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3',5'-dimethoxy-4E-stilbenol, 3',5'-dimethoxy-4trans-stilbenol, 3',5'-dimethoxy-resveratrol, 3,5-dimethoxy-4'-hydroxy-trans-stilbene, 4-((E)-2-(3,5-dimethoxyphenyl)ethenyl)phenol, 4trans-(2-(3,5-dimethoxyphenyl)ethenyl)phenol, phenol, 4-((1E)-2-(3,5-dimethoxyphenyl)ethenyl)-, pterostilbene, pterostilbene, (E)-, trans-3,5-dimethoxy-4'-hydroxystilbene, trans-pterostilbene

No.	Title	Href
1	Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8. Int J Mol Sci. 2022 Apr 4;23(7):4002. doi: 10.3390/ijms23074002.	`Click`
2	The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells. Food Funct. 2014 Aug;5(8):1856-65. doi: 10.1039/c4fo00145a.	`Click`
3	Osimertinib and pterostilbene in EGFR-mutation-positive non-small cell lung cancer (NSCLC). Int J Biol Sci. 2019 Sep 7;15(12):2607-2614. doi: 10.7150/ijbs.32889.	`Click`
4	Pterostilbene Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors and Downregulation of Cell Survival Proteins in TRAIL-Resistance Triple Negative Breast Cancer Cells. J Agric Food Chem. 2017 Dec 27;65(51):11179-11191. doi: 10.1021/acs.jafc.7b02358.	`Click`
5	Targeting MTA1/HIF-1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression. Cancer Med. 2017 Nov;6(11):2673-2685. doi: 10.1002/cam4.1209.	`Click`
6	Pterostilbene enhances sorafenib's anticancer effects on gastric adenocarcinoma. J Cell Mol Med. 2020 Nov;24(21):12525-12536. doi: 10.1111/jcmm.15795.	`Click`
7	Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity. Sci Rep. 2015 Oct 16;5:15239. doi: 10.1038/srep15239.	`Click`
8	Pterostilbene and tamoxifen show an additive effect against breast cancer in vitro. Am J Surg. 2010 Nov;200(5):577-80. doi: 10.1016/j.amjsurg.2010.07.022.	`Click`

No.

Title

Href

Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8. Int J Mol Sci. 2022 Apr 4;23(7):4002. doi: 10.3390/ijms23074002.

Click

The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells. Food Funct. 2014 Aug;5(8):1856-65. doi: 10.1039/c4fo00145a.

Click

Osimertinib and pterostilbene in EGFR-mutation-positive non-small cell lung cancer (NSCLC). Int J Biol Sci. 2019 Sep 7;15(12):2607-2614. doi: 10.7150/ijbs.32889.

Click

Pterostilbene Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors and Downregulation of Cell Survival Proteins in TRAIL-Resistance Triple Negative Breast Cancer Cells. J Agric Food Chem. 2017 Dec 27;65(51):11179-11191. doi: 10.1021/acs.jafc.7b02358.

Click

Targeting MTA1/HIF-1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression. Cancer Med. 2017 Nov;6(11):2673-2685. doi: 10.1002/cam4.1209.

Click

Pterostilbene enhances sorafenib's anticancer effects on gastric adenocarcinoma. J Cell Mol Med. 2020 Nov;24(21):12525-12536. doi: 10.1111/jcmm.15795.

Click

Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity. Sci Rep. 2015 Oct 16;5:15239. doi: 10.1038/srep15239.

Click

Pterostilbene and tamoxifen show an additive effect against breast cancer in vitro. Am J Surg. 2010 Nov;200(5):577-80. doi: 10.1016/j.amjsurg.2010.07.022.

Click

Name	Pterostilbene
PubChem CID	5281727
Molecular Weight	256.30g/mol
Synonyms	3',5'-dimethoxy-4E-stilbenol, 3',5'-dimethoxy-4trans-stilbenol, 3',5'-dimethoxy-resveratrol, 3,5-dimethoxy-4'-hydroxy-trans-stilbene, 4-((E)-2-(3,5-dimethoxyphenyl)ethenyl)phenol, 4trans-(2-(3,5-dimethoxyphenyl)ethenyl)phenol, phenol, 4-((1E)-2-(3,5-dimethoxyphenyl)ethenyl)-, pterostilbene, pterostilbene, (E)-, trans-3,5-dimethoxy-4'-hydroxystilbene, trans-pterostilbene
Formula	C₁₆H₁₆O₃
SMILES	COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC
InChI	1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
InChIKey	VLEUZFDZJKSGMX-ONEGZZNKSA-N
CAS Number	537-42-8
ChEMBL ID	CHEMBL83527
ChEBI ID	CHEBI:8630
Herb ID	HBIN041217
Drug Bank ID	DB17939
KEGG ID	C10287
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	QiangHuo
Use Part	Rhizome, Root
Habitat	SiChuan, GanSu, QingHai
Flavor	Pungent, Bitter
Meridian Tropism	Bladder, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Hansenia 　　　　　　-->Species: Hansenia weberbaueriana

Chineses Pinyin	CangBaiChengGouFeng
Use Part	Lianoid Stem
Habitat	HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan
Flavor	Mildly bitter
Meridian Tropism	Liver, Spleen, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Menispermaceae 　　　　　-->Genus: Diploclisia 　　　　　　-->Species: Diploclisia glaucescens

Chineses Pinyin	JianYeLongXueShu
Use Part	Balsam
Habitat	GuangXi, YunNan, Vietnam, Laos
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Asparagaceae 　　　　　-->Genus: Dracaena 　　　　　　-->Species: Dracaena cochinchinensis

Chineses Pinyin	Jue
Use Part	Root, Whole Herb
Habitat	China
Flavor	Sweet
Meridian Tropism	Liver, Stomach, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Polypodiales 　　　　-->Family: Dennstaedtiaceae 　　　　　-->Genus: Pteridium 　　　　　　-->Species: Pteridium aquilinum

Chineses Pinyin	KuanYeQiangHuo
Use Part	Rhizome, Root
Habitat	ShanXi, Shaanxi, HuBei, SiChuan, NeiMengGu, GanSu, QingHai
Flavor	Bitter, Pungent
Meridian Tropism	Bladder, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Hansenia 　　　　　　-->Species: Hansenia forbesii

Chineses Pinyin	LuoYanCao
Use Part	Whole Herb With Root
Habitat	YunNan, GuiZhou, GuangXi, GuangDong, FuJian, TaiWan, HuBei, HuNan
Flavor	Sweet, Mildly bitter
Meridian Tropism	Lung, Liver, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Polypodiales 　　　　-->Family: Polypodiaceae 　　　　　-->Genus: Lemmaphyllum 　　　　　　-->Species: Lemmaphyllum microphyllum

Chineses Pinyin	XiaoYeGuanZhong
Use Part	Rhizome
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, SiChuan, XiZang, Shaanxi
Flavor	Bitter
Meridian Tropism	Liver, Stomach

Chineses Pinyin	ZiTan
Use Part	Wood
Habitat	GuangDong, YunNan
Flavor	Salty
Meridian Tropism	Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Pterocarpus 　　　　　　-->Species: Pterocarpus santalinus

Chineses Pinyin	PuTao
Use Part	Vitis vinifera L
Flavor	Sweet; Slightly Sour
Meridian Tropism	Stomach; Liver; Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Vitales 　　　　-->Family: Vitaceae 　　　　　-->Genus: Vitis 　　　　　　-->Species: Vitis vinifera

Pair Name	Pterostilbene, Sunitinib
Partner Name	Sunitinib
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Oxidative Stress
Gene Regulation	Down-regulation	Expression	PDZD8	hsa118987
In Vitro Model	TMK-1	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_4384
In Vitro Model	MKN74	Gastric tubular adenocarcinoma	Homo sapiens (Human)	CVCL_2791
In Vivo Model	Subcutaneous tumor models were established by inoculating cancer cells (MKN74: 5×10⁶ per mouse, TMK-1: 1×107 per mouse) into the scapular subcutaneous tissues of nude mice on Day 0.
Result	PDZD8 may be a newly discovered off-target for SUN, and that the combined use of PTE with SUN significantly promotes antitumor activity in gastric cancer cell lines. The combined use of SUN and PTE might be a new molecular-targeted therapy for gastric cancer.

Pair Name	Pterostilbene, 3-methyladenine
Partner Name	3-methyladenine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vitro Model	BT-549	Invasive breast carcinoma	Homo sapiens (Human)	CVCL_1092
Result	These data showed that Fas signaling and autophagy accelerated the aggressiveness of TNBC. Inhibition of autophagy or Fas signaling may provide novel targets for TNBC therapy.

Pair Name	Pterostilbene, Osimertinib
Partner Name	Osimertinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	CDCP1	hsa64866
	Down-regulation	Phosphorylation	STAT3	hsa6774
	Down-regulation	Phosphorylation	YAP1	hsa10413
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	PC-9	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_B260
	NCI-H1975	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_1511
Result	The results of this study indicate that pterostilbene may be used to abrogate the activated resistance pathways of single osimertinib treatment in EGFR-mutation positive NSCLC. Future studies should focus on in vivo translation and confirmation of these results.

Pair Name	Pterostilbene, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP8	hsa841
	Up-regulation	Activity	CASP9	hsa842
	Up-regulation	Activity	DDIT3	hsa1649
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	TNFRSF10A	hsa8797
	Up-regulation	Expression	TNFRSF10B	hsa8795
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	BT-20	Invasive breast carcinoma	Homo sapiens (Human)	CVCL_0178
Result	Pterostilbene enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistance triple negative breast cancer cells

Pair Name	Pterostilbene, Vorinostat
Partner Name	Vorinostat
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Gene Regulation	Down-regulation	Expression	HIF1A	hsa3091
	Down-regulation	Expression	IL1B	hsa3553
	Down-regulation	Expression	MTA1	hsa9112
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
In Vivo Model	Female C57BL/6J mouse homozygous with "floxed" allele of Pten gene were used in this study.
Result	Our study provides preclinical evidence that Pter/SAHA combination treatment inhibits MTA1/HIF-1α tumor-promoting signaling in PCa. The beneficial outcome of combinatorial strategy using a natural agent and an approved drug for higher efficacy and less toxicity supports further development of MTA1-targeted therapies in PCa.

Pair Name	Pterostilbene, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CDK2	hsa1017
	Down-regulation	Expression	CDK4	hsa1019
	Down-regulation	Expression	CDK6	hsa1021
	Up-regulation	Expression	MAP1LC3A	hsa84557
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	SQSTM1	hsa8878
In Vitro Model	NCI-N87	Gastric tubular adenocarcinoma	Homo sapiens (Human)	CVCL_1603
In Vitro Model	MKN45	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0434
In Vivo Model	N87 cells (3×10⁵ cells) were suspended in 0.1 mL of PBS and inoculated subcutaneously into the right flank of five-week-old male BALB/c nude mice
Result	PET obviously enhanced sorafenib's antitumour effects against GAC through inhibiting cell proliferation, inducing autophagy and promoting apoptosis. The combination therapy with PET and sorafenib may serve as a novel therapeutic strategy for treating GAC and deserve further clinical trials.

Pair Name	Pterostilbene, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	FOXO1	hsa2308
	Up-regulation	Expression	IFI27	hsa3429
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
In Vitro Model	Caco-2	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0025
Result	These results provide a rationale for novel combination treatment strategies, especially for patients with 5-FU-resistant tumors expressing ER-β protein.

Pair Name	Pterostilbene, Tamoxifen
Partner Name	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vitro Model	ZR-75-1	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0588
Result	Pterostilbene shows an additive inhibitory effect on breast cancer cells when combined with tamoxifen, most likely from augmented cancer cell apoptosis.