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Phytochemical Details

01. General Information

Name	Magnolin
PubChem CID	169234
Molecular Weight	416.5g/mol
Synonyms	epimagnolin, epimagnolin A, magnolin
Formula	C₂₃H₂₈O₇
SMILES	COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC(=C(C(=C4)OC)OC)OC)OC
InChI	1S/C23H28O7/c1-24-17-7-6-13(8-18(17)25-2)21-15-11-30-22(16(15)12-29-21)14-9-19(26-3)23(28-5)20(10-14)27-4/h6-10,15-16,21-22H,11-12H2,1-5H3/t15-,16-,21+,22+/m0/s1
InChIKey	MFIHSKBTNZNJIK-RZTYQLBFSA-N
CAS Number	31008-18-1
ChEMBL ID	CHEMBL519926
Herb ID	HBIN034249
Structure		Download 2D MOL 3D MOL

02. Source Information of Phytochemical

(1) Magnolia officinalis Warm

Chineses Pinyin	HouPuHua
Use Part	Flowerbud
Habitat	SiChuan, HuBei, ZheJiang
Flavor	Bitter
Meridian Tropism	Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Magnoliales 　　　　-->Family: Magnoliaceae 　　　　　-->Genus: Magnolia 　　　　　　-->Species: Magnolia officinalis

(2) Magnolia biondii Unknown

Chineses Pinyin	WangChunYuLan
Use Part	Flower Buds
Habitat	HeNan, HuBei, SiChuan, QingDao, Shaanxi, ShanDong, GanSu
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Magnoliales 　　　　-->Family: Magnoliaceae 　　　　　-->Genus: Magnolia 　　　　　　-->Species: Magnolia biondii

(3) Yulania liliiflora Unknown

Chineses Pinyin	ZiYuLanPi
Use Part	Bark
Habitat	YunNan, FuJian, HuBei, SiChuan
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Magnoliales 　　　　-->Family: Magnoliaceae 　　　　　-->Genus: Yulania 　　　　　　-->Species: Yulania liliiflora

(4) Magnolia Liliiflora Warm

Chineses Pinyin	YinYi
Use Part	Dried flower buds
Flavor	Pungent
Meridian Tropism	Lung; Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Magnoliales 　　　　-->Family: Magnoliaceae 　　　　　-->Genus: Magnolia 　　　　　　-->Species: Magnolia Liliiflora

03. Combinatorial Therapeutic Effect(s)

Synergistic Effect

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Drug(s) whose efficacy can be enhanced by this phytochemical

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Combination Pair ID: 342

Ref_1

Pair Name	Magnolin, B-RAF Inhibitors
Partner Name	B-RAF Inhibitors
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CCND1	hsa595
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Phosphorylation	MAP2K7	hsa5609
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Expression	MTOR	hsa2475
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	PIK3CA	hsa5290
	Up-regulation	Expression	PSMD9	hsa5715
	Down-regulation	Phosphorylation	RPS6	hsa6194
	Down-regulation	Phosphorylation	RPS6KB1	hsa6198
In Vitro Model	BEL-7402	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_5492
In Vitro Model	SK-HEP-1	Liver and intrahepatic bile duct epithelial neoplasm	Homo sapiens (Human)	CVCL_0525
Result	Synergistic activity of magnolin combined with B-RAF inhibitor SB590885 in hepatocellular carcinoma cells via targeting PI3K-AKT/mTOR and ERK MAPK pathway

04. Reference

No.	Title	Href
1	Synergistic activity of magnolin combined with B-RAF inhibitor SB590885 in hepatocellular carcinoma cells via targeting PI3K-AKT/mTOR and ERK MAPK pathway. Am J Transl Res. 2019 Jun 15;11(6):3816-3824.	`Click`