Pair Name	Artesunate, Fluorouracil
Phytochemical Name	Artesunate
Anticancer drug Name	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	Our findings point to the crucial treatment effect of Arte on inflammation, intestinal cell senescence, and CRC cell proliferation and offer a new option for CRC treatment.

Pair Name	Ononin, Paclitaxel
Phytochemical Name	Ononin
Anticancer drug Name	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Our findings suggested that the therapeutic index of PTX-based chemotherapy could be improved by reducing toxicity with increasing antitumor capabilities when combined with ononin.

Pair Name	Amentoflavone, Cisplatin
Phytochemical	Amentoflavone
Drug	Cisplatin
Disease Info	[ICD-11: 2B66.0]	Oral squamous cell carcinoma		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Activity
Result	Inactivation of NF-κB and induction of apoptosis through intrinsic caspase-dependent and independent apoptotic pathways are associated with amentoflavone enhanced anti-OSCC efficacy of cisplatin.

Pair Name	Artepillin C, TNF-related apoptosis inducing ligand
Phytochemical	Artepillin C
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Transcription factor p65		Activity
Result	The data demonstrate the important role of Brazilian green propolis and its bioactive compounds in prostate cancer chemoprevention through the enhancement of TRAIL-mediated apoptosis.

Pair Name	Astragaloside IV, Carboplatin
Phytochemical	Astragaloside IV
Drug	Carboplatin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	Our results suggested that AgIV enhanced carboplatin sensitivity in prostate cancer cell lines by suppressing AKT/NF-κB signaling, thus suppressed epithelial-mesenchymal transition induced by carboplatin. Our findings provided a new mechanism for AgIV in overcoming drug resistance of platinum-based chemotherapy and suggested a potential combination therapy of AgIV and carboplatin in prostate cancer.

Pair Name	Baicalein, Cisplatin
Phytochemical	Baicalein
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Baicalein enhanced cisplatin sensitivity of gastric cancer cells by inducing cell apoptosis and autophagy via Akt/mTOR and Nrf2/Keap 1 pathway

Pair Name	Bergamottin, Simvastatin
Phytochemical	Bergamottin
Drug	Simvastatin
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Regulate Info	Up-regulation	Transcription factor p65		Expression
Result	Discussion and conclusion Our results provide novel insight into the role of SV and BGM in potentially preventing and treating cancer through modulation of NF-κB signalling pathway and its regulated gene products.

Pair Name	Beta-Elemene, Bortezomib
Phytochemical	Beta-Elemene
Drug	Bortezomib
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism

Pair Name	Beta-Elemene, Fluorouracil
Phytochemical	Beta-Elemene
Drug	Fluorouracil
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	The conclusion obtained, considering that the results suggest that the combination may be important specifically in the treatment of TNBC.

Pair Name	Crocin, Sorafenib
Phytochemical	Crocin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	CR potentiates the suppressive effects of SB on tumor growth and provides the opportunity to strengthen the therapeutic effects of SB in the treatment of HCC.

Pair Name	Curcumin, Paclitaxel
Phytochemical	Curcumin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Curcumin reduces paclitaxel resistance in ovarian carcinoma cells by upregulating SNIP1 and inhibiting NFκB activity

Pair Name	Curcumin, Pyridoxine
Phytochemical	Curcumin
Drug	Pyridoxine
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	C + B is superior to either agent alone in preventing obesity-promoted colorectal carcinogenesis. Augmented suppression of procancerous signaling pathways may be the means by which this augmentation occurs.

Pair Name	Curcumol, Cisplatin
Phytochemical	Curcumol
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	The findings may offer new thoughts that curcumol in combination with cisplatin might be a useful strategy for GC management.

Pair Name	Eugenol, Cisplatin
Phytochemical	Eugenol
Drug	Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	These results provide strong preclinical justification for combining cisplatin with eugenol as therapeutic approach for triple-negative breast cancers through targeting the resistant ALDH-positive cells and inhibiting the NF-κB pathway.

Pair Name	Evodiamine, Gemcitabine
Phytochemical	Evodiamine
Drug	Gemcitabine
Disease Info	[ICD-11: 2B62.Z]	Tongue cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	The results of this study showed that EVO may inhibit cancer cells by suppressing NF-κB activity, and in combination with GEM, it may increase the chemosensitivity of tongue squamous cancer cells, thereby improving the treatment response.

Pair Name	Fucoxanthin, TNF-related apoptosis inducing ligand
Phytochemical	Fucoxanthin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	We found that fucoxanthin- or TRAIL-induced apoptosis of human cervical cancer cells was obviously down-regulated. CONCLUSIONS Taken together, these findings suggest that fucoxanthin and TRAIL increased the apoptosis in human cervical cancer cells by targeting the PI3K/Akt/NF-κB signaling pathway.

Pair Name	Gambogic Acid, Cisplatin
Phytochemical	Gambogic Acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Transcription factor p65		Expression
Result	Gambogic acid sensitises lung cancer cells to CDDP in vitro and in vivo in NSCLC through inactivation of NF-κB and MAPK/HO-1 signalling pathways, providing a rationale for the combined use of CDDP and GA in lung cancer chemotherapy.

Pair Name	Gambogic Acid, Doxorubicin
Phytochemical	Gambogic Acid
Drug	Doxorubicin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Transcription factor p65		Expression
Result	These findings indicate that GA sensitizes lung cancer cells to ADM in vitro and in vivo, providing a rationale for the combined use of GA and ADM in lung cancer chemotherapy.

Pair Name	Gamma-Tocotrienol, Capecitabine
Phytochemical	Gamma-Tocotrienol
Drug	Capecitabine
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Our results show that γ-tocotrienol can potentiate the effects of capecitabine through suppression of NF-κB-regulated markers of proliferation, invasion, angiogenesis, and metastasis.

Pair Name	Gamma-Tocotrienol, Docetaxel
Phytochemical	Gamma-Tocotrienol
Drug	Docetaxel
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	These findings suggest that the combination treatment with these agents may provide enhanced therapeutic response in oral cancer patients, while avoiding the toxicity associated with high-dose β-tubulin stabilization monotherapy.

Pair Name	Garcinol, Paclitaxel
Phytochemical	Garcinol
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model

Pair Name	Glucosinalbate, Doxorubicin
Phytochemical	Glucosinalbate
Drug	Doxorubicin
Disease Info	[ICD-11: 2C90]	Ehrlich ascites carcinoma		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	The present study clearly suggested therapeutic benefit of I3C in combination with DOX by augmenting anticancer efficacy and diminishing toxicity to the host.

Pair Name	Helichrysetin, Tumor necrosis factor-alpha
Phytochemical	Helichrysetin
Drug	Tumor necrosis factor-alpha
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	Helichrysetin and TNF‑α synergistically promoted apoptosis by inhibiting TAK1/IKK/NF‑κB and TAK1/EGFR signaling pathways in HeLa and T98G cells, indicating a potential therapeutic strategy for cancer.

Pair Name	Honokiol, Oxaliplatin
Phytochemical	Honokiol
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	This combination allows a reduction in oxaliplatin dose, and thereby reduces its adverse effects. It may also enhance the chemotherapeutic effect of oxaliplatin for this disease.

Pair Name	Hyperoside, Paclitaxel
Phytochemical	Hyperoside
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Hyperoside may elevate breast cancer cell sensitivity to paclitaxel by blocking TLR4 activation-mediated pro-inflammatory and pro-survival approaches, thereby endorsing its usefulness as a promising therapeutic combination to overcome chemosensitivity in breast cancer.

Pair Name	Icaritin, TNF-related apoptosis inducing ligand
Phytochemical	Icaritin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	These data suggest that icaritin sensitizes TRAIL-induced tumor cell apoptosis via suppression of NF-κB-dependent c-FLIP expression, providing in vitro evidence supporting the notion that icaritin is a potential sensitizer of TRAIL in anticancer therapy against human GBM.

Pair Name	lambda-Carrageenan Oligosaccharides, Fluorouracil
Phytochemical	lambda-Carrageenan Oligosaccharides
Drug	Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	These findings suggested that λ-COS could be used as an immune-modulating agent for chemotherapy.

Pair Name	Lycorine, Temozolomide
Phytochemical	Lycorine
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	Our study suggested that lycorine exerts an anti-glioma effect by inducing ROS production and inhibiting NF-κB, which validated that lycorine may be a potential candidate for glioma treatment alone or in combination with TMZ.

Pair Name	Myriocin, Cisplatin
Phytochemical	Myriocin
Drug	Cisplatin
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	We suggest that myriocin is a novel potent anti-cancer agent that dually targets both VEGFR2 in ECs and IκBα in cancer cells, and exerts more pronounced anti-tumor effects than with either kinase being inhibited alone.

Pair Name	Norizalpinin, Cisplatin
Phytochemical	Norizalpinin
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Our data indicated a novel therapeutic strategy to potentiate DDP-induced anti-tumor effect in lung cancer cells with DDP resistance by GG through inactivating p-STAT3/p65 and Bcl-2 pathways.

Pair Name	Periplocin, Gemcitabine
Phytochemical	Periplocin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells

Pair Name	Polyphyllin I, Enzalutamide
Phytochemical	Polyphyllin I
Drug	Enzalutamide
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Our results indicate that PPI inhibits the growth of CRPC cells by inhibiting p65 protein and concomitantly reducing HOTAIR expression, thereby suppressing MUC1 gene expression. The novel regulatory interaction of p65 and HOTAIR converge in the inhibition of MUC1 expression and overall PPI response. The combination of PPI and enzalutamide exhibits synergy. This study reveals a novel mechanism underlying the synergistic inhibitory effect of PPI and enzalutamide on the growth of CRPC cells.

Pair Name	Propyl gallate, Temozolomide
Phytochemical	Propyl gallate
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κ B Pathway

Pair Name	Quercetin, Anti-PD-1 antibody
Phytochemical	Quercetin
Drug	Anti-PD-1 antibody
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Quercetin/anti-PD-1 antibody combination therapy reshaped HCC tumor microenvironment in mice in parallel with regulating the GM and macrophage immunity.

Pair Name	Shogaol, Gemcitabine
Phytochemical	Shogaol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10.0]	Pancreatic ductal adenocarcinoma		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	Our results suggest that 6-shogaol can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing of TLR4/NF-κB-mediated inflammatory pathways linked to tumorigenesis.

Pair Name	Sulforaphane, CB-5083
Phytochemical	Sulforaphane
Drug	CB-5083
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Transcription factor p65		Expression
Result	The combination of Sulforaphane and CB-5083 may be a useful treatment strategy to combat CB-5083 resistance.

Pair Name	Tectochrysin, Cetuximab
Phytochemical	Tectochrysin
Drug	Cetuximab
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Our results indicate that combined therapy with lower concentration of cetuximab and tectochrysin could significantly enhance the cancer cell growth inhibitory effect through the inhibition of EGFR signaling.

Pair Name	Thymoquinone, Bortezomib
Phytochemical	Thymoquinone
Drug	Bortezomib
Disease Info	[ICD-11: 2A85.5]	Mantle cell lymphoma		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-KappaB regulated gene products in multiple myeloma xenograft mouse model

Pair Name	Tubeimoside I, Temozolomide
Phytochemical	Tubeimoside I
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	We first demonstrated that synergistic effects of TBMS1 and TMZ induced apoptosis in GBM cells through reducing MGMT expression and inhibiting the EGFR induced PI3K/Akt/mTOR/NF-κB signaling pathway. This study provides a rationale for combined application of TMZ and TBMS1 as a potential chemotherapeutic treatment for MGMT+ GBM patients.

Pair Name	Ursolic acid, Cisplatin
Phytochemical	Ursolic acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	The combination of UA with DDP could more effectively inhibit SiHa cells proliferation and facilitate cell apoptosis through suppressing NF-κB p65.

Pair Name	Voacamine, Paclitaxel
Phytochemical	Voacamine
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Our data show the specific effect of VOA which only works on drugs known to be substrates of P-gp.

Pair Name	Oxymatrine, Fluorouracil
Phytochemical	Oxymatrine
Drug	Fluorouracil
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Phosphorylation
Result	Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-kappa B signaling in vitro

Pair Name	Sulforaphane, Temozolomide
Phytochemical	Sulforaphane
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	The present study suggests that the clinical efficacy of TMZ-based chemotherapy in TMZ-resistant GBM may be improved by combination with SFN.

Pair Name	Troxerutin, Fluorouracil
Phytochemical	Troxerutin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Transcription factor p65		Expression
Result	Our data indicated a novel therapeutic strategy to potentiate 5-FU-induced anti-tumor effect in gastric cancer cells with resistance to 5-FU by TXN through suppression of p-STAT3/NF-κB (p65 and p50) and Bcl-2.