InterPAD - DETAILS

(+)-tetrandrine, (+-)-tetrandrine, (-)-tetrandrine, (R,S)-Tetrandrine, (S,S)-tetrandrine, 6,6',7,12-tetramethoxy-2,2'-dimethyl-(1beta)-berbaman, d-tetrandrine, DL-tetrandrine, hanjisong, isotetrandrine, isotetrandrine dihydrochloride, L-tetrandrine, NSC-77037, phaeanthine, tetrandrine, tetrandrine dihydrochloride, tetrandrine dihydrochloride, (1beta)-isomer, tetrandrine, (1'beta)-isomer

No.	Title	Href
1	Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling. Br J Cancer. 2013 Jul 23;109(2):342-50. doi: 10.1038/bjc.2013.334.	`Click`
2	Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo. Cancer Lett. 2011 May 1;304(1):21-32. doi: 10.1016/j.canlet.2011.01.022.	`Click`

No.

Title

Href

Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling. Br J Cancer. 2013 Jul 23;109(2):342-50. doi: 10.1038/bjc.2013.334.

Click

Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo. Cancer Lett. 2011 May 1;304(1):21-32. doi: 10.1016/j.canlet.2011.01.022.

Click

Name	Tetrandrine
PubChem CID	73078
Molecular Weight	622.7g/mol
Synonyms	(+)-tetrandrine, (+-)-tetrandrine, (-)-tetrandrine, (R,S)-Tetrandrine, (S,S)-tetrandrine, 6,6',7,12-tetramethoxy-2,2'-dimethyl-(1beta)-berbaman, d-tetrandrine, DL-tetrandrine, hanjisong, isotetrandrine, isotetrandrine dihydrochloride, L-tetrandrine, NSC-77037, phaeanthine, tetrandrine, tetrandrine dihydrochloride, tetrandrine dihydrochloride, (1beta)-isomer, tetrandrine, (1'beta)-isomer
Formula	C₃₈H₄₂N₂O₆
SMILES	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
InChI	1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
InChIKey	WVTKBKWTSCPRNU-KYJUHHDHSA-N
CAS Number	518-34-3
ChEMBL ID	CHEMBL176045
ChEBI ID	CHEBI:49
Herb ID	HBIN046110
Drug Bank ID	DB14066
KEGG ID	C09654
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	FenFangJi
Use Part	Stephania tetrandra S. Moore
Habitat	ZheJiang, AnHui, JiangXi, FuJian, GuangDong, GuangXi
Flavor	Pungent; Bitter
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Menispermaceae 　　　　　-->Genus: Stephania 　　　　　　-->Species: Stephania tetrandra

Pair Name	Tetrandrine, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	BBC3	hsa27113
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BCL2L11	KEGG ID N.A.
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BID	hsa637
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP8	hsa841
	Up-regulation	Expression	CASP9	hsa842
	Up-regulation	Expression	CYCS	hsa54205
	Down-regulation	Expression	MCL1	hsa4170
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	BEL-7402	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_5492
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
In Vivo Model	All qualified mice were injected in the right flank with 2×10⁷ HCT116 cells suspended in 0.2 ml of PBS.
Result	The antitumour activity of sorafenib plus tetrandrine may be attributed to the induction of the intrinsic apoptosis pathway through ROS/Akt signaling. This finding provides a novel approach that may broaden the clinical application of sorafenib.

Pair Name	Tetrandrine, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CTNNB1	hsa1499
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Expression	WNT5A	hsa7474
	Down-regulation	Expression	WNT5B	hsa81029
In Vitro Model	OVCAR-3	High grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_0465
Result	Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo