InterPAD - DETAILS

quinacrine, mepacrine, atabrine, 83-89-6, Acrinamine, Acriquine, Erion, Antimalarina, Haffkinine, Quinactine, Akrichin, Italchine, acrichine, Mepacrinum, Quinacrine hydrochloride, St 439, 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine, 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, Malaricida, Methoquine, Italchin, Metochin, Palacrin, Palusan, Pentilen, Mecryl, 3-Chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine, 2-Methoxy-6-chloro-9-diethylaminopentylaminoacridine, CHEMBL7568, H0C805XYDE, Mepacrine hydrochloride, CHEBI:8711, GNF-PF-5448, Quinacrine (hydrochloride,hydrate), Mepacrine (INN), chinacrin, Acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, MEPACRINE [INN], N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine, 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine, Atabrine hydrochloride dihydrate; Mepacrine hydrochloride, Mepacrina, Quinacrin, Mepacrine [INN:BAN], Mepacrinum [INN-Latin], Mepacrina [INN-Spanish], 6-CHLORO-N-[5-(DIETHYLAMINO)PENTAN-2-YL]-2-METHOXYACRIDIN-9-AMINE, N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine, N(4)-(6-chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine, Quinacrine, Mepacrine, HSDB 3253, EINECS 201-508-7, UNII-H0C805XYDE, Acirchine, 6-chloro-N-(5-(diethylamino)pentan-2-yl)-2-methoxyacridin-9-amine, AI3-04467, CCRIS 3726, CCRIS 8633, Acridine, 6-chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxy-, N~4~-(6-chloro-2-methoxyacridin-9-yl)-N~1~,N~1~-diethylpentane-1,4-diamine, Quinacrine,Mepacrine, Atebrin (Salt/Mix), Atebrine (Salt/Mix), Spectrum_000929, QUINACRINE [MI], Prestwick0_000318, Prestwick1_000318, Prestwick2_000318, Prestwick3_000318, Spectrum2_000888, Spectrum3_000606, Spectrum4_000496, Spectrum5_001405, (.+/-.)-Quinacrine, QUINACRINE [HSDB], QUINACRINE [VANDF], MEPACRINE [WHO-DD], Lopac0_000970, SCHEMBL19225, BSPBio_000316, BSPBio_002112, KBioGR_001011, KBioGR_002507, KBioSS_001409, KBioSS_002515, DivK1c_000101, SPBio_000676, SPBio_002535, BPBio1_000348, DTXSID7022627, GTPL10172, KBio1_000101, KBio2_001409, KBio2_002507, KBio2_003977, KBio2_005075, KBio2_006545, KBio2_007643, KBio3_001612, KBio3_002985, cMAP_000067, NINDS_000101, HMS2090L03, BBL028456, BDBM50015214, RP-866 (Dihydrochloride dihydrate), SN-390 (Dihydrochloride dihydrate), STL061087, AKOS000541535, AKOS016340229, CCG-205050, DB01103, MS-1557, SDCCGSBI-0050943.P006, IDI1_000101, N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine, NCGC00015874-02, NCGC00015874-03, NCGC00015874-04, NCGC00015874-08, NCGC00015874-12, NCGC00162300-01, HY-13735, NCI60_000926, SBI-0050943.P004, AB00053540, CS-0007762, FT-0674264, FT-0778222, NS00003697, C07339, D08179, EN300-246511, AB00053540-08, AB00053540-09, AB00053540_10, Q417208, BRD-A45889380-300-04-8, BRD-A45889380-336-03-4, Z31251611, 2-Methoxy-6-chloro-9-diethylaminopent-2-ylaminoacridine, 6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-methylbutyl)amine, acridine, 3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)-, acridine, 3-chloro-9-(4-diethylamino-1-methyl)butylamino-7-methoxy-, N''-(6-chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine, N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylpentane-1,4-diamine, N4-(6-chloro-2-methoxy-acridin-9-yl)-N1,N1-diethyl-pentane-1,4-diamine, N'-(6-Chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine dihydrochloride, N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine (Mepacrine), N~4~-[6-chloro-2-(methyloxy)acridin-9-yl]-N~1~,N~1~-diethylpentane-1,4-diamine, N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine ; (mepacrine)

Name	Quinacrine
PubChem CID	237
Molecular Weight	400.0g/mol
Synonyms	quinacrine, mepacrine, atabrine, 83-89-6, Acrinamine, Acriquine, Erion, Antimalarina, Haffkinine, Quinactine, Akrichin, Italchine, acrichine, Mepacrinum, Quinacrine hydrochloride, St 439, 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine, 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, Malaricida, Methoquine, Italchin, Metochin, Palacrin, Palusan, Pentilen, Mecryl, 3-Chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine, 2-Methoxy-6-chloro-9-diethylaminopentylaminoacridine, CHEMBL7568, H0C805XYDE, Mepacrine hydrochloride, CHEBI:8711, GNF-PF-5448, Quinacrine (hydrochloride,hydrate), Mepacrine (INN), chinacrin, Acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, MEPACRINE [INN], N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine, 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine, Atabrine hydrochloride dihydrate; Mepacrine hydrochloride, Mepacrina, Quinacrin, Mepacrine [INN:BAN], Mepacrinum [INN-Latin], Mepacrina [INN-Spanish], 6-CHLORO-N-[5-(DIETHYLAMINO)PENTAN-2-YL]-2-METHOXYACRIDIN-9-AMINE, N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine, N(4)-(6-chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine, Quinacrine, Mepacrine, HSDB 3253, EINECS 201-508-7, UNII-H0C805XYDE, Acirchine, 6-chloro-N-(5-(diethylamino)pentan-2-yl)-2-methoxyacridin-9-amine, AI3-04467, CCRIS 3726, CCRIS 8633, Acridine, 6-chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxy-, N~4~-(6-chloro-2-methoxyacridin-9-yl)-N~1~,N~1~-diethylpentane-1,4-diamine, Quinacrine,Mepacrine, Atebrin (Salt/Mix), Atebrine (Salt/Mix), Spectrum_000929, QUINACRINE [MI], Prestwick0_000318, Prestwick1_000318, Prestwick2_000318, Prestwick3_000318, Spectrum2_000888, Spectrum3_000606, Spectrum4_000496, Spectrum5_001405, (.+/-.)-Quinacrine, QUINACRINE [HSDB], QUINACRINE [VANDF], MEPACRINE [WHO-DD], Lopac0_000970, SCHEMBL19225, BSPBio_000316, BSPBio_002112, KBioGR_001011, KBioGR_002507, KBioSS_001409, KBioSS_002515, DivK1c_000101, SPBio_000676, SPBio_002535, BPBio1_000348, DTXSID7022627, GTPL10172, KBio1_000101, KBio2_001409, KBio2_002507, KBio2_003977, KBio2_005075, KBio2_006545, KBio2_007643, KBio3_001612, KBio3_002985, cMAP_000067, NINDS_000101, HMS2090L03, BBL028456, BDBM50015214, RP-866 (Dihydrochloride dihydrate), SN-390 (Dihydrochloride dihydrate), STL061087, AKOS000541535, AKOS016340229, CCG-205050, DB01103, MS-1557, SDCCGSBI-0050943.P006, IDI1_000101, N4-(6-Chloro-2-methoxy-acridin-9-yl)-N1,N1-diethyl-pentane-1,4-diamine, NCGC00015874-02, NCGC00015874-03, NCGC00015874-04, NCGC00015874-08, NCGC00015874-12, NCGC00162300-01, HY-13735, NCI60_000926, SBI-0050943.P004, AB00053540, CS-0007762, FT-0674264, FT-0778222, NS00003697, C07339, D08179, EN300-246511, AB00053540-08, AB00053540-09, AB00053540_10, Q417208, BRD-A45889380-300-04-8, BRD-A45889380-336-03-4, Z31251611, 2-Methoxy-6-chloro-9-diethylaminopent-2-ylaminoacridine, 6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-methylbutyl)amine, acridine, 3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)-, acridine, 3-chloro-9-(4-diethylamino-1-methyl)butylamino-7-methoxy-, N''-(6-chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine, N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylpentane-1,4-diamine, N4-(6-chloro-2-methoxy-acridin-9-yl)-N1,N1-diethyl-pentane-1,4-diamine, N'-(6-Chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine dihydrochloride, N4-(6-Chloro-2-methoxy-acridin-9-yl)-N1,N1-diethyl-pentane-1,4-diamine (Mepacrine), N~4~-[6-chloro-2-(methyloxy)acridin-9-yl]-N~1~,N~1~-diethylpentane-1,4-diamine, N4-(6-Chloro-2-methoxy-acridin-9-yl)-N1,N1-diethyl-pentane-1,4-diamine ; (mepacrine)
Drug Type	Small molecule
Formula	C₂₃H₃₀ClN₃O
SMILES	CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
InChI	1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
InChIKey	GPKJTRJOBQGKQK-UHFFFAOYSA-N
CAS Number	83-89-6
ChEMBL ID	CHEMBL7568
ChEBI ID	CHEBI:8711
Drug Bank ID	DB01103
KEGG ID	C07339
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Curcumin, Quinacrine
Partner Name	Curcumin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Down-regulation	Expression	ABCG2	hsa9429
	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	NOS3	hsa4846
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	SP	Healthy	Homo sapiens (Human)	CVCL_C4PJ
In Vivo Model	The tumor tissue was cut into small pieces. Then, a deep incision was made in the anterior region of Balb/C mice using a scissor and then 5-6 chopped tumor tissue pieces were implanted in the anterior peritoneal wall within 3 h of collecting tumor tissues from the patient.
Result	Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A