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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name Signal transducer CD24
UniProt ID CD24_HUMAN
Gene Name CD24
Gene ID 100133941
Synonyms
CD24, CD24A
Sequence
MGRAMVARLGLGLLLLALLLPTQIYSSETTTGTSSNSSQSTSNSGLAPNPTNATTKAAGG
ALQSTASLFVVSLSLLHLYS
Pathway Map MAP LINK
T.C. Number 8.A.128.7.1
KEGG ID hsa100133941
TTD ID T65906
Pfam PF06679; PF14984
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Reversing Drug Resistance
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Combination Pair ID: 820
Pair Name Curcumin, Irinotecan
Phytochemical Curcumin
Drug Irinotecan
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Regulate Info Down-regulation Signal transducer CD24 Expression
Result The present data demonstrated that curcumin attenuated resistance to chemotherapeutic drugs through induction of apoptosis of CSCs among colon cancer cells. These findings may provide novel evidence for the therapeutic application of curcumin in CRC intervention.
03. Reference
No. Title Href
1 Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells. Int J Oncol. 2018 Sep;53(3):1343-1353. doi: 10.3892/ijo.2018.4461. Click
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