InterPAD - DETAILS

(2S)-naringenin, 4',5,7-trihydroxyflavanone, BE 14348A, BE-14348A, naringenin, naringenin-7-sulfate

No.	Title	Href
1	Diosmin in combination with naringenin enhances apoptosis in colon cancer cells. Oncol Rep. 2022 Jan;47(1):4. doi: 10.3892/or.2021.8215.	`Click`
2	Effect of naringenin and its combination with cisplatin in cell death, proliferation and invasion of cervical cancer spheroids. RSC Adv. 2020 Dec 22;11(1):129-141. doi: 10.1039/d0ra07309a.	`Click`
3	Glioma progression is suppressed by Naringenin and APO2L combination therapy via the activation of apoptosis in vitro and in vivo. Invest New Drugs. 2020 Dec;38(6):1743-1754. doi: 10.1007/s10637-020-00979-2.	`Click`
4	Combinatorial Effect of Temozolomide and Naringenin in Human Glioblastoma Multiforme Cell Lines. Nutr Cancer. 2022;74(3):1071-1078. doi: 10.1080/01635581.2021.1952438.	`Click`
5	Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells. Exp Ther Med. 2016 Feb;11(2):669-673. doi: 10.3892/etm.2015.2912.	`Click`

No.

Title

Href

Diosmin in combination with naringenin enhances apoptosis in colon cancer cells. Oncol Rep. 2022 Jan;47(1):4. doi: 10.3892/or.2021.8215.

Click

Effect of naringenin and its combination with cisplatin in cell death, proliferation and invasion of cervical cancer spheroids. RSC Adv. 2020 Dec 22;11(1):129-141. doi: 10.1039/d0ra07309a.

Click

Glioma progression is suppressed by Naringenin and APO2L combination therapy via the activation of apoptosis in vitro and in vivo. Invest New Drugs. 2020 Dec;38(6):1743-1754. doi: 10.1007/s10637-020-00979-2.

Click

Combinatorial Effect of Temozolomide and Naringenin in Human Glioblastoma Multiforme Cell Lines. Nutr Cancer. 2022;74(3):1071-1078. doi: 10.1080/01635581.2021.1952438.

Click

Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells. Exp Ther Med. 2016 Feb;11(2):669-673. doi: 10.3892/etm.2015.2912.

Click

Name	Naringenin
PubChem CID	439246
Molecular Weight	272.25g/mol
Synonyms	(2S)-naringenin, 4',5,7-trihydroxyflavanone, BE 14348A, BE-14348A, naringenin, naringenin-7-sulfate
Formula	C₁₅H₁₂O₅
SMILES	C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O
InChI	1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1
InChIKey	FTVWIRXFELQLPI-ZDUSSCGKSA-N
CAS Number	480-41-1
ChEMBL ID	CHEMBL9352
ChEBI ID	CHEBI:17846
Herb ID	HBIN036366
Drug Bank ID	DB03467
KEGG ID	C00509
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	FanBaiCao
Use Part	Whole herb with root
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, Shaanxi, SiChuan
Flavor	Sweet; Slightly Bitter
Meridian Tropism	Liver; Stomach; Large Intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Rosaceae 　　　　　-->Genus: Potentilla 　　　　　　-->Species: Potentilla discolor

Pair Name	Naringenin, Diosmin
Partner Name	Diosmin
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP8	hsa841
	Up-regulation	Expression	CASP9	hsa842
	Up-regulation	Expression	TP53	hsa7157
	Down-regulation	Expression	NFKB1	hsa4790
	Down-regulation	Expression	CHUK	hsa1147
	Down-regulation	Expression	IKBKB	hsa3551
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
In Vitro Model	SW480	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0546
Result	Diosmin in combination with naringenin enhances apoptosis in colon cancer cells

Pair Name	Naringenin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C77.Z]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
Result	Effect of naringenin and its combination with cisplatin in cell death, proliferation and invasion of cervical cancer spheroids

Pair Name	Naringenin, AMG-951
Partner Name	AMG-951
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	CASP9	hsa842
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	TP53	hsa7157
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	TNFRSF10A	hsa8797
	Up-regulation	Expression	TNFRSF10B	hsa8795
	Up-regulation	Expression	TRADD	hsa8717
	Up-regulation	Expression	BAD	hsa572
	Up-regulation	Expression	BAK1	hsa578
	Down-regulation	Expression	BCL2	hsa596
In Vitro Model	LN-308	Astrocytoma	Homo sapiens (Human)	CVCL_0394
In Vitro Model	U-251MG	Astrocytoma	Homo sapiens (Human)	CVCL_0021
In Vivo Model	5×10⁵ U251-MG cells were subcutaneously injected into the dorsal flanks of mice.
Result	The present study provides a novel therapeutic strategy for glioma by potentiating APO2L-induced apoptosis via the combination with NG in glioma tumor cells.

Pair Name	Naringenin, Temozolomide
Partner Name	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Inhibition-->Cell migration
In Vitro Model	U-87MG ATCC	Glioblastoma	Homo sapiens (Human)	CVCL_0022
In Vitro Model	LN-229	Glioblastoma	Homo sapiens (Human)	CVCL_0393
Result	The study showed a marked reduction in the migration of the cells and the formation of a single cell colony.

Pair Name	Naringenin, ABT-737
Partner Name	ABT-737
Disease Info	[ICD-11: 2B72.Z]	Gastric cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
Result	The combination of these drugs was found to further increase the cleavage of caspase-3 and poly ADP-ribose polymerase. Naringenin and ABT-737 also decreased Akt activation and increased p53 expression, suggesting the involvement of these pathways in the inhibition of gastric cell growth.