| Name | Signal transducer and activator of transcription 1 | ||
| UniProt ID | STAT1_HUMAN | ||
| Gene Name | STAT1 | ||
| Gene ID | 6772 | ||
| Synonyms |
STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
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| Sequence |
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 8.A.152.1.12 | ||
| KEGG ID | hsa6772 | ||
| TTD ID | T64205 | ||
| Pfam | PF00017; PF01017; PF02864; PF02865; PF12162; PF16519; PF21354 | ||
| Pair Name | Curcumin, Fluorouracil | |||
| Phytochemical Name | Curcumin | |||
| Anticancer drug Name | Fluorouracil | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Regulate Info | Down-regulation | Signal transducer and activator of transcription 1 | Phosphorylation | |
| Result | We conclude that curcumin promotes chemosensitivity of CRC cells to 5-FU by downregulating L1 expression. Our findings provide experimental evidence for the synergism between curcumin and 5-FU, which can be utilized in clinical applications for reducing the toxicity and adverse effects of 5-FU. | |||
| Pair Name | Gamma-Tocotrienol, SU11274 | |||
| Phytochemical | Gamma-Tocotrienol | |||
| Drug | SU11274 | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Regulate Info | Down-regulation | Signal transducer and activator of transcription 1 | Phosphorylation | |
| Result | Suggest that combined γ-tocotrienol and Met inhibitor treatment may provide benefit in treatment of breast cancers characterized by aberrant Met activity. | |||
| Pair Name | Ginsenoside Rh2, Anti-PD-L1 antibody | |||
| Phytochemical | Ginsenoside Rh2 | |||
| Drug | Anti-PD-L1 antibody | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Regulate Info | Up-regulation | Signal transducer and activator of transcription 1 | Phosphorylation | |
| Result | These findings demonstrated that Rh2 potentiated the anti-cancer effect of PD-L1 blockade via promoting the T cells infiltration and activation, which shed a new light on the combination strategy to enhance anti-PD-L1 immunotherapy by using natural product Rh2. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Low curcumin concentration enhances the anticancer effect of 5-fluorouracil against colorectal cancer. Phytomedicine. 2021 May;85:153547. doi: 10.1016/j.phymed.2021.153547. | Click |
| 2 | Combined γ-tocotrienol and Met inhibitor treatment suppresses mammary cancer cell proliferation, epithelial-to-mesenchymal transition and migration. Cell Prolif. 2013 Oct;46(5):538-53. doi: 10.1111/cpr.12059. | Click |
| 3 | Ginsenoside Rh2 augmented anti-PD-L1 immunotherapy by reinvigorating CD8+ T cells via increasing intratumoral CXCL10. Pharmacol Res. 2023 Dec;198:106988. doi: 10.1016/j.phrs.2023.106988. | Click |
