icaritin
| Name | Icaritin | ||
| PubChem CID | 5318980 | ||
| Molecular Weight | 368.4g/mol | ||
| Synonyms |
icaritin |
||
| Formula | C₂₁H₂₀O₆ | ||
| SMILES | CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C(=C(O2)C3=CC=C(C=C3)OC)O)C | ||
| InChI | 1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3 | ||
| InChIKey | TUUXBSASAQJECY-UHFFFAOYSA-N | ||
| CAS Number | 118525-40-9 | ||
| ChEMBL ID | CHEMBL498485 | ||
| ChEBI ID | CHEBI:201674 | ||
| Herb ID | HBIN029965 | ||
| Drug Bank ID | DB12672 | ||
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Chineses Pinyin | ZhiMu | ||
| Use Part | Rhizome | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, NeiMengGu, HeBei, HeNan, ShanDong, Shaanxi, GanSu | ||
| Flavor | Bitter, Sweet | ||
| Meridian Tropism | Lung, Stomach, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asparagales
-->Family: Asparagaceae
-->Genus: Anemarrhena
-->Species: Anemarrhena asphodeloides
|
||
| Chineses Pinyin | ZhongJieFeng | ||
| Use Part | Whole Herb | ||
| Habitat | JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Heart, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Chloranthales
-->Family: Chloranthaceae
-->Genus: Sarcandra
-->Species: Sarcandra glabra
|
||
| Chineses Pinyin | SanKeZhen | ||
| Use Part | Root | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, ShanDong, HeNan, HuBei, SiChuan, GuiZhou, HeBei, YunNan, GanSu | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver, Stomach, Large intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Berberidaceae
-->Genus: Berberis
-->Species: Berberis soulieana
|
||
| Chineses Pinyin | YinYangHuo | ||
| Use Part | Leaf | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, ShanDong, JiangSu, JiangXi, HuNan, GuangXi, SiChuan, GuiZhou, Shaanxi, GanSu | ||
| Flavor | Pungent, Sweet | ||
| Meridian Tropism | Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Berberidaceae
-->Genus: Epimedium
-->Species: Epimedium brevicornu
|
||
| Chineses Pinyin | QianNiuZi | ||
| Use Part | Seed | ||
| Habitat | China | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung, Kidney, Large intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Solanales
-->Family: Convolvulaceae
-->Genus: Ipomoea
-->Species: Ipomoea nil
|
||
| Chineses Pinyin | ChaoXianYinYangHuo | ||
| Use Part | Aerial Parts | ||
| Habitat | North Korea, Japan , JiLin, LiaoNing, ZheJiang, AnHui | ||
| Flavor | Pungent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Berberidaceae
-->Genus: Epimedium
-->Species: Epimedium brevicornu
|
||
| Chineses Pinyin | CuMaoYinYangHuo | ||
| Use Part | Aerial Parts | ||
| Habitat | SiChuan, GuiZhou, YunNan, HuBei, GuangXi | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Berberidaceae
-->Genus: Epimedium
-->Species: Epimedium acuminatum
|
||
| Chineses Pinyin | WanShanYinYangHuo | ||
| Use Part | Aerial Parts | ||
| Habitat | Shaanxi, GanSu, ShanXi, HeNan, QingHai, HuBei, SiChuan | ||
| Flavor | Pungent, Sweet | ||
| Meridian Tropism | Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Berberidaceae
-->Genus: Epimedium
-->Species: Epimedium brevicornu
|
||
| Pair Name | Icaritin, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Down-regulation | Expression | CFLAR | hsa8837 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| In Vitro Model | U-373MG ATCC | Astrocytoma | Homo sapiens (Human) | CVCL_2219 |
| U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 | |
| Result | These data suggest that icaritin sensitizes TRAIL-induced tumor cell apoptosis via suppression of NF-κB-dependent c-FLIP expression, providing in vitro evidence supporting the notion that icaritin is a potential sensitizer of TRAIL in anticancer therapy against human GBM. | |||
