InterPAD - DETAILS

All trans Lycopene, all-trans-lycopene, LYC O MATO, LYC-O-MATO, LYCOMATO, lycopene, lycopene, (13-cis)-isomer, Lycopene, (7-cis,7'-cis,9-cis,9'-cis)-isomer -, lycopene, (cis)-isomer, Pro Lycopene, Pro-Lycopene, prolycopene

No.	Title	Href
1	Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells. Cancer Cell Int. 2019 Mar 21;19:68. doi: 10.1186/s12935-019-0789-y.	`Click`
2	Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway. Biochem Biophys Res Commun. 2022 Jul 12;613:53-60. doi: 10.1016/j.bbrc.2022.04.126.	`Click`
3	Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factor- kappa B (NF-κB) pathway. Turk J Med Sci. 2021 Feb 26;51(1):368-374. doi: 10.3906/sag-2005-413.	`Click`
4	Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells. Int J Med Sci. 2020 Apr 6;17(8):1015-1022. doi: 10.7150/ijms.40131.	`Click`
5	Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells. J Nutr Biochem. 2009 Jun;20(6):426-34. doi: 10.1016/j.jnutbio.2008.05.001.	`Click`
6	Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway. J Nutr Biochem. 2012 Sep;23(9):1155-62. doi: 10.1016/j.jnutbio.2011.06.009.	`Click`

No.

Title

Href

Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells. Cancer Cell Int. 2019 Mar 21;19:68. doi: 10.1186/s12935-019-0789-y.

Click

Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway. Biochem Biophys Res Commun. 2022 Jul 12;613:53-60. doi: 10.1016/j.bbrc.2022.04.126.

Click

Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factor- kappa B (NF-κB) pathway. Turk J Med Sci. 2021 Feb 26;51(1):368-374. doi: 10.3906/sag-2005-413.

Click

Anti-cancer therapeutic benefit of red guava extracts as a potential therapy in combination with doxorubicin or targeted therapy for triple-negative breast cancer cells. Int J Med Sci. 2020 Apr 6;17(8):1015-1022. doi: 10.7150/ijms.40131.

Click

Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells. J Nutr Biochem. 2009 Jun;20(6):426-34. doi: 10.1016/j.jnutbio.2008.05.001.

Click

Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway. J Nutr Biochem. 2012 Sep;23(9):1155-62. doi: 10.1016/j.jnutbio.2011.06.009.

Click

Name	Lycopene
PubChem CID	446925
Molecular Weight	536.9g/mol
Synonyms	All trans Lycopene, all-trans-lycopene, LYC O MATO, LYC-O-MATO, LYCOMATO, lycopene, lycopene, (13-cis)-isomer, Lycopene, (7-cis,7'-cis,9-cis,9'-cis)-isomer -, lycopene, (cis)-isomer, Pro Lycopene, Pro-Lycopene, prolycopene
Formula	C₄₀H₅₆
SMILES	CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C
InChI	1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+
InChIKey	OAIJSZIZWZSQBC-GYZMGTAESA-N
CAS Number	502-65-8
ChEMBL ID	CHEMBL501174
ChEBI ID	CHEBI:15948
Herb ID	HBIN033972
Drug Bank ID	DB11231
KEGG ID	C05432
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	MeiGuiHua
Use Part	Bud
Habitat	BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, NingXia, XinJiang, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, Japan , North Korea
Flavor	Sweet, Mildly bitter
Meridian Tropism	Liver, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Rosaceae 　　　　　-->Genus: Rosa 　　　　　　-->Species: Rosa rugosa

Chineses Pinyin	NanHeShi
Use Part	Fruit
Habitat	JiangSu, HeNan, HuBei, ZheJiang
Flavor	Bitter, Pungent
Meridian Tropism	Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Daucus 　　　　　　-->Species: Daucus carota

Chineses Pinyin	ShenJinCao
Habitat	HuBei
Flavor	Mildly bitter, Pungent
Meridian Tropism	Liver, Spleen, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lycopodiales 　　　　-->Family: Lycopodiaceae 　　　　　-->Genus: Lycopodium 　　　　　　-->Species: Lycopodium japonicum

Chineses Pinyin	ShiDi
Use Part	Calyx
Habitat	HeBei, HeNan, ShanDong
Flavor	Bitter, Astringent
Meridian Tropism	Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ericales 　　　　-->Family: Ebenaceae 　　　　　-->Genus: Diospyros 　　　　　　-->Species: Diospyros kaki

Chineses Pinyin	ShiYe
Use Part	Leaf
Habitat	HeBei, HeNan, ShanDong
Flavor	Bitter
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ericales 　　　　-->Family: Ebenaceae 　　　　　-->Genus: Diospyros 　　　　　　-->Species: Diospyros kaki

Chineses Pinyin	HuaJuHong
Use Part	Pericarp
Habitat	ZheJiang, JiangXi, FuJian, TaiWan, HuBei, HuNan, GuangDong, GuangXi, SiChuan, GuiZhou, YunNan
Flavor	Pungent, Bitter
Meridian Tropism	Lung, Spleen

Chineses Pinyin	FanQie
Use Part	Fresh Fruit
Habitat	China
Flavor	Sour, Sweet
Meridian Tropism	Liver, Lung, Stomach

Chineses Pinyin	JinZhanJu
Use Part	Flower, Root
Habitat	FuJian, GuangDong, GuangXi, SiChuan, GuiZhou, YunNan
Flavor	Bitter
Meridian Tropism	Liver, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asterales 　　　　-->Family: Asteraceae 　　　　　-->Genus: Calendula 　　　　　　-->Species: Calendula officinalis

Chineses Pinyin	KuGua
Use Part	Fruit
Habitat	China
Flavor	Bitter
Meridian Tropism	Heart, Spleen, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Cucurbitales 　　　　-->Family: Cucurbitaceae 　　　　　-->Genus: Momordica 　　　　　　-->Species: Momordica charantia

Chineses Pinyin	QianCengTa
Use Part	Whole Herb
Habitat	HeiLongJiang, JiLin, LiaoNing, SiChuan, GuiZhou, YunNan, XiZang, ChongQing
Flavor	Bitter, Mildly sweet
Meridian Tropism	Lung, Large intestine, Liver, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lycopodiales 　　　　-->Family: Lycopodiaceae 　　　　　-->Genus: Huperzia 　　　　　　-->Species: Huperzia serrata

Chineses Pinyin	XiaoJieJinCao
Use Part	Whole Herb
Habitat	JiLin, Shaanxi, YunNan, SiChuan, XinJiang
Flavor	Mildly bitter
Meridian Tropism	Heart
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lycopodiales 　　　　-->Family: Lycopodiaceae 　　　　　-->Genus: Huperzia 　　　　　　-->Species: Huperzia selago

Chineses Pinyin	YeHuLuoBo
Use Part	Root, Fruit
Habitat	SiChuan, GuiZhou, HuBei, JiangXi, AnHui, JiangSu
Flavor	Bitter, Pungent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Daucus 　　　　　　-->Species: Daucus carota

Chineses Pinyin	ZhongYaShaJi
Use Part	Fruit
Habitat	XinJiang
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Elaeagnaceae 　　　　　-->Genus: Hippophae 　　　　　　-->Species: Hippophae rhamnoides

Pair Name	Lycopene, Anti-PD-1 antibody
Partner Name	Anti-PD-1 antibody
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Immunomodulatory
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	CXCL10	KEGG ID N.A.
	Up-regulation	Expression	CXCL9	KEGG ID N.A.
	Down-regulation	Expression	DNMT3A	KEGG ID N.A.
	Up-regulation	Expression	IFNG	hsa3458
	Up-regulation	Expression	IRF1	hsa3659
	Up-regulation	Expression	IRF7	KEGG ID N.A.
	Up-regulation	Phosphorylation	JAK2	hsa3717
	Down-regulation	Expression	PD-L1	KEGG ID N.A.
	Up-regulation	Phosphorylation	STAT3	hsa6774
In Vitro Model	3LL	Malignant tumors of the mouse pulmonary system	Mus musculus (Mouse)	CVCL_5653
In Vivo Model	Lewis lung carcinoma (LLC) cells (1×10⁶) were injected in the rear flak of C57BL/6 mice
Result	lycopene promoted anti-PD-1 therapeutic efficiency of lung cancer by promoting IFNγ-expressing CD8+ cells infiltrated in tumor tissues and increasing IFNγ expression in tumor cells.

Pair Name	Lycopene, Enzalutamide
Partner Name	Enzalutamide
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	AR	hsa367
	Down-regulation	Phosphorylation	EZH2	hsa2146
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	PCNA	hsa5111
In Vitro Model	LNCaP C4-2B	Prostate carcinoma	Homo sapiens (Human)	CVCL_4784
In Vitro Model	22Rv1	Prostate carcinoma	Homo sapiens (Human)	CVCL_1045
In Vivo Model	22RV1 cells (2×10⁶) were injected into left tibia or the right flank of nude mice.
Result	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.

Pair Name	Lycopene, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Oxidative Stress
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	CDH13	hsa1012
	Up-regulation	Expression	NFE2L2	hsa4780
	Down-regulation	Expression	NFKB1	hsa4790
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
Result	Lycopene increases the sensitization of cervical cancer cells to cisplatin via inhibition of cell viability, up-regulation of Bax expression, and down-regulation of Bcl-2 expression. Furthermore, the anticancer effect of lycopene might be also associated with suppression of NF-κB-mediated inflammatory responses, and modulation of Nrf2-mediated oxidative stress. The results of the present study suggest that lycopene and concurrent cisplatin chemotherapy might have a role in improving the treatment of cervical cancer.

Pair Name	Lycopene, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
Gene Regulation	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vitro Model	MDA-MB-468	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0419
Result	Our results thus show the therapeutic benefit of red guava extracts as a potential cancer treatment for TNBC in combination with doxorubicin or targeted therapy.

Pair Name	Lycopene, Eicosapentaenoic acid
Partner Name	Eicosapentaenoic acid
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	FAS	hsa355
	Down-regulation	Phosphorylation	MTOR	hsa2475
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	Our novel findings suggest that lycopene and EPA synergistically inhibited the growth of human colon cancer HT-29 cells even at low concentration. The inhibitory effects of lycopene and EPA on cell proliferation of human colon cancer HT-29 cells were, in part, associated with the down-regulation of the PI-3K/Akt/mTOR signaling pathway.

Pair Name	Lycopene, T0901317
Partner Name	T0901317
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Inhibition-->Cell proliferation
Gene Regulation	Up-regulation	Expression	ABCA1	hsa19
	Up-regulation	Expression	NR1H3	hsa10062
	Up-regulation	Expression	PPARG	hsa5468
In Vitro Model	DU145	Prostate carcinoma	Homo sapiens (Human)	CVCL_0105
In Vitro Model	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
Result	These results demonstrate that lycopene can inhibit DU145 cell proliferation via PPARγ-LXRα-ABCA1 pathway and that lycopene and T0901317 exhibit synergistic effects.