liriodenine
| Name | Liriodenine | ||
| PubChem CID | 10144 | ||
| Molecular Weight | 275.26g/mol | ||
| Synonyms |
liriodenine |
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| Formula | C₁₇H₉NO₃ | ||
| SMILES | C1OC2=C(O1)C3=C4C(=C2)C=CN=C4C(=O)C5=CC=CC=C53 | ||
| InChI | 1S/C17H9NO3/c19-16-11-4-2-1-3-10(11)14-13-9(5-6-18-15(13)16)7-12-17(14)21-8-20-12/h1-7H,8H2 | ||
| InChIKey | MUMCCPUVOAUBAN-UHFFFAOYSA-N | ||
| CAS Number | 475-75-2 | ||
| ChEMBL ID | CHEMBL37736 | ||
| ChEBI ID | CHEBI:70649 | ||
| Herb ID | HBIN033393 | ||
| KEGG ID | C09567 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | EZhangQiu | ||
| Use Part | Leaf; Bark | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Magnoliales
-->Family: Magnoliaceae
-->Genus: Liriodendron
-->Species: Liriodendron chinense
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| Pair Name | Liriodenine, Valproic acid | |||
| Partner Name | Valproic acid | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | PARP1 | hsa142 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | GCLC | hsa2729 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| In Vitro Model | DLD-1 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0248 |
| HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 | |
| Result | Liriodenine enhances the apoptosis effect of valproic acid in human colon cancer cells through oxidative stress upregulation and Akt inhibition | |||
