Pair Name	Luteolin, IL-24
Partner Name	Luteolin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	PARP1	hsa142
In Vitro Model	L-02	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_6926
	MHCC97-H	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_4972
	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	PLC/PRF/5	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0485
	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
In Vivo Model	The xenograft model was established by subcutaneously injection of 4×10⁶ MHCC97-H cells into the right flank of these female BALB/c nude mice (5 weeks old).
Result	These data confirm that the synergistic mechanism of VV-IL-24 and luteolin elicits a stronger tumor growth inhibition than any single therapy. Thus, the combination of VV-IL-24 and luteolin could provide the basis for preclinical research in the treatment of liver cancer.