kurarinone, norkurarinone
| Name | Kurarinone | ||
| PubChem CID | 11982640 | ||
| Molecular Weight | 438.5g/mol | ||
| Synonyms |
kurarinone, norkurarinone |
||
| Formula | C₂₆H₃₀O₆ | ||
| SMILES | CC(=CCC(CC1=C2C(=C(C=C1O)OC)C(=O)CC(O2)C3=C(C=C(C=C3)O)O)C(=C)C)C | ||
| InChI | 1S/C26H30O6/c1-14(2)6-7-16(15(3)4)10-19-21(29)12-24(31-5)25-22(30)13-23(32-26(19)25)18-9-8-17(27)11-20(18)28/h6,8-9,11-12,16,23,27-29H,3,7,10,13H2,1-2,4-5H3/t16-,23+/m1/s1 | ||
| InChIKey | LTTQKYMNTNISSZ-MWTRTKDXSA-N | ||
| CAS Number | 34981-26-5 | ||
| ChEMBL ID | CHEMBL453641 | ||
| ChEBI ID | CHEBI:66150 | ||
| Herb ID | HBIN032371 | ||
| KEGG ID | C17446 | ||
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Chineses Pinyin | KuShen | ||
| Use Part | Root | ||
| Habitat | China | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Liver, Stomach, Large intestine, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Sophora
-->Species: Sophora flavescens
|
||
| Pair Name | Kurarinone, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Expression | MCL1 | hsa4170 |
| Down-regulation | Expression | CFLAR | hsa8837 | |
| Down-regulation | Expression | STAT3 | hsa6774 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Expression | CCNA2 | hsa890 | |
| Down-regulation | Expression | CCNB1 | hsa891 | |
| In Vitro Model | SGC-7901 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0520 |
| Result | Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells | |||
