Pair Name	Isovitexin, Cisplatin
Phytochemical Name	Isovitexin
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	IVT not only inhibited cell proliferation and glucose metabolism via downregulating the expression of PKM2 to enhance the antitumor activity of DDP against lung cancer cells, and improved DDP-induced immunotoxicity in mice. It also presented a novel strategy to enhance the anti-tumor effect of platinum-based chemotherapy against NSCLC.

Pair Name	(S)-10-Hydroxycamptothecin, Crizotinib
Phytochemical	(S)-10-Hydroxycamptothecin
Drug	Crizotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

Pair Name	AKBA, Cisplatin
Phytochemical	AKBA
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Acetyl-11-keto-beta-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway

Pair Name	Amygdalin, Cisplatin
Phytochemical	Amygdalin
Drug	Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Bcl-2-like protein 1		Expression
Result	Our present findings suggest that amygdalin has chemo-modulatory effect when used in co-treatment with cisplatin and is able to protect normal breast cells as well as the fibroblasts during chemotherapy treatment, indicating a strong selective chemoprotective ability and may contribute to a better quality of life for cancer patients.

Pair Name	Apigenin, Doxorubicin
Phytochemical	Apigenin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Co-administration of apigenin with doxorubicin enhances anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells

Pair Name	Apigenin, TNF-related apoptosis inducing ligand
Phytochemical	Apigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Apigenin enhances TRAIL-induced antitumor activity in NSCLC cells by APG via inhibition of the NF-kappaB, AKT and ERK prosurvival regulators

Pair Name	Astaxanthin, Cytarabine
Phytochemical	Astaxanthin
Drug	Cytarabine
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Co-treatment of ASX and Ara-C has synergism effects on apoptosis pathways, cell proliferation inhibition, and decreased inflammation.

Pair Name	Bergamottin, Simvastatin
Phytochemical	Bergamottin
Drug	Simvastatin
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Discussion and conclusion Our results provide novel insight into the role of SV and BGM in potentially preventing and treating cancer through modulation of NF-κB signalling pathway and its regulated gene products.

Pair Name	Beta-Elemene, Cisplatin
Phytochemical	Beta-Elemene
Drug	Cisplatin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	β-elemene enhancement of cisplatin-induced apoptosis via mitochondrial activation of the caspase-mediated apoptotic pathway may account for the augmented anti-cancer potency of cisplatin in prostate cancer. Cisplatin combined with β-elemene as a chemosensitizer or adjuvant warrants further study and may be potentially useful as a first-line treatment of androgen-independent prostate carcinomas.

Pair Name	Beta-Elemene, Cisplatin
Phytochemical	Beta-Elemene
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	These data indicate that β-elemene sensitizes chemoresistant ovarian carcinoma cells to cisplatin-induced apoptosis and that the augmented effect of β-elemene on cisplatin cytotoxicity and sensitivity in resistant ovarian tumor cells is mediated through a mitochondria- and caspase-dependent cell death pathway.

Pair Name	Betulinic Acid, Sorafenib
Phytochemical	Betulinic Acid
Drug	Sorafenib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	We showed that combination therapy with low concentrations of sorafenib and betulinic acid had the capacity to induce high levels of cell death and abolish clonogenic activity in some NSCLC cell lines regardless of KRAS mutations.

Pair Name	Bufalin, Hydroxycamptothecin
Phytochemical	Bufalin
Drug	Hydroxycamptothecin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The present study suggested that the combination of bufalin and hydroxycampothecin improved the inhibitory effects of both drugs on CRPC tumors in vivo, potentially via the regulation of the PI3K/AKT/GSK-3β and p53-dependent apoptosis signaling pathways.

Pair Name	Carnosic acid, Tamoxifen
Phytochemical	Carnosic acid
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our study supplies a novel therapeutic strategy to induce apoptosis for suppressing breast cancer, which was relied on Caspase-3/TRAIL activation.

Pair Name	Casticin, TNF-related apoptosis inducing ligand
Phytochemical	Casticin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Casticin enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-ER stress-CHOP pathway.

Pair Name	Chlorogenic acid, Regorafenib
Phytochemical	Chlorogenic acid
Drug	Regorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	This drug combination could be considered as a safe and more effective approach in HCC therapy.

Pair Name	Curcumin, Thalidomide
Phytochemical	Curcumin
Drug	Thalidomide
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our findings suggested that down-regulation of STAT3 and BCL-XL mRNA expression in response to CUR and THAL treatment lead to inhibition of cell growth and induction of apoptosis.

Pair Name	Epigallocatechin gallate, TNF-related apoptosis inducing ligand
Phytochemical	Epigallocatechin gallate
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B6B]	Nasopharyngeal carcinoma		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	EGCG sensitizes NPC cells to TRAIL-mediated apoptosis via modulation of extrinsic and intrinsic apoptotic pathways and inhibition of NF-κB activation.

Pair Name	Evodiamine, Gemcitabine
Phytochemical	Evodiamine
Drug	Gemcitabine
Disease Info	[ICD-11: 2B62.Z]	Tongue cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The results of this study showed that EVO may inhibit cancer cells by suppressing NF-κB activity, and in combination with GEM, it may increase the chemosensitivity of tongue squamous cancer cells, thereby improving the treatment response.

Pair Name	Flavokawain A, Herceptin
Phytochemical	Flavokawain A
Drug	Herceptin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our results suggest FKA as a promising and novel apoptosis inducer and G2 blocking agent that, in combination with Herceptin, enhances for the treatment of HER2-overexpressing breast cancer.

Pair Name	Gambogic Acid, Doxorubicin
Phytochemical	Gambogic Acid
Drug	Doxorubicin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	These findings indicate that GA sensitizes lung cancer cells to ADM in vitro and in vivo, providing a rationale for the combined use of GA and ADM in lung cancer chemotherapy.

Pair Name	Gambogic Acid, TNF-related apoptosis inducing ligand
Phytochemical	Gambogic Acid
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	These findings may open a new window in the treatment of breast cancer using TRAIL in combination with GA.

Pair Name	Gamma-Tocotrienol, Capecitabine
Phytochemical	Gamma-Tocotrienol
Drug	Capecitabine
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our results show that γ-tocotrienol can potentiate the effects of capecitabine through suppression of NF-κB-regulated markers of proliferation, invasion, angiogenesis, and metastasis.

Pair Name	Gamma-Tocotrienol, Gemcitabine
Phytochemical	Gamma-Tocotrienol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our findings suggest that γ-T3 can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing NF-κB-mediated inflammatory pathways linked to tumorigenesis.

Pair Name	Ginsenoside Rg5, Paclitaxel
Phytochemical	Ginsenoside Rg5
Drug	Paclitaxel
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Ginsenoside Rg5 Sensitizes Paclitaxel-Resistant Human Cervical-Adeno-Carcinoma Cells to Paclitaxel-And Enhances the Anticancer Effect of Paclitaxel

Pair Name	Gossypol, Gefitinib
Phytochemical	Gossypol
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations.

Pair Name	Gossypol, Idarubicin
Phytochemical	Gossypol
Drug	Idarubicin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	These findings suggest that combinatorial therapy with AT-101 and IDA selectively eliminates leukemia stem-like cells both in vitro and in vivo, representing a potent and alternative salvage therapy for the treatment of relapsed and refractory patients with AML.

Pair Name	Gossypol, Imatinib
Phytochemical	Gossypol
Drug	Imatinib
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	These results suggest that (-)gossypol induced apoptosis in K562 cells through a mitochondria pathway and that the combination of imatinib and (-)gossypol might be an effective treatment for CML.

Pair Name	Honokiol, Cabozantinib
Phytochemical	Honokiol
Drug	Cabozantinib
Disease Info	[ICD-11: 2C90.0]	Renal cell carcinoma		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Cabozantinib + Honokiol combination can significantly inhibit c-Met-induced and Nrf2-mediated anti-oxidant pathway in renal cancer cells to promote increased oxidative stress and tumor cell death.

Pair Name	Icariin, Fluorouracil
Phytochemical	Icariin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	We suggest that combination of icariin with 5-FU might offer a therapeutic benefit to the patients with CRC; however, further studies are required to ascertain this proposition.

Pair Name	Icariin, Gemcitabine
Phytochemical	Icariin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C94]	Bladder cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Icariin, by suppressing NF-κB activity, exerts antitumor activity, and potentiates the antitumor activity of gemcitabine in gallbladder cancer. Combined administration of gemcitabine and icariin may offer a better therapeutic option for the patients with gallbladder cancer.

Pair Name	Isoliquiritigenin, TNF-related apoptosis inducing ligand
Phytochemical	Isoliquiritigenin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Isoliquiritigenin has the potential to overcome resistance to TRAIL in cancer cells and its chemopreventive effects may depend on TRAIL function

Pair Name	Luteolin, Erlotinib
Phytochemical	Luteolin
Drug	Erlotinib
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	These findings suggest that combining luteolin with erlotinib offers a potential treatment strategy for glioblastoma multiforme IV.

Pair Name	Luteolin, SMC3
Phytochemical	Luteolin
Drug	SMC3
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The results suggest that combination of SMC3 and luteolin is an effective approach for improving the anticancer value of SMC3, which has implications in cancer prevention and therapy.

Pair Name	Mangiferin, Doxorubicin
Phytochemical	Mangiferin
Drug	Doxorubicin
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our findings suggest that the combination of mangiferin and an anticancer drug could be used as a new regime for the treatment of MM.

Pair Name	Medicarpin, TNF-related apoptosis inducing ligand
Phytochemical	Medicarpin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B33.1]	Myeloid leukemia		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

Pair Name	Nobiletin, Vorinostat
Phytochemical	Nobiletin
Drug	Vorinostat
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The combination of nobiletin with vorinostat increased histone H3K9 and H3K27 acetylation levels in SCLC mouse tumor tissue and enhanced the expression of the BH3-only proteins BIM and BID. We conclude that nobiletin is a novel natural BH3 mimetic that can cooperate with vorinostat to induce apoptosis and autophagy in SCLC.

Pair Name	Oridonin, Venetoclax
Phytochemical	Oridonin
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Oridonin and venetoclax synergistically promote AML cell apoptosis by inhibiting AKT signaling.

Pair Name	OSW-1, Carboplatin
Phytochemical	OSW-1
Drug	Carboplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our data revealed the mode of action and molecular mechanism underlying the effect of OSW-1 against TNBC, and provided a useful guidance for improving the sensitivity of TNBC cells to conventional chemotherapeutic drugs, which warrants further investigation.

Pair Name	Oxymatrine, Paclitaxel
Phytochemical	Oxymatrine
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model

Pair Name	Parthenolide, Balsalazide
Phytochemical	Parthenolide
Drug	Balsalazide
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	These results demonstrate that parthenolide potentiates the efficacy of balsalazide through synergistic inhibition of NF-κB activation and the combination of dual agents prevents colon carcinogenesis from chronic inflammation.

Pair Name	Periplocin, Gemcitabine
Phytochemical	Periplocin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells

Pair Name	Platycodin D, Venetoclax
Phytochemical	Platycodin D
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Bcl-2-like protein 1		Expression
Result	Platycodin D may be a potent therapeutic candidate for the treatment of AML

Pair Name	Pterostilbene, TNF-related apoptosis inducing ligand
Phytochemical	Pterostilbene
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Pterostilbene enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistance triple negative breast cancer cells

Pair Name	Resveratrol, Olaparib
Phytochemical	Resveratrol
Drug	Olaparib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	RES + OLA combination treatment enhanced breast cancer cell death by causing excessive DNA damage and also simultaneously inhibiting the HR pathway.

Pair Name	Resveratrol, Rapamycin
Phytochemical	Resveratrol
Drug	Rapamycin
Disease Info	[ICD-11: 2D10.1]	Papillary thyroid cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The present study suggests that the combination of rapamycin and resveratrol may be a promising strategy for the treatment of papillary thyroid cancer.

Pair Name	Rosmarinic acid, Anti-MUC1 antibody
Phytochemical	Rosmarinic acid
Drug	Anti-MUC1 antibody
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Results of the study indicate that combined action of anti-MUC1 and RA is more effective than monotherapy in relation to examined cancer related factors. Such treatment can be considered as new, promising strategy in gastric cancer therapy.

Pair Name	Sanguinarium, Bortezomib
Phytochemical	Sanguinarium
Drug	Bortezomib
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our findings demonstrate that SNG induces mitochondrial and caspase-dependent apoptosis, generates oxidative stress, and suppresses MM cell lines proliferation. In addition, co-treatment of MM cell lines with sub-toxic doses of SNG and BTZ potentiated the cytotoxic activity. These results would suggest that SNG could be developed into therapeutic agent either alone or in combination with other anticancer drugs in MM.

Pair Name	Shikonin, Gemcitabine
Phytochemical	Shikonin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our results suggest that shikonin can suppress the growth of human pancreatic tumors and potentiate the antitumor effects of gemcitabine through the suppression of NF-κB and NF-κB-regulated gene products.

Pair Name	Shikonin, TNF-related apoptosis inducing ligand
Phytochemical	Shikonin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The results indicated that shikonin sensitized resistant cancer cells to TRAIL-induced cytotoxicity via the modulation of the JNK, STAT3 and AKT pathways, the downregulation of antiapoptotic proteins and the upregulation of proapoptotic proteins.

Pair Name	Silibinin, Trichostatin A
Phytochemical	Silibinin
Drug	Trichostatin A
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Combinations of TSA with silibinin synergistically augmented the cytotoxic effects of the single agent, which was associated with a dramatic increase in p21 (Cdkn1a)

Pair Name	Sulforaphane, CB-5083
Phytochemical	Sulforaphane
Drug	CB-5083
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The combination of Sulforaphane and CB-5083 may be a useful treatment strategy to combat CB-5083 resistance.

Pair Name	Sulforaphane, TNF-related apoptosis inducing ligand
Phytochemical	Sulforaphane
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The ability of sulforaphane to inhibit tumor growth, metastasis, and angiogenesis and to enhance the therapeutic potential of TRAIL suggests that sulforaphane alone or in combination with TRAIL can be used for the management of prostate cancer.

Pair Name	Tectorigenin, Paclitaxel
Phytochemical	Tectorigenin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	These data suggest that tectorigenin could sensitize paclitaxel-resistant human ovarian cancer cells through inactivation of the Akt/IKK/IκB/NFκB signaling pathway, and promise a new intervention to chemosensitize paclitaxel-induced cytotoxicity in ovarian cancer.

Pair Name	Tetrandrine, Sorafenib
Phytochemical	Tetrandrine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The antitumour activity of sorafenib plus tetrandrine may be attributed to the induction of the intrinsic apoptosis pathway through ROS/Akt signaling. This finding provides a novel approach that may broaden the clinical application of sorafenib.

Pair Name	Fisetin, Paclitaxel
Phytochemical	Fisetin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Our study shows that PTX-FA and Fis-FA PBM NPs directly target platinum-resistant OvCa cells, induce cytotoxic/apoptotic effects, and reverse multi-drug resistance (MDR). These findings allow us to create new clinical applications using PTX-FA and Fis-FA combination nanoparticles to treat drug-resistant cancers.

Pair Name	Gamma-Tocotrienol, Simvastatin
Phytochemical	Gamma-Tocotrienol
Drug	Simvastatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol

Pair Name	Gossypol, Gemcitabine
Phytochemical	Gossypol
Drug	Gemcitabine
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression

Pair Name	Mitocurcumin, Cytarabine
Phytochemical	Mitocurcumin
Drug	Cytarabine
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	The data suggest that MitoC exploits stress-induced leukemic oxidative environment to up-regulate JNK/p38 signaling to lead to apoptosis and can potentially overcome Cytarabine resistance via ROS/p21/CHK1 axis.

Pair Name	Sanguinarium, Gefitinib
Phytochemical	Sanguinarium
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Targeting EGFR by elevating ROS and redox imbalance is a potential new strategy to develop a new EGFR inhibitor for TKI-resistant patients with a wide therapeutic window between EGFR(T790M) and EGFR(WT)

Pair Name	Shikonin, Gefitinib
Phytochemical	Shikonin
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Bcl-2-like protein 1		Expression
Result	Shikonin-induced cell apoptosis is closely associated with ROS elevation in the cells. These findings indicate that Shikonin can be an effective small molecule treating gefitinib-resistant NSCLC.