Pair Name	Lupeol, Paclitaxel
Phytochemical Name	Lupeol
Anticancer drug Name	Paclitaxel
Disease Info	[ICD-11: 2B66.0]	Oral squamous cell carcinoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Our findings elucidated mechanistic underpinning of hypoxia induced Laminin-5γ2 driven VM formation highlighting that Lupeol-Paclitaxel combination may serve as novel therapeutic intervention in perturbation of VM in human OSCC.

Pair Name	Ononin, Paclitaxel
Phytochemical Name	Ononin
Anticancer drug Name	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Our findings suggested that the therapeutic index of PTX-based chemotherapy could be improved by reducing toxicity with increasing antitumor capabilities when combined with ononin.

Pair Name	Polydatin, 2-Deoxy-d-glucose
Phytochemical Name	Polydatin
Anticancer drug Name	2-Deoxy-d-glucose
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Our study demonstrates that PD synergised with 2-DG to enhance its anti-cancer efficacy by inhibiting the ROS/PI3K/AKT/HIF-1α/HK2 signalling axis, providing a potential anti-cancer strategy.

Pair Name	Resveratrol, Cisplatin
Phytochemical Name	Resveratrol
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest

Pair Name	Alpha-Carotene, Paclitaxel
Phytochemical	Alpha-Carotene
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	We demonstrate that AC effectively inhibits LLC metastasis and suppresses lung metastasis in combination with taxol in LLC-bearing mice, suggesting that AC could be used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs.

Pair Name	Alpha-Hederin, Cisplatin
Phytochemical	Alpha-Hederin
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	α-Hederin enhances cisplatin-induced anti-tumour effects in GC both in vitro and in vivo by promoting the accumulation of ROS and decreasing MMP. Our data strongly suggested that α-Hederin is a promising candidate for intervention in gastric cancer.

Pair Name	Baicalein, Cisplatin
Phytochemical	Baicalein
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Treatment with baicalein improved the sensitivity of ovarian cancer cells to cisplatin and inhibited cell proliferation, metastasis and tumor growth

Pair Name	Berberine, Cisplatin
Phytochemical	Berberine
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Berberine and Cisplatin Exhibit Synergistic Anticancer Effects on Osteosarcoma MG-63 Cells by Inhibiting the MAPK Pathway

Pair Name	Beta-Ionone, Sorafenib
Phytochemical	Beta-Ionone
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	SF enhanced the suppressing effect of BI (1-50 μM) on the viability of SK-Hep-1 cells, but not on murine hepatic BNL CL.2 cells, indicating the selective cytotoxicity of this combination on tumor cells. The combination of SF and BI could be a potential therapeutic strategy against human hepatoma cells.

Pair Name	Biochanin A, Fluorouracil
Phytochemical	Biochanin A
Drug	Fluorouracil
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	The synergistic antitumor effect of Bio-A/ 5-FU combination can be, at least partly, attributed to Bio-A-mediated suppression of ER-α/Akt axis and the augmentation of 5-FU-mediated proapoptotic effects.

Pair Name	Bisdemethoxycucurmin, Icotinib
Phytochemical	Bisdemethoxycucurmin
Drug	Icotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Our data indicate that BMDC has the potential to improve the treatment of primary EGFR-TKI resistant NISCLC that cannot be controlled with single-target agent, such as icotinib.

Pair Name	Cordycepin, Cisplatin
Phytochemical	Cordycepin
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	This study provides comprehensive evidence that cordycepin inhibits osteosarcoma cell growth and invasion and induces osteosarcoma cell apoptosis by activating AMPK and inhibiting the AKT/mTOR signaling pathway and enhances the sensitivity of osteosarcoma cells to cisplatin, suggesting that cordycepin is a promising treatment for osteosarcoma.

Pair Name	Curcumenol, Cisplatin
Phytochemical	Curcumenol
Drug	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Curcumenol can enhance cisplatin to inhibit cancer cell proliferation, migration, and invasion and promote tumor cell apoptosis. The combination of drugs may promote the apoptosis of cervical cancer cells through the YWHAG pathway.

Pair Name	Curcumin, TNF-related apoptosis inducing ligand
Phytochemical	Curcumin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Combined treatment with curcumin and carboplatin inhibited tumor cell growth, migration, and invasion compared with either drug alone. The synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity

Pair Name	Emodin, Cisplatin
Phytochemical	Emodin
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	We found that emodin inhibited hepatocellular carcinoma (HCC) metastasis. Compared with either cisplatin or emodin alone, the combination of both showed a more significant synergistic effect. Emodin can enhance the sensitivity of HepG2 HCC cells to cisplatin by inhibiting epithelial-mesenchymal transition, and thus, play a role in preventing recurrence and metastasis in HCC.

Pair Name	Epigallocatechin gallate, TNF-related apoptosis inducing ligand
Phytochemical	Epigallocatechin gallate
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis

Pair Name	Erianin, Afatinib
Phytochemical	Erianin
Drug	Afatinib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	EBTP/Afa targets VEGF and EGFR signaling pathways in liver cancer cells and tumor vasculature, thereby inhibiting the proliferation, motion and angiogenesis of liver cancer cells. Overall, this study provides a new combined strategy for the clinical treatment of hepatocellular carcinoma.

Pair Name	Eugenol, Cisplatin
Phytochemical	Eugenol
Drug	Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	These results provide strong preclinical justification for combining cisplatin with eugenol as therapeutic approach for triple-negative breast cancers through targeting the resistant ALDH-positive cells and inhibiting the NF-κB pathway.

Pair Name	Fisetin, Sorafenib
Phytochemical	Fisetin
Drug	Sorafenib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Our findings demonstrate that fisetin potentiates the anti-invasive and anti-metastatic effects of sorafenib. Our data suggest that fisetin may be a worthy adjuvant chemotherapy for the management of melanoma.

Pair Name	Garcinol, Paclitaxel
Phytochemical	Garcinol
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Activity
Result	Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model

Pair Name	Ginsenoside Rg3, Endostar
Phytochemical	Ginsenoside Rg3
Drug	Endostar
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug, and it can inhibit angiogenesis and cell invasion, and enhance cell autophagy.

Pair Name	Harmine, Temozolomide
Phytochemical	Harmine
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Harmine Augments the Cytotoxic and Anti-invasive Potential of Temozolomide Against Glioblastoma Multiforme Cells

Pair Name	Liquiritigenin, Cisplatin
Phytochemical	Liquiritigenin
Drug	Cisplatin
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	The results suggested that LQ plays an intensive role on CDDP suppressing invasion and metastasis through regulating the PI3 K/AKT signal pathway and suppressing the protein expression of MMP-2/9.

Pair Name	Lupeol, Fluorouracil
Phytochemical	Lupeol
Drug	Fluorouracil
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	These data lay the foundation for the clinical validation of this combination therapy for TNBC patients.

Pair Name	Lycopene, Enzalutamide
Phytochemical	Lycopene
Drug	Enzalutamide
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.

Pair Name	Maslinic acid, Gemcitabine
Phytochemical	Maslinic acid
Drug	Gemcitabine
Disease Info	[ICD-11: 2C94]	Bladder cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	The results suggest that MA potentiates the antitumor effects of GEM in human GBC cell lines by suppressing the activation of NF-κB and its dowstream gene products, which are involved in survival signaling.

Pair Name	Methoxsalen, Temozolomide
Phytochemical	Methoxsalen
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	We showed a marked antitumor effect of 4MU on GBM cells alone and in combination with chemotherapy and proved, for the first time, the effect of 4MU on TMZ-resistant models, demonstrating that 4MU would be a potential therapeutic alternative for improving GBM therapy even on TMZ-refractory patients.

Pair Name	Patchouli alcohol, Cisplatin
Phytochemical	Patchouli alcohol
Drug	Cisplatin
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	The effects of patchouli alcohol and combination with cisplatin on proliferation, apoptosis and migration in B16F10 melanoma cells

Pair Name	Polydatin, Paclitaxel
Phytochemical	Polydatin
Drug	Paclitaxel
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Polydatin may enhance the chemosensitivity of osteosarcoma cells to paclitaxel.

Pair Name	Propyl gallate, Temozolomide
Phytochemical	Propyl gallate
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Activity
Result	Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κ B Pathway

Pair Name	Shikonin, Temozolomide
Phytochemical	Shikonin
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	From our results we conclude that dual treatment with SHK and TMZ may constitute a powerful new tool for GBM treatment by reducing therapy resistance and tumor recurrence.

Pair Name	Sulforaphane, Cisplatin
Phytochemical	Sulforaphane
Drug	Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	The results of the current study suggests that CIS when supplemented with SFN, inhibits metastasis and stemness potential of TNBC cells by down regulating SIRTs-mediated EMT cascade. Overall this study affirms that, this novel combination could be a promising strategy against SIRT-mediated TNBC metastasis and CIS-resistance.

Pair Name	Toosendanin, Regorafenib
Phytochemical	Toosendanin
Drug	Regorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	TSN and RGF combination (TRC) synergistically inhibited the proliferation and migration of MHCC-97L cells. The upregulation of WWOX (WW-domain containing oxidoreductase) played a vital role in the HCC cell growth treated with TRC

Pair Name	Tricetin, ERK inhibitor
Phytochemical	Tricetin
Drug	ERK inhibitor
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	SP-1 is an important target of tricetin for suppressing MMP-2-mediated cell motility in GBM cells, and a combination of tricetin and an ERK inhibitor may be a good strategy for preventing GBM invasion.

Pair Name	Zerumbone, Cisplatin
Phytochemical	Zerumbone
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	The current study indicates that the treatment of 4.62 μM of ZER combined with 1.93 μM of CIS in human liver cancer cells exerts synergistic effects on cell growth inhibition, apoptosis induction, angiogenesis, and invasion by modulating gene expression.

Pair Name	Noscapine, Docetaxel
Phytochemical	Noscapine
Drug	Docetaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Chemo-sensitizing effect of Nos followed by DTX regime provide a promising chemotherapeutic strategy and its significant role for the treatment of drug-resistant TNBC.

Pair Name	Noscapine, Docetaxel
Phytochemical	Noscapine
Drug	Docetaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	Chemo-sensitizing effect of Nos followed by DTX regime provide a promising chemotherapeutic strategy and its significant role for the treatment of drug-resistant TNBC.

Pair Name	Shikonin, Gemcitabine
Phytochemical	Shikonin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	These results indicate that shikonin reduced MCT4 expression and activation, resulting in inhibition of aerobic glycolysis in CAFs and overcoming CAF-induced gemcitabine resistance in PC. Shikonin is a promising chemosensitizing phytochemical agent when used in combination with gemcitabine for PC treatment. The results suggest that disrupting the metabolic coupling between cancer cells and stromal cells might provide an attractive strategy for improving gemcitabine efficacy.

Pair Name	Sulforaphane, Temozolomide
Phytochemical	Sulforaphane
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	72 kDa type IV collagenase		Expression
Result	The present study suggests that the clinical efficacy of TMZ-based chemotherapy in TMZ-resistant GBM may be improved by combination with SFN.