Pair Name	Morusin, TNF-related apoptosis inducing ligand
Phytochemical Name	Morusin
Anticancer drug Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	These results suggest that morusin enhances TRAIL sensitivity in human glioblastoma cells through regulating expression of DR5 and EGFR. Therefore, the combination treatment of TRAIL and morusin may be a new therapeutic strategy for malignant glioma patients.

Pair Name	20(s)-ginsenoside Rh2, TNF-related apoptosis inducing ligand
Phytochemical	20(s)-ginsenoside Rh2
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our study indicates that Rh2 may act as a sensitizer in combination with TRAIL to increase the efficacy of its anti-tumor activity.

Pair Name	Apigenin, TNF-related apoptosis inducing ligand
Phytochemical	Apigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A90]	Anaplastic large cell lymphoma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Apigenin breaks TRAIL resistance in HTLV-1-associated ATL by transcriptional down-regulation of c-FLIP, a key inhibitor of death receptor signaling, and by up-regulation of TRAIL receptor 2 (TRAIL-R2)

Pair Name	Apigenin, TNF-related apoptosis inducing ligand
Phytochemical	Apigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Apigenin enhances TRAIL-induced antitumor activity in NSCLC cells by APG via inhibition of the NF-kappaB, AKT and ERK prosurvival regulators

Pair Name	Apigenin, TNF-related apoptosis inducing ligand
Phytochemical	Apigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5

Pair Name	Bakuchiol, TNF-related apoptosis inducing ligand
Phytochemical	Bakuchiol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	The collective results suggest that bakuchiol facilitates TRAIL-induced apoptosis in colon cancer cells through up-regulation of the TRAIL receptors; DR4 and DR5 via ROS/JNK pathway signals.

Pair Name	Beta-Elemene, TNF-related apoptosis inducing ligand
Phytochemical	Beta-Elemene
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our results suggest that β-elemene increases the sensitivity of gastric cancer cells to TRAIL partially by promoting the formation of DISC in lipid rafts.

Pair Name	Bufalin, TNF-related apoptosis inducing ligand
Phytochemical	Bufalin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Bufalin enhanced TRAIL-induced apoptosis by up-regulating the expression of DR4 and DR5. Bufalin-induced down-regulation of Cbl-b contributed to the up-regulation of DR4 and DR5, which might be partially mediated by the activation of ERK, JNK and p38 MAPK.

Pair Name	Butein, TNF-related apoptosis inducing ligand
Phytochemical	Butein
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our data suggests that combined treatment with butein and TRAIL may provide a safe and effective strategy for treating cancer.

Pair Name	Cantharidin, TNF-related apoptosis inducing ligand
Phytochemical	Cantharidin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	The results of the present study revealed that cantharidin effectively sensitized cells to TRAIL‑mediated apoptosis and its effects are likely to be mediated by autophagy, the downregulation of c‑FLIP and the upregulation of DR‑5.

Pair Name	Capsaicin, TNF-related apoptosis inducing ligand
Phytochemical	Capsaicin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	A combined regimen using capsaicin and TRAIL may provide a safe and effective strategy for treating malignant gliomas.

Pair Name	Casticin, TNF-related apoptosis inducing ligand
Phytochemical	Casticin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Casticin enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-ER stress-CHOP pathway.

Pair Name	Chrysin, Cisplatin
Phytochemical	Chrysin
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our results suggest that combination of chrysin and cisplatin is a promising strategy for chemotherapy of human cancers that are resistant to cisplatin.

Pair Name	Curcumin, TNF-related apoptosis inducing ligand
Phytochemical	Curcumin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C17]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	The present study demonstrates the potential of using curcumin in combination with TRAIL to yield better TRAIL therapy outcomes in TRAIL-resistant CCA.

Pair Name	Decursin, TNF-related apoptosis inducing ligand
Phytochemical	Decursin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	ROS generation by decursin selectively activated the PERK/ATF4 axis of the endoplasmic reticulum stress signalling pathway, leading to enhanced TRAIL sensitivity in TRAIL-resistant NSCLC cell lines, partly via up-regulation of DR5.

Pair Name	Epigallocatechin gallate, TNF-related apoptosis inducing ligand
Phytochemical	Epigallocatechin gallate
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Activation of autophagic flux by epigallocatechin gallate mitigates TRAIL-induced tumor cell apoptosis via down-regulation of death receptors

Pair Name	Fisetin, Sorafenib
Phytochemical	Fisetin
Drug	Sorafenib
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	The combination of fisetin and sorafenib exerted better synergistic effects in vitro and in vivo than either agent used alone against human cervical cancer, and this synergism was based on apoptotic potential through a mitochondrial- and DR5-dependent caspase-8/caspase-3 signaling pathway

Pair Name	Gomisin N, TNF-related apoptosis inducing ligand
Phytochemical	Gomisin N
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our results indicated that gomisin N was able to potentiate TRAIL-induced apoptosis through ROS-mediated up-regulation of DR4 and DR5.

Pair Name	Homoharringtonine, Suberoylanilide hydroxamic acid (SAHA)
Phytochemical	Homoharringtonine
Drug	Suberoylanilide hydroxamic acid (SAHA)
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	The synergistic effect between HHT and SAHA was blocked partially using a specific anti‑TRAIL antibody. The combination therapy was also found to significantly inhibit the growth of leukemia xenografts in vivo with enhanced apoptosis. These results indicate that, by regulating the induction of TRAIL and activation of the TRAIL apoptotic pathway, it is possible to administer HHT at low concentrations in combination with SAHA as an effective therapeutic approach for the treatment of AML.

Pair Name	Irigenin, TNF-related apoptosis inducing ligand
Phytochemical	Irigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our present study gave new insights into the effects of Iri on potentiating TRAIL-sensitivity, and suggested that Iri could be a potential candidate for sensitizer of TRAIL-resistant cancer cell treatment.

Pair Name	Isoliquiritigenin, TNF-related apoptosis inducing ligand
Phytochemical	Isoliquiritigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Isoliquiritigenin has the potential to overcome resistance to TRAIL in cancer cells and its chemopreventive effects may depend on TRAIL function

Pair Name	Isoquercitrin, TNF-related apoptosis inducing ligand
Phytochemical	Isoquercitrin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	We found that isoquercitrin enhances the mRNA expression of TRAIL-Rs, but the percentage of apoptosis was meager, possibly due to the influence of other anti-apoptotic proteins.

Pair Name	Kaempferol, TNF-related apoptosis inducing ligand
Phytochemical	Kaempferol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	It is reasonable to conclude that sensitization of chronic leukemia cells to TRAIL by kaempferol in vitro should be considered as a way of focusing clinical attention on leukemia therapy.

Pair Name	Kaempferol, TNF-related apoptosis inducing ligand
Phytochemical	Kaempferol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	The co-treatment induced no apoptosis in normal human peripheral blood mononuclear cells and little apoptosis in normal human hepatocytes. These results suggest that kaempferol is useful for TRAIL-based treatments for cancer.

Pair Name	Licochalcone B, TNF-related apoptosis inducing ligand
Phytochemical	Licochalcone B
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	LCB exhibits cytotoxic activity through modulation of the Akt/mTOR, ER stress and MAPK pathways in HCC cells and effectively enhances TRAIL sensitivity through the upregulation of DR5 expression in ERK- and JNK-dependent manner. Combination therapy with LCB and TRAIL may be an alternative treatment strategy for HCC.

Pair Name	Liquiritin, TNF-related apoptosis inducing ligand
Phytochemical	Liquiritin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Combining TRAIL and liquiritin exerts synergistic effects against human gastric cancer cells and xenograft in nude mice through potentiating apoptosis and ROS generation

Pair Name	Luteolin, TNF-related apoptosis inducing ligand
Phytochemical	Luteolin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	TRAIL combined with luteolin could be as an effective chemotherapeutic strategy for NSCLC.

Pair Name	Medicarpin, TNF-related apoptosis inducing ligand
Phytochemical	Medicarpin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B33.1]	Myeloid leukemia		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

Pair Name	Morin, Auranofin
Phytochemical	Morin
Drug	Auranofin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	This study provides evidence that morin can enhance the anticancer activity of AF in Hep3B human hepatocellular carcinoma cells, indicating that its combination could be an alternative treatment strategy for the hepatocellular carcinoma.

Pair Name	Naringenin, AMG-951
Phytochemical	Naringenin
Drug	AMG-951
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	The present study provides a novel therapeutic strategy for glioma by potentiating APO2L-induced apoptosis via the combination with NG in glioma tumor cells.

Pair Name	Neobavaisoflavone, TNF-related apoptosis inducing ligand
Phytochemical	Neobavaisoflavone
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Taken together, our results suggest that NBIF reduces the resistance of cancer cells to TRAIL and that the combination of NBIF and TRAIL may be a new therapeutic strategy for treating TRAIL-resistant glioma cells.

Pair Name	Nimbolide, Tumor necrosis factor-alpha
Phytochemical	Nimbolide
Drug	Tumor necrosis factor-alpha
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our findings overall indicate that nimbolide may enhance TNF-α-mediated cellular proliferation inhibition through increasing cell apoptosis of HT-29 cells by up-reglation of DR5 expression via the JNK pathway.

Pair Name	Oleuropein, Cisplatin
Phytochemical	Oleuropein
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	These data revealed that oleuropein regulated the expression of the above-mentioned miRNAs in ovarian cancer cells, which potentially resulted in apoptosis induction, cell proliferation inhibition, and cisplatin resistance decline in ovarian cancer cells. To confirm the results of this study, it is suggested that similar experiments be performed in animal models of ovarian cancer.

Pair Name	Periplocin, TNF-related apoptosis inducing ligand
Phytochemical	Periplocin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Antitumor Effect of Periplocin in TRAIL-Resistant gastric cancer cells via upregulation of death receptor through activating ERK1/2-EGR1 pathway

Pair Name	Periplocin, TNF-related apoptosis inducing ligand
Phytochemical	Periplocin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B70.1]	Esophageal squamous cell carcinoma		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our data suggest that CPP and TRAIL could be further explored as potential therapeutic approach for esophageal cancer.

Pair Name	Plumbagin, rsTRAIL
Phytochemical	Plumbagin
Drug	rsTRAIL
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our results suggest that both plumbagin and rsTRAIL could be used as a single agent or synergistical agents to induce apoptosis of leukemic Kasumi‑1 cells in vitro and in vivo.

Pair Name	Pterostilbene, TNF-related apoptosis inducing ligand
Phytochemical	Pterostilbene
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Pterostilbene enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistance triple negative breast cancer cells

Pair Name	Shogaol, Gefitinib
Phytochemical	Shogaol
Drug	Gefitinib
Disease Info	[ICD-11: 2C73]	Ovarian Cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our results suggest that 6-shogaol exerts a potential anti-cancer effect in ovarian cancer and combination treatment with 6-shogaol and gefitinib may provide a novel anti-tumor therapeutic strategy in gefitinib-resistant ovarian cancer.

Pair Name	Tanshinone IIA, TNF-related apoptosis inducing ligand
Phytochemical	Tanshinone IIA
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	T-IIA increases TRAIL-induced apoptosis by downregulating STAT3 and upregulating DR4 and DR5, indicating T-IIA therapy as a novel treatment strategy for TRAIL-resistant GBM.

Pair Name	Thymoquinone, TNF-related apoptosis inducing ligand
Phytochemical	Thymoquinone
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	The synergistic influence between TQ which induced the DR5 and TRAIL, facilitating the connection between TRAIL and its receptors on the cancerous cell membrane. Hence, the proposed combination therapy induced the ROS-mediated apoptotic stimulus.

Pair Name	Zerumbone, Celecoxib
Phytochemical	Zerumbone
Drug	Celecoxib
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	Our results provide novel insights into the role of ATF3 as an essential transcription factor for p53-independent DR5 induction upon both ZER and CCB treatment, and this may be a useful biomarker for TRAIL-based anticancer therapy.

Pair Name	Shogaol, TNF-related apoptosis inducing ligand
Phytochemical	Shogaol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Tumor necrosis factor receptor superfamily member 10B		Expression
Result	This study gives rise to the possibility of applying shogaol as an antitumor agent that can be used for the purpose of combination treatment with TRAIL in TRAIL-resistant colon tumor therapy.