1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro(1,10,9,8-opqra)perylene-7,14-dione, hipericin, hypericin, hypericum red, mono-(123I)iodohypericin, SGX-301, SGX301
| Name | Hypericin | ||
| PubChem CID | 3663 | ||
| Molecular Weight | 504.4g/mol | ||
| Synonyms |
1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro(1,10,9,8-opqra)perylene-7,14-dione, hipericin, hypericin, hypericum red, mono-(123I)iodohypericin, SGX-301, SGX301 |
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| Formula | C₃₀H₁₆O₈ | ||
| SMILES | CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O | ||
| InChI | 1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,33-38H,1-2H3 | ||
| InChIKey | YDOIFHVUBCIUHF-UHFFFAOYSA-N | ||
| CAS Number | 548-04-9 | ||
| ChEMBL ID | CHEMBL286494 | ||
| ChEBI ID | CHEBI:5835 | ||
| Herb ID | HBIN029828 | ||
| Drug Bank ID | DB13014 | ||
| KEGG ID | C07606 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | LianQiao | ||
| Use Part | Fruit | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung, Heart, Small intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Oleaceae
-->Genus: Forsythia
-->Species: Forsythia suspensa
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| Chineses Pinyin | DiErCao | ||
| Use Part | Whole Herb | ||
| Habitat | HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Liver, Gallbladder, Large intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Hypericaceae
-->Genus: Hypericum
-->Species: Hypericum japonicum
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| Chineses Pinyin | BianDiJin | ||
| Use Part | Whole Herb | ||
| Habitat | SiChuan, GuiZhou, YunNan | ||
| Flavor | Bitter, Astringent | ||
| Meridian Tropism | Large intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Hypericaceae
-->Genus: Hypericum
-->Species: Hypericum wightianum
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| Chineses Pinyin | GuanYeLianQiao | ||
| Use Part | Whole Herb With Root | ||
| Habitat | HeBei, Shaanxi, GanSu, XinJiang, ShanDong, JiangSu, JiangXi, HeNan, HuBei, HuNan, SiChuan, GuiZhou | ||
| Flavor | Bitter, Astringent | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Hypericaceae
-->Genus: Hypericum
-->Species: Hypericum perforatum
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| Chineses Pinyin | HuangHaiTang | ||
| Use Part | Whole Herb | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Hypericaceae
-->Genus: Hypericum
-->Species: Hypericum ascyron
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| Chineses Pinyin | JinSiMei | ||
| Use Part | Whole Herb | ||
| Habitat | JiangSu, ZheJiang, AnHui, FuJian, JiangXi, HuBei, HuNan, GuangXi, SiChuan, GuiZhou, Shaanxi, GanSu, TaiWan | ||
| Flavor | Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Hypericaceae
-->Genus: Hypericum
-->Species: Hypericum patulum
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| Chineses Pinyin | XiaoLianQiao | ||
| Use Part | Whole Herb | ||
| Habitat | China | ||
| Flavor | Pungent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Hypericaceae
-->Genus: Hypericum
-->Species: Hypericum erectum
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| Chineses Pinyin | YuanBaoCao | ||
| Use Part | Whole Herb | ||
| Habitat | HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Hypericaceae
-->Genus: Hypericum
-->Species: Hypericum sampsonii
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| Chineses Pinyin | ZhanEJinSiTao | ||
| Use Part | Root, Stem, Fruit, Aerial Parts | ||
| Habitat | YunNan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Hypericaceae
-->Genus: Hypericum
-->Species: Hypericum lancasteri
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| Pair Name | Hypericin, Gemcitabine | |||
| Partner Name | Gemcitabine | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Expression | CYCS | hsa54205 | |
| Down-regulation | Expression | DCTPP1 | hsa79077 | |
| Down-regulation | Expression | H6PD | hsa9563 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | Capan-2 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0026 |
| Result | We demonstrated that Gem combined HY-PDT could inhibit the proliferation of Capan-2 cells and induce cell apoptosis. HY-PDT combined with Gem had a great potential on pancreatic cancer treatment clinically. | |||
