InterPAD - DETAILS

3,4',5-stilbenetriol, 3,4',5-Trihydroxystilbene, 3,5,4'-trihydroxystilbene, cis Resveratrol, cis-resveratrol, resveratrol, Resveratrol 3 sulfate, Resveratrol, (Z)-, resveratrol-3-sulfate, SRT 501, SRT-501, SRT501, trans Resveratrol, trans Resveratrol 3 O sulfate, trans-resveratrol, trans-resveratrol-3-O-sulfate

No.	Title	Href
1	Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest. Front Pharmacol. 2023;13:1068863. Published 2023 Jan 4. doi:10.3389/fphar.2022.1068863.	`Click`
2	Safety and Efficacy of Combined Resveratrol and Sirolimus in Lymphangioleiomyomatosis. Chest. 2023;163(5):1144-1155. doi:10.1016/j.chest.2023.01.007.	`Click`
3	Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway. CNS Neurosci Ther. 2012;18(7):536-546. doi:10.1111/j.1755-5949.2012.00319.x	`Click`
4	Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy. Free Radic Biol Med. 2012;52(2):377-391. doi:10.1016/j.freeradbiomed.2011.10.487	`Click`
5	Combination of ABT-737 and resveratrol enhances DNA damage and apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells. Toxicol In Vitro. 2017 Aug;42:38-46. doi: 10.1016/j.tiv.2017.03.013.	`Click`
6	Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004 May 21;279(21):22727-37. doi: 10.1074/jbc.M314302200.	`Click`
7	Combination of resveratrol and BIBR1532 inhibits proliferation of colon cancer cells by repressing expression of LncRNAs. Med Oncol. 2021 Nov 15;39(1):12. doi: 10.1007/s12032-021-01611-w.	`Click`
8	Resveratrol sensitizes breast cancer to PARP inhibitor, talazoparib through dual inhibition of AKT and autophagy flux. Biochem Pharmacol. 2022 May;199:115024. doi: 10.1016/j.bcp.2022.115024.	`Click`
9	Resveratrol synergizes with cisplatin in antineoplastic effects against AGS gastric cancer cells by inducing endoplasmic reticulum stress‑mediated apoptosis and G2/M phase arrest. Oncol Rep. 2020 Oct;44(4):1605-1615. doi: 10.3892/or.2020.7708.	`Click`
10	Synergistic Effects of Resveratrol and Temozolomide Against Glioblastoma Cells: Underlying Mechanism and Therapeutic Implications. Cancer Manag Res. 2020 Sep 11;12:8341-8354. doi: 10.2147/CMAR.S258584.	`Click`
11	Synergistic anticancer activity of resveratrol in combination with docetaxel in prostate carcinoma cells. Nutr Res Pract. 2021 Feb;15(1):12-25. doi: 10.4162/nrp.2021.15.1.12.	`Click`
12	Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved. Arch Biochem Biophys. 2020 Aug 15;689:108461. doi: 10.1016/j.abb.2020.108461.	`Click`
13	Olaparib enhances the Resveratrol-mediated apoptosis in breast cancer cells by inhibiting the homologous recombination repair pathway. Exp Cell Res. 2022 Nov 1;420(1):113338. doi: 10.1016/j.yexcr.2022.113338.	`Click`
14	Gemcitabine potentiates anti-tumor effect of resveratrol on pancreatic cancer via down-regulation of VEGF-B. J Cancer Res Clin Oncol. 2021 Jan;147(1):93-103. doi: 10.1007/s00432-020-03384-7.	`Click`
15	Resveratrol increases the sensitivity of breast cancer MDA-MB-231 cell line to cisplatin by regulating intrinsic apoptosis. Iran J Basic Med Sci. 2021 Jan;24(1):66-72. doi: 10.22038/ijbms.2020.50485.11501.	`Click`
16	Resveratrol Enhances Temozolomide Efficacy in Glioblastoma Cells through Downregulated MGMT and Negative Regulators-Related STAT3 Inactivation. Int J Mol Sci. 2023 May 29;24(11):9453. doi: 10.3390/ijms24119453.	`Click`
17	Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the treatment of renal cell carcinoma. Cancer Gene Ther. 2020 Aug;27(7-8):619-623. doi: 10.1038/s41417-019-0150-6.	`Click`
18	Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. Eur J Cancer Prev. 2014 Nov;23(6):506-13. doi: 10.1097/CEJ.0000000000000083.	`Click`
19	Combination of resveratrol and antiandrogen flutamide has synergistic effect on androgen receptor inhibition in prostate cancer cells. Anticancer Res. 2011;31(10):3323-3330.	`Click`
20	The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Sci Rep. 2015 Jul 9;5:12054. doi: 10.1038/srep12054.	`Click`
21	Synergistic anti-tumour activity of sorafenib in combination with pegylated resveratrol is mediated by Akt/mTOR/p70S6k-4EBP-1 and c-Raf7MEK/ERK signaling pathways. Heliyon. 2023 Aug 19;9(8):e19154. doi: 10.1016/j.heliyon.2023.e19154.	`Click`
22	Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT. Pharmaceuticals (Basel). 2023 May 17;16(5):755. doi: 10.3390/ph16050755.	`Click`

No.

Title

Href

Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest. Front Pharmacol. 2023;13:1068863. Published 2023 Jan 4. doi:10.3389/fphar.2022.1068863.

Click

Safety and Efficacy of Combined Resveratrol and Sirolimus in Lymphangioleiomyomatosis. Chest. 2023;163(5):1144-1155. doi:10.1016/j.chest.2023.01.007.

Click

Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway. CNS Neurosci Ther. 2012;18(7):536-546. doi:10.1111/j.1755-5949.2012.00319.x

Click

Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy. Free Radic Biol Med. 2012;52(2):377-391. doi:10.1016/j.freeradbiomed.2011.10.487

Click

Combination of ABT-737 and resveratrol enhances DNA damage and apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells. Toxicol In Vitro. 2017 Aug;42:38-46. doi: 10.1016/j.tiv.2017.03.013.

Click

Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004 May 21;279(21):22727-37. doi: 10.1074/jbc.M314302200.

Click

Combination of resveratrol and BIBR1532 inhibits proliferation of colon cancer cells by repressing expression of LncRNAs. Med Oncol. 2021 Nov 15;39(1):12. doi: 10.1007/s12032-021-01611-w.

Click

Resveratrol sensitizes breast cancer to PARP inhibitor, talazoparib through dual inhibition of AKT and autophagy flux. Biochem Pharmacol. 2022 May;199:115024. doi: 10.1016/j.bcp.2022.115024.

Click

Resveratrol synergizes with cisplatin in antineoplastic effects against AGS gastric cancer cells by inducing endoplasmic reticulum stress‑mediated apoptosis and G2/M phase arrest. Oncol Rep. 2020 Oct;44(4):1605-1615. doi: 10.3892/or.2020.7708.

Click

Synergistic Effects of Resveratrol and Temozolomide Against Glioblastoma Cells: Underlying Mechanism and Therapeutic Implications. Cancer Manag Res. 2020 Sep 11;12:8341-8354. doi: 10.2147/CMAR.S258584.

Click

Synergistic anticancer activity of resveratrol in combination with docetaxel in prostate carcinoma cells. Nutr Res Pract. 2021 Feb;15(1):12-25. doi: 10.4162/nrp.2021.15.1.12.

Click

Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved. Arch Biochem Biophys. 2020 Aug 15;689:108461. doi: 10.1016/j.abb.2020.108461.

Click

Olaparib enhances the Resveratrol-mediated apoptosis in breast cancer cells by inhibiting the homologous recombination repair pathway. Exp Cell Res. 2022 Nov 1;420(1):113338. doi: 10.1016/j.yexcr.2022.113338.

Click

Gemcitabine potentiates anti-tumor effect of resveratrol on pancreatic cancer via down-regulation of VEGF-B. J Cancer Res Clin Oncol. 2021 Jan;147(1):93-103. doi: 10.1007/s00432-020-03384-7.

Click

Resveratrol increases the sensitivity of breast cancer MDA-MB-231 cell line to cisplatin by regulating intrinsic apoptosis. Iran J Basic Med Sci. 2021 Jan;24(1):66-72. doi: 10.22038/ijbms.2020.50485.11501.

Click

Resveratrol Enhances Temozolomide Efficacy in Glioblastoma Cells through Downregulated MGMT and Negative Regulators-Related STAT3 Inactivation. Int J Mol Sci. 2023 May 29;24(11):9453. doi: 10.3390/ijms24119453.

Click

Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the treatment of renal cell carcinoma. Cancer Gene Ther. 2020 Aug;27(7-8):619-623. doi: 10.1038/s41417-019-0150-6.

Click

Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. Eur J Cancer Prev. 2014 Nov;23(6):506-13. doi: 10.1097/CEJ.0000000000000083.

Click

Combination of resveratrol and antiandrogen flutamide has synergistic effect on androgen receptor inhibition in prostate cancer cells. Anticancer Res. 2011;31(10):3323-3330.

Click

The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Sci Rep. 2015 Jul 9;5:12054. doi: 10.1038/srep12054.

Click

Synergistic anti-tumour activity of sorafenib in combination with pegylated resveratrol is mediated by Akt/mTOR/p70S6k-4EBP-1 and c-Raf7MEK/ERK signaling pathways. Heliyon. 2023 Aug 19;9(8):e19154. doi: 10.1016/j.heliyon.2023.e19154.

Click

Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT. Pharmaceuticals (Basel). 2023 May 17;16(5):755. doi: 10.3390/ph16050755.

Click

Name	Resveratrol
PubChem CID	445154
Molecular Weight	228.24g/mol
Synonyms	3,4',5-stilbenetriol, 3,4',5-Trihydroxystilbene, 3,5,4'-trihydroxystilbene, cis Resveratrol, cis-resveratrol, resveratrol, Resveratrol 3 sulfate, Resveratrol, (Z)-, resveratrol-3-sulfate, SRT 501, SRT-501, SRT501, trans Resveratrol, trans Resveratrol 3 O sulfate, trans-resveratrol, trans-resveratrol-3-O-sulfate
Formula	C₁₄H₁₂O₃
SMILES	C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
InChI	1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
InChIKey	LUKBXSAWLPMMSZ-OWOJBTEDSA-N
CAS Number	501-36-0
ChEMBL ID	CHEMBL165
ChEBI ID	CHEBI:27881
Herb ID	HBIN042111
Drug Bank ID	DB02709
KEGG ID	C03582
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	BaiBu
Use Part	Root
Habitat	HuBei, GuangDong, FuJian, SiChuan, GuiZhou
Flavor	Sweet, Bitter
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Pandanales 　　　　-->Family: Stemonaceae 　　　　　-->Genus: Stemona 　　　　　　-->Species: Stemona sessilifolia

Chineses Pinyin	XiaoYeMaiMaTeng
Use Part	Root; leaf; Rattan
Habitat	FuJian, GuangXi, GuangDong, YunNan
Flavor	Bitter
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Gnetales 　　　　-->Family: Gnetaceae 　　　　　-->Genus: Gnetum 　　　　　　-->Species: Gnetum parvifolium

Pair Name	Resveratrol, Temozolomide
Partner Name	Temozolomide
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Biological Phenomena	Induction-->ROS-dependent AMPK-TSC-mTOR signaling pathway
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP7	hsa840
	Up-regulation	Expression	CASP9	hsa842
	Down-regulation	Expression	CCNB1	hsa891
	Down-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Expression	LRRC59	hsa55379
	Down-regulation	Activity	MAPK1	hsa5594
	Down-regulation	Activity	MAPK14	hsa1432
	Down-regulation	Activity	MAPK8	hsa5599
	Up-regulation	Phosphorylation	TP53	hsa7157
In Vitro Model	SHG-44	Astrocytoma	Homo sapiens (Human)	CVCL_6728
In Vivo Model	SHG44 cells (5×10⁵ cells per mouse) in 5 μL of Hanks’ solution were injected intracranially into the right caudate nucleus of 6‐ to 8‐week‐old female nude mice using a screw guide technique as described
Result	TMZ in combination with resveratrol remarkably increased reactive oxygen species (ROS) production, which serves as an upstream signal for AMP-activated protein kinase (AMPK) activation. Subsequently, activated AMPK inhibited mTOR signaling and downregulated antiapoptosis protein Bcl-2, which was contributed to the additive antiproliferation effects of combination treatment. In an orthotopic xenograft model of GBM, TMZ plus resveratrol treatment significantly reduced the volume of tumor, which was confirmed by decreased expression of Ki-67, a marker of proliferation index

Pair Name	Resveratrol, Temozolomide
Partner Name	Temozolomide
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Biological Phenomena	Inhibition-->Autophagy
Gene Regulation	Down-regulation	Expression	MAP1LC3B	hsa81631
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	U-87MG ATCC	Glioblastoma	Homo sapiens (Human)	CVCL_0022
In Vivo Model	U87 MG cells in 0.1 ml MEM were subcutaneously (s.c.) injected into the right hind flank of the mice. Tumor sizes were measured with a caliper and were calculated as 1/2 × length × width2 in mm3. When the tumors grew to about 100 mm3, the tumor-bearing mice were randomly separated into treatment groups (n = 6/group).
Result	TMZ-induced ROS/ERK-mediated autophagy protected glioma cells from apoptosis, and the combination of resveratrol with TMZ could improve the efficacy of chemotherapy for brain tumors.

Pair Name	Resveratrol, ABT-737
Partner Name	ABT-737
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Biological Phenomena	Induction-->DNA damage
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	MOLT-4	Adult T acute lymphoblastic leukemia	Homo sapiens (Human)	CVCL_0013
Result	The obtained data indicate that the combination of ABT-737 and resveratrol is a promising approach for acute lymphoblastic leukemia treatment that should be further explored.

Pair Name	Resveratrol, Roscovitine
Partner Name	Roscovitine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	We propose that resveratrol inactivates COX-1 by a "hit-and-run" mechanism, and offers a basis for the design of selective COX-1 inactivators that work through a mechanism-based event at the peroxidase active site.

Pair Name	Resveratrol, BIBR1532
Partner Name	BIBR1532
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Gene Regulation	Down-regulation	Expression	CCAT1	KEGG ID N.A.
	Down-regulation	Expression	CRNDE	KEGG ID N.A.
	Down-regulation	Expression	PCAT1	KEGG ID N.A.
	Down-regulation	Expression	PVT1	KEGG ID N.A.
	Down-regulation	Expression	SNHG16	KEGG ID N.A.
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	Resveratrol, BIBR1532, or their combination may have anti-proliferative effect on colorectal cancer cells through repressing expression of LncRNAs that are involved in progression of CRC.

Pair Name	Resveratrol, Talazoparib
Partner Name	Talazoparib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	ATG5	hsa9474
	Up-regulation	Expression	ATG7	hsa10533
	Down-regulation	Expression	HR	hsa55806
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Down-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Expression	MAPK14	hsa1432
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vivo Model	Exponentially growing MCF-7 cells (5×10⁶ per mouse) were injected subcutaneously into the flank of 6 weeks old female SCID mice (weighing 25-35 g, 5 mice per group).
Result	Resveratrol sensitizes breast cancer to PARP inhibitor, talazoparib through dual inhibition of AKT and autophagy flux

Pair Name	Resveratrol, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Up-regulation	Activity	ATF4	hsa468
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP12	hsa100506742
	Down-regulation	Expression	CCNB1	hsa891
	Down-regulation	Expression	CDC25C	hsa995
	Up-regulation	Phosphorylation	CDK1	hsa983
	Up-regulation	Activity	CDKN1A	hsa1026
	Up-regulation	Activity	CDKN1B	hsa1027
	Up-regulation	Expression	DDIT3	hsa1649
	Up-regulation	Expression	EIF2AK3	hsa9451
	Up-regulation	Phosphorylation	EIF2S1	hsa1965
	Up-regulation	Expression	HSPA5	hsa3309
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	AGS	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0139
Result	These results indicated that RES is a promising adjuvant for DDP during GC chemotherapy.

Pair Name	Resveratrol, Docetaxel
Partner Name	Docetaxel
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Biological Phenomena	Induction-->Necroptosis
Gene Regulation	Up-regulation	Phosphorylation	ATM	hsa472
	Up-regulation	Phosphorylation	ATR	hsa545
	Up-regulation	Phosphorylation	H2AX	hsa3014
In Vitro Model	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
Result	We report resveratrol as an adjuvant drug candidate for improving the outcome of treatment in DTX therapy. Although the underlying mechanisms of necroptosis should be investigated comprehensively, targeting apoptosis and necroptosis simultaneously in the treatment of cancer can be a useful strategy for the development of promising drug candidates.

Pair Name	Resveratrol, Rapamycin
Partner Name	Rapamycin
Disease Info	[ICD-11: 2D10.1]	Papillary thyroid cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL-xL	hsa598
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP8	hsa841
	Up-regulation	Expression	CASP9	hsa842
	Down-regulation	Expression	MCL1	hsa4170
	Down-regulation	Phosphorylation	RPS6KB1	hsa6198
In Vitro Model	KTC-1	Poorly differentiated thyroid gland carcinoma	Homo sapiens (Human)	CVCL_6300
In Vitro Model	TPC-1	Thyroid gland papillary carcinoma	Homo sapiens (Human)	CVCL_6298
In Vivo Model	KTC-1 and TPC-1 cells in logarithmic growth phase were subcutaneously inoculated into the right armpit of nude mice (5×10⁶ cells/mouse).
Result	The present study suggests that the combination of rapamycin and resveratrol may be a promising strategy for the treatment of papillary thyroid cancer.

Pair Name	Resveratrol, Olaparib
Partner Name	Olaparib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->DNA damage
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BRCA1	hsa672
	Down-regulation	Expression	PARP1	hsa142
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vitro Model	T-47D	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0553
In Vivo Model	Tumor was induced by injecting MCF-7 cells (1 × 107 in 200 μL sterile 1X PBS) on the right breast fat pads of 6–7 weeks old female BALB/c mice. After formation of tumor, the mice were orally treated with RES + OLA combination (40 mg/kg RES and 20 nM/kg OLA per day) for 30 days.
Result	RES + OLA combination treatment enhanced breast cancer cell death by causing excessive DNA damage and also simultaneously inhibiting the HR pathway.

Pair Name	Resveratrol, Gemcitabine
Partner Name	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Phosphorylation	GSK3B	hsa2932
Gene Regulation	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	Capan-2	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0026
	MIA PaCa-2	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0428
	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
In Vivo Model	5×10⁶ MiaPaCa2 cells were suspended in DMEM medium and transplanted subcutaneously in each nude mouse.
Result	These results suggest that VEGF-B signaling pathway plays an important role in the development of PaCa and combination of GEM and RSV would be a promising modality for clinical PaCa therapy.

Pair Name	Resveratrol, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C90.0]	Renal cell carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP8	hsa841
	Up-regulation	Activity	CASP9	hsa842
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	786-O	Renal cell carcinoma	Homo sapiens (Human)	CVCL_1051
In Vitro Model	OS-RC-2	Clear cell renal cell carcinoma	Homo sapiens (Human)	CVCL_1626
In Vivo Model	These data demonstrated that RES plus Ad5/35-TRAIL significantly inhibited RCC xenograft growth in nude mice.
Result	Our data demonstrated that RES plus Ad5/35-TRAIL significantly inhibited RCC xenograft growth in nude mice. These results suggest the possibility of a new combination therapeutic leading to the improvement of RCC treatment.

Pair Name	Resveratrol, Celecoxib
Partner Name	Celecoxib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Gene Regulation	Down-regulation	Expression	COX2	hsa4513
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vivo Model	Mammary carcinogenesis was initiated with two intra peritoneal doses (50 mg/kg body weight each) of N-methyl-N-nitrosourea (NMU) dissolved in a physiological NaCl solution.
Result	This study showed that in NMU-induced mammary cancer in rats, the combination of resveratrol and celecoxib led to a significant reduction in all tumor parameters. In addition, in terms of tumor volume, the combination was more efficient than celecoxib as a single agent.

Pair Name	Resveratrol, Flutamide
Partner Name	Flutamide
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Gene Regulation	Down-regulation	Expression	AR	hsa367
In Vitro Model	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
	DU145	Prostate carcinoma	Homo sapiens (Human)	CVCL_0105
Result	Resveratrol works in concert with antiandrogen flutamide to reduce the amount and activity of AR, suggesting new therapeutic strategies for the treatment of PCa.

Pair Name	Resveratrol, Trastuzumab
Partner Name	Trastuzumab
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
Gene Regulation	Down-regulation	Expression	ERBB2	hsa2064
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vitro Model	T-47D	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0553
Result	Herceptin/resveratrol and herceptin/didox combinations improved the cytotoxic profile of herceptin in both T47D and MCF-7 breast cancer cell lines.

Pair Name	Resveratrol, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2C90.0]	Renal cell carcinoma		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	HIF1A	hsa3091
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Phosphorylation	MEK1	hsa5604
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Down-regulation	Phosphorylation	RAF1	hsa5894
	Down-regulation	Phosphorylation	RPS6KB1	hsa6198
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	RenCa	Mouse kidney carcinoma	Mus musculus (Mouse)	CVCL_2174
In Vitro Model	HEK293T	Healthy	Homo sapiens (Human)	CVCL_0063
In Vivo Model	After reaching the required number of cells, the cells were harvested, washed and appropriate amount of PBS was added to prepare Renca cell suspension at a concentration of 5×10⁷ cells/mL. 0.2 mL was injected into the armpit of each mouse, and weighed and grouped the next day.
Result	PEGylated resveratrol combined with sorafenib can achieve synergistic anti-RCC activity, and the mechanism may be related to the inhibition of Akt/mTOR/p70S6k-4EBP-1 and c-Raf7MEK/ERK signaling pathways.

Pair Name	Resveratrol, Sirolimus
Partner Name	Sirolimus
Disease Info	[ICD-11: 2F7C]	Lymphangioleiomyomatosis		Investigative
Gene Regulation	Down-regulation	Expression	VEGFD	KEGG ID N.A.
Result	The addition of resveratrol was safe and well tolerated in patients with lymphangioleiomyomatosis receiving sirolimus and was associated with modest improvement in HRQOL. Larger controlled trials of this combination may be warranted to assess definitively the usefulness of resveratrol as an additive therapy in lymphangioleiomyomatosis.