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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Trigonelline
PubChem CID 5570
Molecular Weight 137.14g/mol
Synonyms

trigonelline, trigonelline chloride, trigonelline iodide, trigonelline ion, trigonelline tosylate

Formula C₇H₇NO₂
SMILES C[N+]1=CC=CC(=C1)C(=O)[O-]
InChI 1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3
InChIKey WWNNZCOKKKDOPX-UHFFFAOYSA-N
CAS Number 535-83-1
ChEMBL ID CHEMBL350675
ChEBI ID CHEBI:18123
Herb ID HBIN047060
KEGG ID C01004
Toxicity Organism Test Type Route(Dose)
rat LD50 intraperitoneal(165 mg/kg)
mouse LD50 intraperitoneal(254 mg/kg)
rat LD50 oral(322 mg/kg)
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
Trigonella foenum-graecum Warm
Chineses Pinyin HuLuBa
Use Part Seed
Habitat AnHui, SiChuan, HeNan
Species
>Kingdom: Viridiplantae
 -->Phylum: Streptophyta
  -->Class: Equisetopsida
   -->Order: Fabales
    -->Family: Fabaceae
     -->Genus: Trigonella
      -->Species: Trigonella foenum-graecum
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 26
Pair Name Trigonelline, Cisplatin
Partner Name Cisplatin
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Down-regulation Phosphorylation EGFR hsa1956
Down-regulation Expression HMOX1 hsa3162
Down-regulation Phosphorylation MAPK1 hsa5594
Down-regulation Phosphorylation NFE2L2 hsa4780
Down-regulation Expression NQO1 hsa1728
Up-regulation Cleavage PARP1 hsa142
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
NCI-H460 Lung large cell carcinoma Homo sapiens (Human) CVCL_0459
NCI-H1299 Lung large cell carcinoma Homo sapiens (Human) CVCL_0060
Result Our study demonstrated that Trigonelline blocks Nrf2 activation and its nuclear translocation via inhibition of EGFR signalling pathway. It has improved responsiveness of NSCLC cells for Cisplatin and Etoposide and could be a promising choice for lung cancer therapy. Toxicol In Vitro. 2021 Feb;70:105038. doi: 10.1016/j.tiv.2020.105038.
04. Reference
No. Title Href
1 Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells. Toxicol In Vitro. 2021 Feb;70:105038. doi: 10.1016/j.tiv.2020.105038. Click
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