₃
SMILES	C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O
InChI	1S/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2/t14-,15+/m0/s1
InChIKey	LVASCWIMLIKXLA-LSDHHAIUSA-N
CAS Number	55837-20-2
ChEMBL ID	CHEMBL1199539
Drug Bank ID	DB04866
KEGG ID	D08034
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	ChangShan
Use Part	Root
Habitat	SiChuan, GuiZhou, YunNan, XiZang
Flavor	Bitter, Pungent
Meridian Tropism	Lung, Liver, Heart
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Cornales 　　　　-->Family: Hydrangeaceae 　　　　　-->Genus: Hydrangea 　　　　　　-->Species: Dichroa febrifuga

Pair Name	Halofuginone, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	CCND1	hsa595
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	PSMD9	hsa5715
	Down-regulation	Phosphorylation	RB1	hsa5925
In Vitro Model	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
In Vitro Model	NCI-H460	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0459
Result	Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways