4-guanidino-n-butyl syringate, leonurine, SCM-198, SCM198
Name | Leonurine | ||
PubChem CID | 161464 | ||
Molecular Weight | 311.33g/mol | ||
Synonyms |
4-guanidino-n-butyl syringate, leonurine, SCM-198, SCM198 |
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Formula | C₁₄H₂₁N₃O₅ | ||
SMILES | COC1=CC(=CC(=C1O)OC)C(=O)OCCCCN=C(N)N | ||
InChI | 1S/C14H21N3O5/c1-20-10-7-9(8-11(21-2)12(10)18)13(19)22-6-4-3-5-17-14(15)16/h7-8,18H,3-6H2,1-2H3,(H4,15,16,17) | ||
InChIKey | WNGSUWLDMZFYNZ-UHFFFAOYSA-N | ||
CAS Number | 24697-74-3 | ||
ChEMBL ID | CHEMBL1290284 | ||
ChEBI ID | CHEBI:80843 | ||
Herb ID | HBIN032907 | ||
KEGG ID | C16985 | ||
Structure |
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2D
MOL
3D
MOL
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Chineses Pinyin | YiMuCao | ||
Use Part | Aerial Parts | ||
Habitat | China | ||
Flavor | Bitter, Pungent | ||
Meridian Tropism | Liver, Pericardium, Bladder | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Leonurus
-->Species: Leonurus japonicus
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Chineses Pinyin | RouCongRong | ||
Use Part | Fleshy Stem | ||
Habitat | NeiMengGu, XinJiang, GanSu | ||
Flavor | Salty, Sweet | ||
Meridian Tropism | Kidney, Large intestine | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Orobanchaceae
-->Genus: Cistanche
-->Species: Cistanche deserticola
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Chineses Pinyin | GanDiHuang | ||
Use Part | Dried Root | ||
Habitat | HeNan, ZheJiang, JiangSu, AnHui, ShanDong, HeBei, LiaoNing, ShanXi, Shaanxi, NeiMengGu, HuNan, HuBei, SiChuan | ||
Flavor | Sweet, Bitter | ||
Meridian Tropism | Heart, Liver, Kidney | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Orobanchaceae
-->Genus: Rehmannia
-->Species: Rehmannia glutinosa
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Chineses Pinyin | XiYeYiMuCao | ||
Use Part | Aerial Parts | ||
Habitat | NeiMengGu, HeBei, ShanXi, Shaanxi, GanSu, QingHai, NingXia, XinJiang, HeiLongJiang, JiLin, LiaoNing | ||
Flavor | Bitter, Pungent | ||
Meridian Tropism | Liver, Pericardium | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Lamiaceae
-->Genus: Leonurus
-->Species: Leonurus sibiricus
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Pair Name | Leonurine, Cisplatin | |||
Partner Name | Cisplatin | |||
Disease Info | [ICD-11: 2C77] | Cervical cancer | Investigative | |
Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
Down-regulation | Expression | ABCC1 | hsa4363 | |
Up-regulation | Expression | BAX | hsa581 | |
Up-regulation | Cleavage | CASP3 | hsa836 | |
Down-regulation | Expression | MDM4 | hsa4194 | |
Up-regulation | Expression | PARP1 | hsa142 | |
In Vitro Model | C-33 A | Human papillomavirus-independent cervical squamous cell carcinoma | Homo sapiens (Human) | CVCL_1094 |
MS751 | Human papillomavirus-related cervical squamous cell carcinoma | Homo sapiens (Human) | CVCL_4996 | |
Result | Leonurine and cisplatin have synergistic antitumorigenic effects on cervical cancer. Combination with leonurine may serve as a novel strategy for enhancing cisplatin sensitivity via the inhibition of the expression of MRP1 and P-Gp. |